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Polyamino acid based mussel bionic tissue adhesive and preparation method thereof

A polyamino acid and mussel-based technology, which is applied in the direction of adhesives, non-polymer adhesive additives, adhesive additives, etc., can solve problems such as increasing patient pain, adverse reactions of tissues and organs, and immune system diseases, and achieve process parameters Ease of control, excellent biocompatibility, and simple preparation methods

Active Publication Date: 2019-02-19
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the most clinically used tissue adhesives include fibrin glue, cyanoacrylate and gelatin-aldehyde adhesives, etc., but they all have shortcomings, such as the insufficient bonding strength of fibrin glue under physiological conditions , although cyanoacrylate and gelatin-aldehyde adhesives have high bond strength, they are poor in biocompatibility and prone to inflammatory reactions
In addition, these traditional tissue adhesives lack inherent antibacterial properties, and infection during the use of tissue adhesives is a frequent problem. Infections can delay wound healing, and even cause immune system diseases, increasing the suffering of patients. Traditional tissue adhesives Often additional antimicrobial drugs, such as antibiotics, are required, which can cause adverse reactions in normal tissues and organs

Method used

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  • Polyamino acid based mussel bionic tissue adhesive and preparation method thereof
  • Polyamino acid based mussel bionic tissue adhesive and preparation method thereof
  • Polyamino acid based mussel bionic tissue adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A. Weigh 10g of L-aspartic acid and 1g of 85% phosphoric acid according to the mass ratio of 10:1, pour them into a weighing bottle, add deionized water until the liquid surface completely covers the solid. Stir at 400r / min for 10 minutes. Then place it open, and heat at 200°C for 8 hours to undergo solid phase polymerization, and react to obtain a polysuccinimide prepolymer.

[0043] B. Dissolve the crude polysuccinimide above in an appropriate amount of N,N-dimethylformamide solution, and stir at 400 r / min for 2 hours while heating in a water bath at 40°C. Phosphoric acid and unreacted L-aspartic acid were removed by suction filtration. Add deionized water to precipitate, suction filter and wash with deionized water three times, and dry at 80°C to obtain a purified polysuccinimide prepolymer.

[0044] C. Weigh 5g (50mmol) polysuccinimide prepolymer, 9.5g (50mmol) dopamine hydrochloride, 6.5g (77mmol) sodium bicarbonate, dissolve in 100ml deionized water, react in a ...

Embodiment 2

[0047] A. Weigh 10g of L-aspartic acid and 1g of 85% phosphoric acid according to the mass ratio of 10:1, pour them into a weighing bottle, add deionized water until the liquid surface completely covers the solid. Stir at 400r / min for 10 minutes. Then it was left open and heated at 210°C for 10 hours to undergo solid phase polymerization. During this period, stir evenly after the deionized water is volatilized, and then crush the solid particles into powder and stir every hour. The reaction yields crude polysuccinimide.

[0048] B. Dissolve the crude polysuccinimide above in an appropriate amount of N,N-dimethylformamide solution, and stir at 400 r / min for 3 hours while heating in a water bath at 40°C. Phosphoric acid and unreacted L-aspartic acid were removed by suction filtration. Add deionized water to precipitate, suction filter and wash with deionized water three times, and dry at 80°C to obtain purified polysuccinimide.

[0049] C. Weigh 5g (50mmol) polysuccinimide, ...

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Abstract

The invention provides a polyamino acid based mussel bionic tissue adhesive and a preparation method thereof. The polyamino acid based mussel bionic tissue adhesive is prepared by the following stepsthat a polyamino acid based grafted dopamine prepolymer is synthesized; a compound cross-linking agent is prepared; the prepolymer water solution with the concentration of 30-50% by weight and the compound cross-linking agent water solution are mixed evenly according to the ratio of 1-2 to 1, and the polyamino acid based mussel bionic tissue adhesive is prepared through cross linked gelatinization. For solving the existing problems of tissue adhesives, the preparation method of the polyamino acid based mussel bionic tissue adhesive is prepared. The tissue adhesive has the high bonding strengthunder physiological conditions, creatively utilizes MgO nano particles to form a crosslinking system and is endowed with intrinsic antibacterial property and biological activity.

Description

technical field [0001] The invention relates to a bionic tissue adhesive and a preparation method thereof, in particular to a polyamino acid-based mussel bionic tissue adhesive and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] Every year, millions of patients around the world need to suture their wounds due to trauma or surgery. At present, the widely used method in clinical practice is to suture the wound with sutures or rivets. Defects such as inconvenient operation, susceptibility to infection, and scars left after healing. Tissue adhesive is a kind of medical material that can cross-link at the wound site to make fast adhesion between tissues or between tissues and non-tissues. An ideal tissue adhesive should have sufficient bond strength and durability, good biocompatibility and biodegradability. At present, the most clinically used tissue adhesives include fibrin glue, cyanoacrylate and gelatin-aldehyde ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J179/08C09J11/04
CPCC08K2003/222C08K2201/011C09J11/04C09J179/08C08K3/22C08K3/24
Inventor 鲁玺丽许国栋邹芳孙志洁
Owner HARBIN ENG UNIV
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