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Preparation method and application of tumor-catalyzed nano-reaction system with tumor-targeting function

A technology of nano-reaction and nano-reactor, which is applied in the field of preparation of tumor catalytic nano-reaction system, can solve problems such as the application of tumor catalytic therapy, and achieve excellent tumor-targeting characteristics, no toxic effect, and good biocompatibility Effect

Active Publication Date: 2018-12-28
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] At present, there are no research reports on the application of GQDs at home and abroad, but there is no application related to the catalytic treatment of tumors.

Method used

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  • Preparation method and application of tumor-catalyzed nano-reaction system with tumor-targeting function
  • Preparation method and application of tumor-catalyzed nano-reaction system with tumor-targeting function
  • Preparation method and application of tumor-catalyzed nano-reaction system with tumor-targeting function

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Embodiment Construction

[0031] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0032] Preparation Examples:

[0033] This embodiment includes the following steps:

[0034] (1) Using pyrene as a raw material, react pyrene with nitric acid at 80-100°C (preferably 90°C) to prepare a precursor: trinitropyrene, and freeze-dry it; Resuspension, after ultrasonic reaction, the mixture was added to the reaction kettle, graphene quantum dots (Py-GQDs) were prepared by hydrothermal reaction, and Py-GQDs were dialyzed by ionized water in the dialysis bag and freeze-dried, the molecular weight cut-off of the dialysis bag ≤3500, the condition of hydrothermal reaction is 180-200°C (preferably 190°C), 10-12 hours (preferably 11 hours);

[0035] Tumor catalytic Nanoreactor PyG-Gox (referred to as PG); the mass ratio of Py-GQDs and Gox in this step is 1:1-...

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Abstract

The invention discloses a preparation method and application of a tumor-catalyzed nano-reaction system with a tumor-targeting function. The tumor-catalyzed nano-reaction system comprises a tumor-catalyzed nanoreactor and a tumor targeting material which is physically adsorbed and encapsulated outside the tumor-catalyzed nanoreactor; the structure of the tumor-catalyzed nanoreactor is formed by covalently linking a carboxyl terminal with peroxidase-active graphene quantum dots and an amino terminal of glucose oxidase; the tumor targeting material is prepared by covalently linking RGDS polypeptides with DSPE-PEG through an amide reaction. The tumor-catalyzed nano-reaction system with the tumor-targeting function disclosed by the invention has tumor targeting characteristics and further has obvious killing effect on tumor cells, thereby being capable of being applied to preparation of antitumor drugs.

Description

technical field [0001] The invention relates to a preparation method and application of a tumor-catalyzing nano-reaction system with the function of targeting tumors. Background technique [0002] Graphene quantum dots (GQDs) have a large specific surface area, abundant and active edge functional groups, and stable autofluorescence, so they are widely used in drug delivery, biosensing, imaging and other fields. In addition, the study found that GQDs have a peroxidase activity similar to that of horseradish peroxidase, which can degrade hydrogen peroxide into hydroxyl radicals under acidic conditions. Therefore, GQDs are often used in the preparation of biosensors for glucose detection. [0003] At present, there are no research reports on the application of GQDs at home and abroad, but there is no application related to the catalytic therapy of tumors. Contents of the invention [0004] The purpose of the present invention is to provide a preparation method and applicati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/44A61K9/51A61K47/18A61K47/62A61P35/00A61K33/44
CPCA61K38/443A61K47/183A61K47/62A61P35/00A61K9/5146A61K33/44C12Y101/03004A61K2300/00
Inventor 齐蕾戴黎明
Owner WENZHOU MEDICAL UNIV
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