Aspirin tablet and preparation method thereof

A technology of aspirin tablets and aspirin, which is applied in the field of aspirin tablets and its preparation, can solve the problems of general compressibility of aspirin raw materials, unfavorable industrial production, and high proportion of components, and achieve industrial production, high dissolution rate, and stable quality Good results

Inactive Publication Date: 2019-03-29
HUAZHONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, the compressibility of aspirin raw materials is average, and the proportion of components in aspirin tablets is high, and the compatibility of conventional excipients has problems such as poor compressibility and low hardness, which is not conducive to industrial production

Method used

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  • Aspirin tablet and preparation method thereof
  • Aspirin tablet and preparation method thereof
  • Aspirin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment provides a kind of aspirin tablet, totaling 3 million tablets, which includes the following raw materials in parts by weight: 300 kg of aspirin, 46 kg of microcrystalline cellulose ZW102 type, 18 kg of pregelatinized starch, and 6 kg of talcum powder.

[0036] The preparation method of the aspirin tablet of the present embodiment, comprises the steps:

[0037] S1, weigh each raw material according to the raw material composition of the aspirin tablet in this embodiment.

[0038] S2, use a fast granulator to pass the aspirin raw material through a 1.5mm mesh stainless steel screen at a speed of 600r / min, and granulate to obtain whole granules of aspirin, so as to improve the fluidity, compressibility and formability of the material. The yield of aspirin in this step is 99.6%, material balance: 99.5-100.0%.

[0039] S3, using a GM-1500 three-dimensional mixer to mix the whole aspirin with microcrystalline cellulose, pregelatinized starch, and talcum powde...

Embodiment 2

[0043] The present embodiment provides an aspirin tablet, 600,000 tablets in total, including the following raw materials in parts by weight: 180 kg of aspirin, 30 kg of microcrystalline cellulose ZW101 type, 18 kg of pregelatinized starch, and 6 kg of talcum powder.

[0044] The preparation method of the aspirin tablet of the present embodiment, comprises the steps:

[0045] S1, weigh each raw material according to the raw material composition of the aspirin tablet in this embodiment.

[0046] S2, the aspirin raw material is passed through a 1.5mm mesh stainless steel screen by a fast granulation machine at a speed of 600r / min, and the granules are sized to obtain whole granules of aspirin. The yield of aspirin in this step is 99.8%, material balance: 99.5-100.0%.

[0047] S3, using a GM-1500 three-dimensional mixer to mix the whole aspirin with microcrystalline cellulose, pregelatinized starch, and talcum powder at a speed of 6 r / min and a mixing time of 15 min. The yield ...

Embodiment 3

[0050] This embodiment provides a kind of aspirin tablet, totaling 300,000 tablets, which includes the following raw materials in parts by weight: 150 kg of aspirin, 24 kg of microcrystalline cellulose ZW102 type, 6 kg of pregelatinized starch, and 4.5 kg of talcum powder.

[0051] The preparation method of the aspirin tablet of the present embodiment, comprises the steps:

[0052] S1, weigh each raw material according to the raw material composition of the aspirin tablet in this embodiment.

[0053] S2, the aspirin raw material is passed through a 1.5mm mesh stainless steel screen by a fast granulation machine at a speed of 600r / min, and the granules are sized to obtain whole granules of aspirin. The yield of aspirin in this step is 99.8%, material balance: 99.5-100.0%.

[0054]S3, using a GM-1500 three-dimensional mixer to mix the whole aspirin with microcrystalline cellulose, pregelatinized starch, and talcum powder at a speed of 6 r / min and a mixing time of 15 min. The y...

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Abstract

The invention relates to an aspirin tablet and a preparation method thereof. The aspirin tablet is prepared by directly tabletting the following raw materials in parts by weight: 130-350 parts of aspirin, 20-50 parts of microcrystalline cellulose, 3-20 parts of pre-gelatinized starch and 0-10 parts of talcum powder. The aspirin tablet disclosed by the invention is compounded from raw materials with specific types and specific parts by weight, and the aspirin is not easy to degrade so as to generate salicylic acid. The quality stability is good, the dissolution rate is high, and the method is convenient to directly tabletting powder, is beneficial to industrial production, and can reduce production cost.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an aspirin tablet and a preparation method thereof. Background technique [0002] Aspirin (acetylsalicylic acid) is one of the antipyretic and analgesic drugs widely used clinically. It has a history of 100 years and is still the most widely used antipyretic, analgesic and anti-inflammatory drug in the world. The analgesic and anti-inflammatory effects of aspirin are mainly achieved by inhibiting the synthesis of prostaglandins and other substances that can sensitize pain to mechanical or chemical stimuli (such as bradykinin, histamine). In addition, aspirin also has an antithrombotic effect in the body, can inhibit the release reaction of platelets, inhibit the aggregation of platelets, and is also clinically used to prevent cardiovascular and cerebrovascular diseases. [0003] The absorption and utilization efficiency of aspirin in the body is directly rela...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/36A61K47/02A61K31/616A61P29/00
CPCA61K9/2009A61K9/2054A61K9/2059A61K9/2095A61K31/616A61P29/00
Inventor 汤伟黄艳玲余丰姚庆红申海波
Owner HUAZHONG PHARMA
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