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Scar repair ointment and preparation method thereof

An ointment and scar technology, applied in the field of medical cosmetology, can solve problems such as skin damage, unknown ingredients, improper use by consumers, etc., and achieve the effects of promoting cell regeneration, good bioavailability, and preventing scars and acne marks.

Inactive Publication Date: 2019-04-16
南京紫源康医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although various products developed for scar removal have emerged in an endless stream in recent years, the ingredients are unknown, and consumers may use them improperly, which can easily cause skin damage. Skin dermis cells have a strong metabolism and smooth blood circulation. Damage caused by insufficient supply of nutrients, especially when the dermis of the skin is damaged, it is difficult for general nutrients to reach the dermis through the surface of the skin due to molecular weight and other problems for skin repair

Method used

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  • Scar repair ointment and preparation method thereof
  • Scar repair ointment and preparation method thereof
  • Scar repair ointment and preparation method thereof

Examples

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preparation example Construction

[0040] Two, the preparation of glycyrrhetinic acid monoglucuronide

[0041] (1) Place the glycyrrhizic acid of 1 mass part in the reactor, add the ionic liquid of 8 mass parts, the ionic liquid cation is 1-ethyl-3 methylimidazole [Emim] + , the ionic liquid anion is BF 4- The 1-ethyl-3-methylimidazolium tetrafluoroborate is stirred and dissolved to obtain a solution;

[0042] (2) Add 0.4 parts by mass of catalyst concentrated sulfuric acid into the solution for reaction, the reaction temperature is 30°C, and the reaction time is 3h;

[0043] (3) After the reaction finishes, adjust the pH value to 8, and separate the lower floor water from the system;

[0044] (4) Concentrate the water solution to obtain a solid, and add organic solvent methanol to crystallize at a mass ratio of 1:8 to obtain glycyrrhetinic acid monoglucuronide.

[0045] 3. Preparation of scar repair ointment

Embodiment 1

[0046] Embodiment 1: The formula of scar repair ointment is as follows: the total amount is 100 parts by weight, A phase components: 80.77 parts of distilled water, 0.5 part of AVC, 0.02 part of hyaluronic acid, 0.1 part of allantoin, 0.15 part of p-hydroxybenzene Methyl formate; Phase B components: 5 parts olive oil, 2 parts isopropyl palmitate, 2 parts isooctyl palmitate, 1 part dimethicone, 0.5 parts olive oil emulsifying wax, 1.5 parts cetearyl Alcohol, 1 part of monoglyceride stearate, 1 part of jojoba oil, 1 part of squalane, 0.5 part of Pingpinga 25, 0.2 part of oil-soluble VE, 0.2 part of Span 60, 0.05 part of propylparaben; Phase C components: 0.1 part of glycyrrhetinic acid monoglucuronide, 0.2 parts of asiaticoside, 0.2 parts of phenoxyethanol; components of phase D: 0.01 parts of shikonin, 1 part of propylene glycol, 0.5 parts of lavender essential oil, 0.5 parts Evening primrose essential oil.

[0047] Preparation of Phase A: Weigh the distilled water, AVC, hyalu...

Embodiment 2

[0051] Embodiment 2: The formula of scar repair ointment is as follows: Based on the total amount of 100 parts by weight, A phase components: 77 parts of distilled water, 0.7 part of AVC, 0.03 part of hyaluronic acid, 0.2 part of allantoin, 0.1 part of p-hydroxybenzene Methyl formate; Phase B components: 6 parts olive oil, 3 parts isopropyl palmitate, 1 part isooctyl palmitate, 1.5 parts dimethicone, 0.8 parts olive oil emulsifying wax, 1 part cetearyl Alcohol, 0.5 part of monoglyceride stearate, 1 part of jojoba oil, 1 part of squalane, 1 part of Pingpinga 25, 0.4 part of oil-soluble VE, 0.4 part of Span 60, 0.06 part of propyl paraben; Phase C components: 0.15 parts of glycyrrhetinic acid monoglucuronide, 0.3 parts of asiaticoside, 0.3 parts of phenoxyethanol; components of phase D: 0.01 parts of shikonin, 1.5 parts of propylene glycol, 1 part of lavender essential oil, 1 part Evening primrose essential oil.

[0052] Preparation of Phase A: Weigh the formula quantities of d...

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Abstract

The invention discloses a scar repair ointment and a preparation method thereof. The scar repair ointment comprises the following components: lavender essential oil, evening primrose essential oil, shikonin, asiaticoside and glycyrrhetic acid monoglucuronide. The scar repair ointment is prepared by the following method: (1) adding glycyrrhizic acid to the ionic liquid, stirring to obtain a solution, adding a catalyst, adjusting the pH value, separating the lower layer of water, concentrating and adding an organic solvent for crystallization; (2) heating the phase A, stirring evenly and keepingthe temperature constant; (3) heating the phase B, stirring evenly and adding the phase B to the phase A; (4) after uniform emulsification, cooling, adding the phase C and the phase D containing theproduct in the step (1) and stirring evenly. The ointment has the advantages of adopting a natural plant efficacy formula, being antibacterial and anti-inflammatory, promoting blood circulation, softening hardness and dispersing mass and beautifying the skin. The ointment is used for repairing scars formed after injury and operations, can effectively banish various scars on the surface of the skin, can make the skin smooth and delicate and has a good cosmetic effect.

Description

technical field [0001] The invention belongs to the field of medical cosmetology, and in particular relates to the preparation of a scar repair ointment, in particular to a scar repair ointment and a preparation method thereof. Background technique [0002] Scar is formed after the skin tissue of the human body is subjected to various external traumas, and the skin fibrous connective tissue hyperplasia fills, connects, supports, and protects the surrounding normal tissues at the wound healing site. The main cause of scars is the irregular growth and thickening of collagen fibers in the deep part of the scar, which is irregularly arranged, or wavy, or entangled into ropes. Moreover, the blood vessels and nerves inside the scar are disordered, lack of stable blood supply and activity function, and often show redness, swelling, itching and numbness. [0003] Scars not only destroy the beauty of the body surface, but may also affect the function of related tissues or organs, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/06A61P9/14A61P17/02A61P29/00A61P31/02A61K31/122A61K31/704A61K31/7024
CPCA61K9/0014A61K9/06A61K31/122A61K31/7024A61K31/704A61K36/185A61K36/53A61K47/44A61P9/14A61P17/02A61P29/00A61P31/02A61K2300/00
Inventor 刘亿宁魏元刚钟慧易铭杨永安
Owner 南京紫源康医药科技有限公司
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