A preparation method and application of tumor catalytic nano -reaction system with targeted tumor function

A nano-reaction and nano-reactor technology, which is applied in the field of preparation of tumor catalytic nano-reaction systems, can solve problems such as the application of tumor catalytic therapy, and achieve excellent tumor-targeting characteristics and good biocompatibility.

Active Publication Date: 2022-08-05
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0003] At present, there are no research reports on the application of GQDs at home and abroad, but there is no application related to the catalytic treatment of tumors.

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  • A preparation method and application of tumor catalytic nano -reaction system with targeted tumor function
  • A preparation method and application of tumor catalytic nano -reaction system with targeted tumor function
  • A preparation method and application of tumor catalytic nano -reaction system with targeted tumor function

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Embodiment Construction

[0031] In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings.

[0032] Preparation Examples:

[0033] This embodiment includes the following steps:

[0034] (1) Using pyrene as a raw material, react pyrene with nitric acid at 80-100°C (preferably 90°C) to prepare a precursor: trinitropyrene, and freeze-dry it; use sodium hydroxide solution to prepare the precursor After resuspension and ultrasonic reaction, the mixture was added to the reactor, and graphene quantum dots (Py-GQDs) were prepared by hydrothermal reaction. The Py-GQDs were dialyzed through ionized water in a dialysis bag and freeze-dried. is ≤3500, the conditions of hydrothermal reaction are 180-200°C (preferably 190°C), 10-12 hours (preferably 11 hours);

[0035] Using carbodiimide / N-hydroxysuccinimide to activate the carboxyl terminus of the Py-GQDs prepare...

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Abstract

The invention discloses a preparation method and application of a tumor catalytic nano-reaction system with tumor-targeting function. The tumor catalytic nano-reaction system includes a tumor catalytic nano-reactor and a tumor-targeting nano-reactor wrapped by physical adsorption outside the tumor catalytic nano-reactor. Materials; the structure of the tumor catalytic nano-reactor is formed by covalently connecting the carboxyl end of the graphene quantum dot with peroxidase activity and the amino end of the glucose oxidase; the tumor-targeting material is formed by amide reaction It is prepared by covalently linking RGDS polypeptide with distearoylphosphatidylethanolamine-polyethylene glycol (DSPE-PEG). The present invention has the characteristics of targeting tumors and at the same time has obvious killing effect on tumor cells, so it can be applied to the preparation of anti-tumor drugs.

Description

technical field [0001] The invention relates to a preparation method and application of a tumor catalysis nano-reaction system with tumor-targeting function. Background technique [0002] Graphene quantum dots (GQDs) are widely used in drug delivery, biosensing, imaging and other fields because of their large specific surface area, abundant and active edge functional groups, and stable autofluorescence. In addition, the study found that GQDs have peroxidase activity similar to horseradish peroxidase, which can degrade hydrogen peroxide into hydroxyl radicals under acidic conditions. Therefore, GQDs are often used to prepare biosensors for glucose detection. [0003] At present, there are no research reports on the application of GQDs at home and abroad, but there is no related application of their catalytic tumor therapy. SUMMARY OF THE INVENTION [0004] The purpose of the present invention is to provide a preparation method and application of a tumor catalysis nano-rea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/44A61K9/51A61K47/18A61K47/62A61P35/00A61K33/44
CPCA61K38/443A61K47/183A61K47/62A61P35/00A61K9/5146A61K33/44C12Y101/03004A61K2300/00
Inventor 齐蕾戴黎明
Owner WENZHOU MEDICAL UNIV
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