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Rare earth phosphate/bioactive polymer three-dimensional porous composite material, preparation method and application thereof

A rare earth phosphate, polymer material technology, applied in the fields of inorganic non-metallic materials, biomedical materials, organic bioactive polymer materials, can solve problems such as unclear effect, achieve favorable cell adhesion, high porosity, cycle time short effect

Active Publication Date: 2019-01-04
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rare-earth metal-based scaffolds such as La have so far been rarely used in biomaterials, and their role in osteogenesis remains unclear

Method used

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  • Rare earth phosphate/bioactive polymer three-dimensional porous composite material, preparation method and application thereof
  • Rare earth phosphate/bioactive polymer three-dimensional porous composite material, preparation method and application thereof
  • Rare earth phosphate/bioactive polymer three-dimensional porous composite material, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] (1) 2.9877g La(NO 3 ) 3 ·6H 2 O and 0.9112g (NH 4 ) 2 HPO 4 were dissolved in 100mL deionized water to prepare La(NO 3 ) 3 aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution.

[0060] (2) to (NH 4 ) 2 HPO 4 Add NH to the aqueous solution 3 ·H 2 O adjust the pH to 11.5, then (NH 4 ) 2 HPO 4 The aqueous solution was placed in a 20°C oil bath for mechanical stirring while adding La(NO 3 ) 3 The aqueous solution, after the dropwise addition, was stirred at 90°C for 1 hour, then stirred at 20°C for 24 hours, filtered and washed to obtain a neutral precipitate, dried at 50°C for 12 hours, and calcined at 500°C for 6 hours to obtain lanthanum phosphate (LaPO 4 ) powder with a particle size of 50nm to 5μm.

[0061] (3) Take 100 mL of acetic acid solution with a volume fraction of 1%, add 4.0 g of chitosan, and stir to completely dissolve the chitosan until clear and transparent.

[0062] (4) Add 4.0 g of lanthanum phosphate powder into the chitosan solut...

Embodiment 2

[0072] (1) 2.9877g La(NO 3 ) 3 ·6H 2O and 0.9112g (NH 4 ) 2 HPO 4 were dissolved in 100mL deionized water to prepare La(NO 3 ) 3 aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution.

[0073] (2) to (NH 4 ) 2 HPO 4 Add NH to the aqueous solution 3 ·H 2 O to adjust the pH to 11, the (NH 4 ) 2 HPO 4 The aqueous solution was placed in a 20°C oil bath for mechanical stirring while adding La(NO 3 ) 3 The aqueous solution, after the dropwise addition, was stirred at 70°C for 1 hour, then stirred at 20°C for 24 hours, filtered and washed to obtain a neutral precipitate, dried at 90°C for 5 hours, and calcined at 1000°C for 6 hours to obtain lanthanum phosphate (LaPO 4 ) powder with a particle size of 50nm to 5μm.

[0074] (3) Take 100 mL of acetic acid solution with a volume fraction of 4%, add 2.0 g of collagen, and stir to completely dissolve the collagen until clear and transparent.

[0075] (4) Add 4.0 g of lanthanum phosphate powder into the collagen soluti...

Embodiment 3

[0082] (1) 2.9961g Ce(NO 3 ) 3 ·6H 2 O and 0.9112g (NH 4 ) 2 HPO 4 were dissolved in 100mL deionized water to prepare Ce(NO 3 ) 3 aqueous solution and (NH 4 ) 2 HPO 4 aqueous solution.

[0083] (2) to (NH 4 ) 2 HPO 4 Add NH to the aqueous solution 3 ·H 2 O to adjust the pH to 11, the (NH 4 ) 2 HPO 4 The aqueous solution was placed in an oil bath at 40°C for mechanical stirring while adding Ce(NO 3 ) 3 The aqueous solution, after the dropwise addition, was stirred at 90°C for 2 hours, then stirred at 40°C for 24 hours, filtered and washed to obtain a neutral precipitate, dried at 90°C for 5 hours, and calcined at 1000°C for 3 hours to obtain cerium phosphate (CePO 4 ) powder with a particle size of 50nm to 5μm.

[0084] (3) Take 100 mL of hydrochloric acid solution with a volume fraction of 0.5%, add 4.0 g of collagen, and keep stirring to completely dissolve the collagen until clear and transparent.

[0085] (4) Add 2.0 g of cerium phosphate powder into th...

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Abstract

The invention belongs to the fields of inorganic non-metal materials, organic bioactive polymer materials and biomedical materials, and particularly relates to a rare earth phosphate / bioactive polymerthree-dimensional porous composite material, a preparation method and application thereof. A biologically active polymer material is doped with sheet-like structures of rare earth phosphate particles, the biologically active polymer material and the sheet-like structures of the rare earth phosphate particles are bonded with each other to form a three-dimensional perforated porous channel structure, and the rare earth phosphate is uniformly distributed on the surfaces and insides of the sheet-like structures. The preparation method comprises the following steps of mixing the rare earth phosphate with an acid-containing bioactive polymer material solution, freezing, drying, immersing in an alkali solution, washing to neutrality, freezing, drying, and preparing the material. The structure has high porosity and penetration, good biological activity, biocompatibility, biodegradability and mechanical and mechanical properties, promotes cell adhesion and growth, promotes bone and bone induction, and has broad clinical application prospects.

Description

technical field [0001] The invention belongs to the fields of inorganic non-metallic materials, organic bioactive polymer materials and biomedical materials, and specifically relates to a rare earth phosphate / bioactive polymer three-dimensional porous composite material, its preparation method and application. Background technique [0002] Repair and reconstruction of bone defects remains a great challenge for clinicians, especially large bone defects caused by trauma, infection, injury or genetic malformation. To overcome this problem, many bone repair materials with bone formation activity and osteoinductive ability have been applied clinically. The most common bone repair materials are tricalcium phosphate (β-TCP), hydroxyapatite (HA), bioactive glass (BG) and chitosan (CS), all of which have good bioactivity and biocompatibility , but its limited osteoinductivity cannot meet the treatment needs of patients with osteoporosis and metabolic disorders. Therefore, the devel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/28C08L5/08C08L89/00C08L67/04C08K3/32A61L27/56A61L27/58A61L27/50A61L27/12A61L27/20
CPCA61L27/12A61L27/20A61L27/50A61L27/56A61L27/58A61L2430/02C08J9/28C08J2305/08C08J2367/04C08J2389/00C08K2003/328C08L5/08
Inventor 郭亚平赵培培柯勤飞郭翠香张川建
Owner SHANGHAI NORMAL UNIVERSITY
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