Nanocomposite using tetrastyryl indole derivative as photosensitizer, preparation method and application to tumor therapy

Abstract

The invention provides synthesis of a tetrastyryl indole compound and a novel application to tumor therapy, and particularly relates to design and synthesis of the tetrastyryl indole compound, preparation of a nano-support, synthesis of a nano composite drug and an application to preparation of an anti-tumor photosensitive drug based on photodynamic and photothermal collaborative treatment. Tetrastyryl is taken as the center, methoxy and indole groups are introduced to serve as an electron donor and a receptor respectively, the energy gap value of molecules is reduced, molecules with higher singlet oxygen quantum yield are obtained and linked to surfaces of polydopamine nanoparticles under the action of hydrogen bonds and pi-pi bonds, and a nanocomposite with mitochondrion targeted imagingas well as photodynamic and photothermal dual activity is constructed. The photodynamic and photothermal collaborative effect of the nanocomposite under the action of illumination is proved on the cell and animal levels, and photoinduced tumor ablation is realized.

Description

technical field [0001] The invention relates to the design and synthesis of a tetraphenylethylene indole photosensitizer and the introduction of a polydopamine carrier to construct a nanocomposite material for photodynamic and photothermal synergistic anti-tumor treatment at the cell and animal levels. Background technique [0002] Photodynamic therapy is a method based on photosensitizer molecules being activated by a light source of a specific wavelength, and energy transfer occurs to generate active oxygen molecules. Singlet oxygen molecules are a type of active oxygen molecules that are often used. Overexpression of singlet oxygen will cause Causes damage and destruction of cellular macromolecules (such as proteins, liposomes, and DNA), eventually causing apoptosis and necrosis. Traditional photosensitizers include porphyrin derivatives, anthraquinones, thiaphenazines, anthocyanins, and curcumin. Good photodynamic therapy effects are closely related to the performance of...

AI Technical Summary

Problems solved by technology

However, the nano-scale photosensitizer prepared by this method is not uniform in shape and has poor stability in water environment, which limits its application in vivo

Moreover, so far there are few reports on the use of aggregation-inducing photosensitizers to target organelles to enhance the effect of photodynamic therapy, and there are still some challenges.

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