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Aqueous phase preparation method and application of tylosin tartrate surface molecularly imprinted polymer

A technology of tylosin tartrate and surface molecular imprinting, applied in chemical instruments and methods, water pollutants, other chemical processes, etc., can solve the problems of good regeneration effect, achieve fast mass transfer rate, wide application prospects, transfer The effect of high quality rate

Active Publication Date: 2018-12-18
HENAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the surface molecularly imprinted polymer material prepared by this method has not been reported in the literature, and the imprinted polymer material prepared by the surface polymerization method has regular shape, fast mass transfer speed and good regeneration effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] With 30mL pure water as solvent, tylosin tartrate as template molecule, 0.15g styrene-divinylbenzene particles as carrier, 2-acrylamide-2-methylpropanesulfonic acid and 1,4-butanediyl- 3,3'-bis-1-vinylimidazolium chloride is a functional monomer, pre-polymerized at 30°C for 4 hours, then add cross-linking agent N,N'-methylenebisacrylamide and initiator azobisisobutyronitrile , wherein the molar ratio of template molecules, functional monomers, cross-linking agents and initiators is 1:4:20:0.12, and then thermally initiates the polymerization reaction at 60°C for 24 hours, using a methanol / acetic acid mixture with a volume ratio of 8:2 The template molecules were eluted by Soxhlet extraction for 48 hours, rinsed with methanol, and then vacuum-dried at 60°C to obtain the molecularly imprinted polymer on the surface of tylosin tartrate. The molecularly imprinted polymer on the surface of tylosin tartrate had good Specific adsorption properties.

Embodiment 2

[0025] With 30mL pure water as solvent, tylosin tartrate as template molecule, 0.15g styrene-divinylbenzene particles as carrier, 2-acrylamide-2-methylpropanesulfonic acid and 1,4-butanediyl- 3,3'-bis-1-vinylimidazolium chloride is a functional monomer, pre-polymerized at 30°C for 4 hours, then add cross-linking agent N,N'-methylenebisacrylamide and initiator azobisisobutyronitrile , wherein the molar ratio of template molecules, functional monomers, cross-linking agents and initiators is 1:8:20:0.12, and then thermally initiates the polymerization reaction at 60°C for 24 hours, using a methanol / acetic acid mixture with a volume ratio of 8:2 The template molecules were eluted by Soxhlet extraction for 48 hours, rinsed with methanol, and then vacuum-dried at 60°C to obtain the molecularly imprinted polymer on the surface of tylosin tartrate. The molecularly imprinted polymer on the surface of tylosin tartrate had good Specific adsorption properties.

Embodiment 3

[0027] With 30mL pure water as solvent, tylosin tartrate as template molecule, 0.15g styrene-divinylbenzene particles as carrier, 2-acrylamide-2-methylpropanesulfonic acid and 1,4-butanediyl- 3,3'-bis-1-vinylimidazolium chloride is a functional monomer, pre-polymerized at 30°C for 4 hours, then add cross-linking agent N,N'-methylenebisacrylamide and initiator azobisisobutyronitrile , wherein the molar ratio of template molecules, functional monomers, cross-linking agents and initiators is 1:6:10:0.12, and then thermally initiates the polymerization reaction at 60°C for 24 hours, using a methanol / acetic acid mixture with a volume ratio of 8:2 The template molecules were eluted by Soxhlet extraction for 48 hours, rinsed with methanol, and then vacuum-dried at 60°C to obtain the molecularly imprinted polymer on the surface of tylosin tartrate. The molecularly imprinted polymer on the surface of tylosin tartrate had good Specific adsorption properties.

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PUM

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Abstract

Belonging to the technical field of sample pretreatment and pollutant analysis and detection, the invention discloses an aqueous phase preparation method and application of a tylosin tartrate surfacemolecularly imprinted polymer. The technical scheme includes the key points that: 2-acrylamide-2-methylpropane sulfonic acid and / or 1, 4-butanediyl-3, 3'-bis-1-vinyl imidazolium chloride can be adopted as the functional monomer, tylosin tartrate is taken as the template molecule, pure water is adopted as the preparation solvent, the crosslinking agent N, N'-methylene bisacrylamide and the initiator azobisisobutyronitrile are utilized for thermal initiation of polymerization reaction to prepare the tylosin tartrate surface molecularly imprinted polymer on a styrene-divinyl benzene granular carrier surface. The tylosin tartrate surface molecularly imprinted polymer has action sites for specific recognition of tylosin tartrate, and can be used for selective adsorption of trace tylosin tartrate in environmental samples. According to the invention, the preparation process is simple and the cost is low, and the polymer adsorbent material has uniform particle size, large adsorption capacity and high mass transfer rate.

Description

technical field [0001] The invention belongs to the technical field of sample pretreatment and pollutant analysis and detection, and further belongs to the technical field of preparation of novel surface molecularly imprinted polymers for macrolide antibiotics, in particular to a surface molecularly imprinted polymer of tylosin tartrate Aqueous phase preparation method and application of the compound. Background technique [0002] Antibiotics have a wide antibacterial spectrum, low price and wide application. With the rapid development of antibiotics, the pollution problem has become more and more prominent. Conventional treatment techniques cannot completely remove it, and its trace residue in complex environmental media will cause great harm to the ecosystem and human health. [0003] Macrolide antibiotics are a general term for antibiotics with a large lactone ring skeleton structure. They resist Gram-positive and Gram-negative bacteria by inhibiting the synthesis of bac...

Claims

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Application Information

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IPC IPC(8): C08F257/02C08F220/58C08F222/38C08F226/06B01J20/26B01J20/281B01J20/30C02F1/28C02F101/38
CPCB01J20/268B01J20/281B01J20/30C02F1/285C02F2101/38C08F257/02C08F220/585
Inventor 朱桂芬王利芳逯通李宛宛程国浩王培云陈乐田王艺聪樊静
Owner HENAN NORMAL UNIV
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