Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ocular surface drip anti-angiogenesis eye-drops preparation and preparation method thereof

A technology for new blood vessels and ophthalmic preparations, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve problems such as poor dispersion and unfavorable drug bioavailability, and achieve the goal of avoiding side effects Effect

Inactive Publication Date: 2019-01-08
WENZHOU MEDICAL UNIV
View PDF5 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a class of hydrophobic small molecule drugs, the dispersion in water is poor, which is not conducive to the bioavailability of drugs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ocular surface drip anti-angiogenesis eye-drops preparation and preparation method thereof
  • Ocular surface drip anti-angiogenesis eye-drops preparation and preparation method thereof
  • Ocular surface drip anti-angiogenesis eye-drops preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The present invention is described in detail below in conjunction with accompanying drawing and embodiment

[0015] The ocular surface instillation anti-neovascular ophthalmic preparation provided by the present invention is formed by a well-compatible amphiphilic self-assembled polymer loaded with a hydrophobic small molecule drug, and the preparation can be formed by self-assembly above the critical micelle concentration shell-core structure. The amphiphilic self-assembled polymer is PEG-PCL, PEG-PLGA or DSPE-PEG, and the hydrophobic small molecule drug is axitinib.

[0016] refer to figure 1 , figure 2 As shown, the present invention also provides a preparation method for the above ocular surface instillation of anti-neovascular ophthalmic preparations, comprising the following steps: a, using acetone or dichloromethane or methanol to dissolve the polymer and the small molecule tyrosine kinase respectively Inhibitor (Axitinib); b. The polymer-drug composite film ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an ocular surface drip anti-angiogenesis eye-drops preparation formed by loading hydrophobic small molecule drugs on amphiphilic self-assembled polymers with excellent compatibility. The preparation can be self-assembled to form a core-shell structure at a critical micelle concentration or higher. The invention further provides a preparation method of the ocular surface drip anti-angiogenesis eye-drops preparation. Preparation of eye drops is completed by loading the hydrophobic small molecule drugs on the amphiphilic self-assembled polymers with excellent compatibility, the amphiphilic polymers (such as PEG (Polyethylene Glycol)-PCL (Polycaprolactone), PEG-PLGA and common DSPE-PEG) can complete loading of anti-angiogenesis drugs in the process of being assembled into nanoparticles, a signal path of angiogenesis is inhibited, a small-molecule tyrosine kinase inhibitor applicable to tumor therapy is combined with an increasingly mature nano drug-loading technology, and a novel candidate drug used for ocular surface angiogenesis resistance is prepared. The novel drug is economic and safe, and provides an excellent solution for avoiding side effects of hormonaldrugs.

Description

technical field [0001] The invention relates to an ocular surface instillation anti-new blood vessel ophthalmic preparation. The present invention also relates to a preparation method of the above-mentioned ocular surface instillation anti-neovascular ophthalmic preparation. Background technique [0002] Eye diseases, including ocular surface and fundus-related diseases, are related to the quality of human life. New blood vessels are the manifestation of the occurrence and development of eye diseases. The increase of new blood vessels will increase the risk of eye blindness. Among the existing treatments, hormonal drugs, such as diclofenac and dexamethasone, are routinely used. While treating neovascular eye diseases, they may cause side effects of secondary cataract and acute glaucoma caused by drugs. Therefore, in order to safely improve the drug treatment effect of ocular vascular-related diseases, it is urgent to develop new therapeutic drugs or increase alternative dru...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/107A61K9/51A61K31/4439A61K47/34A61K47/24A61P27/02
CPCA61P27/02A61K9/0048A61K9/1075A61K9/5146A61K31/4439
Inventor 师帅黄锦海彭芳丽陈浩李星熠
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com