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Hydrophobic nanogel and preparation method thereof

A hydrophobic and gel technology, applied in the field of nanomaterials, can solve the problems of less hydrophobic nanogel preparation and mechanism research, and achieve the effects of high safety, increased adsorption capacity, and uniform distribution.

Active Publication Date: 2019-03-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In recent years, the research direction of nanogels has mainly focused on hydrophilicity and amphiphilicity, and there are few studies on the preparation and mechanism of hydrophobic nanogels.

Method used

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  • Hydrophobic nanogel and preparation method thereof
  • Hydrophobic nanogel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Based on the total amount of all raw materials as 100%, a mixed solution containing 0.59% glycidyl methacrylate, 0.41% ethylene glycol dimethacrylate, 0.5% sodium lauryl sulfate and 98.41% deionized water Mix well in a glass bottle by ultrasonic mixing to form an oil-in-water emulsion. Place it in a water bath temperature of 70°C, and simultaneously add 3% of the total mass of both glycidyl methacrylate and ethylene glycol dimethacrylate. Ammonium persulfate and 6% N,N,N',N' -Tetramethylethylenediamine catalyst, continue to stand for 8 min at 70℃, and quickly cool to room temperature after the reaction is completed, to obtain the crude polyglycidyl methacrylate nanogel, and the obtained polyglycidyl methacrylate The crude ester nanogel was tested with the Malvern ZS90 particle size analyzer to test the particle size of the nanogel. The obtained nanogel has a particle size of 10~190 nm, an average particle size of about 41 nm, and a Zeta potential of about -40 mV. The in...

Embodiment 2

[0024] Based on the total amount of all raw materials as 100%, a mixed solution containing 2.8% glycidyl methacrylate, 0.2% ethylene glycol dimethacrylate, 2% sodium lauryl sulfate and 94.73% deionized water Mix well by ultrasonic in a glass bottle to form an oil-in-water emulsion. Place it at a water bath temperature of 50°C, and simultaneously add 3% persulfuric acid with the total mass of glycidyl methacrylate and ethylene glycol dimethacrylate. Ammonium and 6% N,N,N',N' -Tetramethylethylenediamine catalyst, continue to stand for reaction at 50°C for 10 min, and quickly cool to room temperature after the reaction is completed, to obtain polyglycidyl methacrylate nanogel. The prepared polyglycidyl methacrylate nanogel was tested for the particle size of the nanogel with a Malvern ZS90 particle size analyzer. The obtained nanogel has a particle size of 40-250 nm, an average particle size of about 90 nm, a Zeta potential of -49 mV, and a dispersion index of 0.17.

Embodiment 3

[0026] Based on the total amount of all raw materials as 100%, a mixed solution containing 4.93% glycidyl methacrylate, 0.07% ethylene glycol dimethacrylate, 2.5% sodium lauryl sulfate and 92.41% deionized water Mix well by ultrasonic in a glass bottle to form an oil-in-water emulsion. Place it at a temperature of 70°C in a water bath, and simultaneously add 0.6% persulfuric acid with the total mass of glycidyl methacrylate and ethylene glycol dimethacrylate. Ammonium and 1.2% N,N,N',N' -Tetramethylethylenediamine catalyst, continue to stand for reaction at 70°C for 8 min, and quickly cool to room temperature after the reaction is completed to obtain polyglycidyl methacrylate nanogel. The prepared polyglycidyl methacrylate nanogel was tested for the particle size of the nanogel with a Malvern ZS90 particle size analyzer. The obtained nanogel has a particle size of 30-220 nm, an average particle size of about 70 nm, a Zeta potential of about -40 mV, and a dispersion index of ab...

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Abstract

The invention discloses a hydrophobic nanogel and a preparation method thereof. The hydrophobic nanogel adopts polyglycidyl methacrylate as a framework, has a particle size of 10-250 nm, a Zeta potential of -40 to -50 mV and a dispersion index of 0.1-0.2, and has a structure containing a hydrophobic glyceride group and a highly-active epoxy group structure, represented by formula (I), and each ofm and n in the formula (I) is an integer greater than zero. The novel hydrophobic nanogel has the dual characteristics of a hydrogel and a nanomaterial, has the advantages of small size, stable dispersion, uniform distribution and large specific surface area, and can be combined with other biochemical separation media to increase internal adsorption sites in the media in order to increase the adsorption amount; and the polyglycidyl methacrylate and other polymer materials with good biocompatibility are used, so the nanogel is highly safe.

Description

Technical field [0001] The invention relates to the field of nanomaterials, in particular to a hydrophobic nanogel and a preparation method thereof. Background technique [0002] Nanogels refer to gel particles with a three-dimensional network structure and a particle size less than 1000 nm formed by cross-linking polymer chains through chemical or physical interactions. There is an affinity between water and the gel network. Water can exist in the nanogel network in the form of bound water, bound water and free water, and lose fluidity. Therefore, the nanogel is swellable in water but insoluble Features and can maintain a certain stable state. [0003] Nanogels have the dual characteristics of hydrogels and nanomaterials. They are small in size and large in specific surface area. Some nanogels can quickly respond to changes in the surrounding environment, such as pH, temperature, and light. The stimulus response phenomenon with biologically active substances can detect the conce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/32C08F222/14C08J3/075
CPCC08F220/32C08J3/075C08J2333/14C08F220/325C08F222/102
Inventor 张颂红杨婷婷黄杰贠军贤
Owner ZHEJIANG UNIV OF TECH
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