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Medical titanium alloy bar with anti-bacterial function and osteoinductive activity

A titanium alloy, osteoinductive technology, applied in metal material coating technology, medical science, ion implantation plating, etc., can solve the problem of not promoting blood coagulation and wound healing, not promoting blood coagulation and wound healing, not solving wear resistance problems such as biocompatibility and osteoinductive activity, promoting blood coagulation and wound healing, and improving thermodynamic stability

Inactive Publication Date: 2018-12-07
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the application of new titanium alloy medical materials has the following deficiencies: ①The integration between titanium alloy and bone is only a kind of mechanical interlocking integration. Local tissue inflammation shortens its service life; ② has certain biocompatibility, but does not have osteoinductive activity; ③ has no antibacterial properties; ④ does not have the effect of promoting blood coagulation and wound healing
[0005] The domestic patent application No. 201510508585.2 discloses a preparation method of a medical bone fixation device, but does not solve the problem of wear resistance; the application No. 201710979298.9 discloses a medical titanium alloy and its preparation method, which has good wear resistance, but does not have Osteoinductive activity; application number 201510476616.0 published a medical titanium alloy rod, and application number 201510476615.6 published a medical titanium alloy rod with strong antibacterial ability. Both patented technologies are coated on the outer layer of the titanium alloy rod Coating, but no osteoinductive activity, nor promote blood coagulation and wound healing

Method used

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  • Medical titanium alloy bar with anti-bacterial function and osteoinductive activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) Preparation of titanium alloy ingot: the chemical composition of the titanium alloy ingot is calculated by mass percentage: W 2.0%, Zn 4.0%, Fe 2%, Mo0.7%, Sr 0.5%, Se 1.2%, Sn 0.6%, the balance is Ti;

[0027] Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 － 4 Pa, the argon gas with a purity of 99.99% was introduced for 3 times of repeated gas scrubbing, and then smelted with electricity (temperature 1800°C, holding time 60 minutes) and cast into an ingot, and the ingot was turned over 180° and remelted 5 times to ensure the uniformity of the composition;

[0028] 2) Deformation processing: Coat a layer of hexagonal boron nitride on the surface of the ingot to prevent oxidation and increase lubrication during high-temperature processing, keep the ingot coated with hexagonal boron nitride at 850-1150°C for 2.5h, and then carry out free forging , the final forging...

Embodiment 2

[0039] 1) Preparation of titanium alloy ingot: the chemical composition of the titanium alloy ingot is calculated by mass percentage: W 2.2%, Zn 4.5%, Fe2.2%, Mo0.8%, Sr 0.6%, Se 1.5%, Sn 0.7%, the balance is Ti;

[0040] Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 － 4 Pa, the argon gas with a purity of 99.99% was introduced for 3 times of repeated gas scrubbing, and then smelted with electricity (temperature 1800°C, holding time 60 minutes) and cast into an ingot, and the ingot was turned over 180° and remelted 5 times to ensure the uniformity of the composition;

[0041] 2) Deformation processing: Coat a layer of hexagonal boron nitride on the surface of the ingot to prevent oxidation and increase lubrication during high-temperature processing, keep the ingot coated with hexagonal boron nitride at 850-1150°C for 2.5h, and then carry out free forging , the final forgin...

Embodiment 3

[0052] 1) Preparation of titanium alloy ingot: the chemical composition of the titanium alloy ingot by mass percentage is: W 3.2%, Zn6%, Fe 4.8%, Mo 1.1%, Sr 0.8%, Se 0.9%, Sn 0.8% , the balance is Ti;

[0053] Put the prepared raw materials into the non-consumable electrode water-cooled copper crucible electric arc furnace, and evacuate the furnace to 8.5×10 － 4 Pa, the argon gas with a purity of 99.99% was introduced for 3 times of repeated gas scrubbing, and then smelted with electricity (temperature 1800°C, holding time 60 minutes) and cast into an ingot, and the ingot was turned over 180° and remelted 5 times to ensure the uniformity of the composition;

[0054] 2) Deformation processing: Coat a layer of hexagonal boron nitride on the surface of the ingot to prevent oxidation and increase lubrication during high-temperature processing, keep the ingot coated with hexagonal boron nitride at 850-1150°C for 2.5h, and then carry out free forging , the final forging temperatu...

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Abstract

The invention provides a medical titanium alloy bar with an anti-bacterial function and osteoinductive activity. The medical titanium alloy bar with the anti-bacterial function and osteoinductive activity comprises a titanium alloy bar body, an ion implantation layer and an external coating. The titanium alloy bar body comprises, by mass, 2.0%-5.0% of W, 3%-8% of Zn, 2%-6% of Fe, 0.5%-1.2% of Mo,0.5%-1.0% of Sr, 0.5%-1.2% of Se, 0.4%-1.0% of Sn, and the balance Ti. The ion implantation layer is a silver ion implantation layer. The external coating comprises, by mass, 15%-25% of nano beta-Ca3(PO4)2 composite particles and nano CaCo3 composite particles (the mass ratio of the beta-Ca3(PO4)2 composite particles to the nano CaCo3 composite particles is 1:1), and the balance chitosan. The medical titanium alloy bar has excellent mechanical properties, the anti-bacterium function, good biocompatibility and remarkable osteoinductive activity and can promote blood coagulation and wood healing.

Description

technical field [0001] The invention belongs to the technical field of new medical materials, in particular to a medical titanium alloy rod with antibacterial and osteoinductive functions. Background technique [0002] Metals, ceramics and polymer materials are the three major medical artificial bone and joint materials today, and each of the three materials has its advantages and disadvantages. Metals and ceramics have been widely used in the field of load-bearing medicine, but metals are prone to wear and corrosion, while ceramics are brittle, and polymer materials have good flexibility but poor wear resistance and hardness. With the development of modern medicine and materials science, metal materials have become the most widely used clinical implant materials due to their good mechanical properties and processing properties. Titanium alloys have been widely used due to their excellent mechanical properties and good biocompatibility. Wide range of applications. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22F1/18C23C4/04C23C4/134C23C4/14C23C14/02C23C14/16C23C14/48C22C14/00C22C1/02A61L27/04A61L27/06A61L27/30A61L27/32A61L27/34A61L27/54A61L27/58B21J1/04B21J3/00
CPCA61L27/04A61L27/06A61L27/306A61L27/32A61L27/34A61L27/54A61L27/58A61L2300/104A61L2300/404A61L2420/02A61L2420/06A61L2430/02A61L2430/24B21J1/04B21J3/00C22C1/02C22C14/00C22F1/183C23C4/04C23C4/134C23C4/14C23C14/021C23C14/16C23C14/48C08L5/08
Inventor 李宇谷晨熙许建中田科张弛孙俊魁郝钢
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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