Immunogenic polysaccharide vaccine and identification method thereof
An immunogenic, polysaccharide technology, applied in the medical field, can solve the problems of excessive sample molecular weight, difficult to form a precipitation line, affecting the test effect, etc., and achieve the effect of high sensitivity and good specificity.
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Embodiment 1
[0064] The invention provides an immunogenic polysaccharide, the polysaccharide is identified through the turbidimetry of the immunization rate, and the turbidimetry of the immunization rate at least includes contacting the polysaccharide solution with the corresponding antibody to form an antigen-antibody complex, The value of the reaction rate of antigen-antibody complex was determined by nephelometric scattering.
[0065] In the further optimized technical scheme of the present invention, the immunogenic polysaccharides include capsular polysaccharides of any serogroup of Neisseria meningitidis, capsular polysaccharides of any serotype of Haemophilus influenzae, Vi polysaccharides of Salmonella typhi, Staphylococcus aureus Capsular polysaccharide of any serotype, capsular polysaccharide of any serotype of Cryptococcus, capsular polysaccharide of any serogroup of Streptococcus, capsular polysaccharide of any serogroup of Clostridium difficile, capsular polysaccharide of any ser...
Embodiment 2
[0080] The present invention provides a polysaccharide vaccine prepared from immunogenic polysaccharides. The polysaccharide vaccine is identified through the turbidimetry of the immune rate, and the immune rate turbidimetry at least includes contacting the polysaccharide vaccine with the corresponding antibody to form an antigen-antibody complex , and then the reaction rate value of the antigen-antibody complex was determined by immune rate scattering turbidimetry. In other words, polysaccharide vaccines are identified by using the rate unit value measured by the specific combination of antigen and antibody to form an antigen-antibody complex.
[0081] In the further optimized technical scheme of the present invention, the polysaccharide in the polysaccharide vaccine includes any serogroup capsular polysaccharide of Neisseria meningitidis, any serotype capsular polysaccharide of Haemophilus influenzae, Salmonella typhi Vi polysaccharide, Staphylococcus aureus Capsular polysac...
Embodiment 3
[0096] (1) Sample source Meningococcal serogroups A, C, Y, W135 capsular polysaccharides, Haemophilus influenzae serotype b capsular polysaccharides, and reference tetanus toxoid were purchased from NIBSC (National Institute for the Control of Biological Products, UK) , Meningococcal serogroups A, C, Y, W135 antiserum were purchased from BD Biological Company, and typhoid Vi polysaccharide antiserum was purchased from China National Institutes for Food and Drug Control.
[0097] (2) Prepare meningococcal serogroups A, C, Y, W135 capsular polysaccharides, group A meningococcal polysaccharide vaccines, group C meningococcal polysaccharide vaccines, group A Group C meningococcal polysaccharide vaccine, ACYW135 group meningococcal polysaccharide vaccine, typhoid Vi polysaccharide and its vaccine are prepared according to the method published in Chinese patent CN201110171746.5.
[0098] (3) According to the items and methods specified in the Pharmacopoeia of the People's Republic o...
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