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Medicine spray for treating rhinitis and preparation method thereof

A spray and drug technology, applied in the field of drug preparation, can solve the problems of drug allergy, drug effect damage, and drug effect, and achieve the effect of improving nasal immune barrier function, ensuring curative effect, and reasonable treatment

Inactive Publication Date: 2019-03-01
何凤姣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many medicines for treating rhinitis, and the most commonly used ones are mainly taken orally. The main disadvantage of taking medicines internally is that they must be decomposed in the digestive tract and sent to the liver for processing, which will inevitably produce the so-called first-pass effect, and the efficacy of the medicine has been destroyed. , and then sent to the nasal mucosa through the systemic circulation, so the amount of medicine that can reach the nose is already very small, and the drug effect that can be produced is even less, so it has the disadvantages of slow onset of action and small drug effect, and the drug is prone to allergic problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A medicinal spray for treating rhinitis, comprising the following raw materials in parts by weight: 20 parts of qingyangshen aglycone, 15 parts of sanzuanfeng, 11 parts of policinic acid, 8 parts of cycloartanol, and homopsyllogenin 1 part, 2 parts of clindamycin, 3 parts of chromogenone, 2 parts of glycyrrhizin, 3 parts of polygalic acid, 1 part of synergist, 1 part of chlorobutanol, 3 parts of sodium benzoate, 800 parts of distilled water , 2 parts of gluconate chloride, 1 part of acetaminophen, 1 part of benproperine, 1 part of Wenxingcao, 2 parts of plant volatile oil.

[0022] The synergist is a mixture of watermelon frost spray and nitrofurazone powder, the mass ratio of which is 1:2, and the plant volatile oil is magnolia volatile oil.

[0023] A preparation method of the drug spray for the treatment of rhinitis, comprising the following steps:

[0024] S1: Weighing Qingyangshen aglycone, Sanzuanfeng, Wenxingcao, Polleninic acid, Cycloartanol and Homopsyllogenin...

Embodiment 2

[0032] A medicinal spray for treating rhinitis, comprising the following raw materials in parts by weight: 23 parts of qingyangshen aglycone, 19 parts of sanzuanfeng, 13 parts of policinic acid, 9 parts of cycloartanol, and homopsyllogenin 2 parts, 3 parts of clindamycin, 4 parts of chromogenone, 4 parts of licorice root, 4 parts of polygalic acid, 2 parts of synergist, 2 parts of chlorobutanol, 4 parts of sodium benzoate, 85 parts of distilled water , 4 parts of gluconate chloride, 1.5 parts of acetaminophen, 1.5 parts of benproperine, 2 parts of Wenxingcao, and 4 parts of plant volatile oil.

[0033] The synergist is a mixture of watermelon frost spray and nitrofurazone powder, the mass ratio of which is 1:2, and the plant volatile oil is magnolia volatile oil.

[0034] A preparation method of the drug spray for the treatment of rhinitis, comprising the following steps:

[0035] S1: Weighing Qingyangshen aglycone, Sanzuanfeng, Wenxingcao, Polleninic acid, Cycloartanol and H...

Embodiment 3

[0043] A medicinal spray for treating rhinitis, comprising the following raw materials in parts by weight: 26 parts of qingyangshen aglycone, 24 parts of sanzuanfeng, 15 parts of policinic acid, 10 parts of cycloartanol, and homopsyllogenin 3 parts, 5 parts of clindamycin, 6 parts of chromogenone, 5 parts of liquiritigenin, 5 parts of polygalic acid, 3 parts of synergist, 3 parts of chlorobutanol, 5 parts of sodium benzoate, 90 parts of distilled water , 6 parts of gluconate chloride, 2 parts of acetaminophen, 2 parts of benproperine, 3 parts of Wenxingcao, 5 parts of plant volatile oil.

[0044] The synergist is a mixture of watermelon frost spray and nitrofurazone powder, the mass ratio of which is 1:2, and the plant volatile oil is magnolia volatile oil.

[0045] A preparation method of the drug spray for the treatment of rhinitis, comprising the following steps:

[0046] S1: Weighing Qingyangshen aglycone, Sanzuanfeng, Wenxingcao, Polleninic acid, Cycloartanol and Homopsy...

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PUM

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Abstract

The invention discloses a medicine spray for treating rhinitis and belongs to the technical field of medicine preparation. The medicine spray is prepared from the following raw materials in parts by weight: 20 to 32 parts of cynanchagenin, 15 to 33 parts of Japanese spicebush bark, 11 to 19 parts of tormentic acid, 8 to 12 parts of cycloartanol, 1 to 5 parts of homoplantaginin, 2 to 8 parts of clindamycin, 3 to 9 parts of capillarisin, 2 to 8 parts of glycyrrhizin, 3 to 7 parts of polygalic acid, 1 to 5 parts of synergists, 1 to 5 parts of acetone chloroform, 3 to 7 parts of sodium benzoate, 80 to 100 parts of distilled water, 2 to 10 parts of chlorine gluconate, 1 to 3 parts of paracetamol, 1 to 3 parts of benproperine, 1 to 5 parts of herb eriocaulon buergerianum and 2 to 8 parts of plant essential oil. The medicine spray has the advantages that the curative effect is obvious; no toxic or side effect exists; both symptoms and root causes can be treated; the treatment method is more reasonable; the exact curative effect can be achieved on relieving the disease and pain of rhinitis.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a medicine spray for treating rhinitis and a preparation method thereof. Background technique [0002] Rhinitis is an acute or chronic inflammation caused by damage to the nasal mucosa or submucosal tissue due to viral infection, bacterial infection, or irritants. Rhinitis causes excess mucus production, often causing symptoms such as runny nose and nasal congestion. Unlike hay fever, the symptoms of perennial rhinitis fluctuate throughout the year (often unpredictable), and non-nasal symptoms (such as conjunctivitis) are rare, but chronic nasal congestion is often obvious, and can develop into Eustachian tube obstruction , resulting in hearing loss. [0003] At present, there are many medicines for treating rhinitis, and the most commonly used ones are mainly taken orally. The main disadvantage of taking medicines internally is that they must be decomposed in the ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61K9/12A61P11/02A61P29/00A61K31/045A61K31/192A61K31/167A61K31/4453A61K31/345
CPCA61K36/575A61K9/0043A61K9/12A61K31/045A61K31/167A61K31/192A61K31/345A61K31/4453A61K36/42A61K36/54A61K36/88A61P11/02A61P29/00A61K2300/00
Inventor 何凤姣
Owner 何凤姣
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