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Composition and testing method for treating dysfunctional uterine bleeding

A technology for uterine bleeding and therapeutic functions, which is applied in the direction of drug combination, disease, blood disease, etc., and can solve problems such as rough workmanship

Active Publication Date: 2021-09-03
SUZHOU DAIZETANG NATURAL PROD R&D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the traditional Chinese medicine Gujing Wan in the "Chinese Pharmacopoeia": tortoise shell, white peony root, scutellaria baicalensis, Phellodendron chinensis, chrysanthemum root bark, Cyperus cyperi 6 herbs are powdered into pills, the process is rough, and only the antibacterial ingredient berberine content is tested, not Promote the recovery of endometrium, anti-inflammation, hemostasis and other components related to the treatment of DUB

Method used

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  • Composition and testing method for treating dysfunctional uterine bleeding
  • Composition and testing method for treating dysfunctional uterine bleeding
  • Composition and testing method for treating dysfunctional uterine bleeding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 composition

[0033] Tortoise shell: raw rehmannia root: white peony root: raw cattail: root bark of Chinese tortoiseshell The weight ratio is 5-20: 15-60: 5-20: 6-18: 3-18, the best composition of this granule is tortoise shell: raw rehmannia : Paeoniae Alba: Raw Puhuang: Toon root bark is 15:30:15:10:9. The results are shown in the table below.

[0034] Pilot Test 1 Tortoise shell: Rehmannia glutinosa: Radix Paeoniae Alba: Raw cattail: Radix chinensis root bark is 15:30:15:10:9kg, the preparation process is based on the raw drug ratio, and the rehmannia root and tortoise shell are decocted and extracted (20 times the water in total, 0.5 hour, decocted twice), the medicinal liquid is filtered, the filtrate is adjusted to nearly neutral, concentrated into a thick paste of 2.0g crude drug / ml, sinking in water for 2 days, and the supernatant is taken to obtain an extract; Peony 70% ethanol 10 times the amount of medicinal material percola...

Embodiment 2

[0040] The active ingredient detection of embodiment 2 composition

[0041] Three batches of pilot test extracts in the above-mentioned embodiment 1 have been carried out active ingredient detection, and formulated the quality standard of product, as follows:

[0042] 1 Technical requirements

[0043] 1.1 Appearance This product is dark yellow liquid.

[0044] 1.2 Physical and chemical requirements

[0045] Table 2 Physical and Chemical Requirements Standards

[0046]

[0047] 2 Experimental methods

[0048] 2.1 pH: Measure the 10% aqueous solution of the sample with an acidity meter.

[0049] 2.2 Total flavonoids: take 10ml of this product solution to a 100ml volumetric flask, and dilute to volume with 50% methanol, respectively take the solution, rutin reference substance, and 2.0ml of 50% methanol, put them in a 25ml volumetric flask, add water to 10ml, add 1ml of 5% Sodium nitrite solution, add 1ml 10% aluminum nitrate solution, shake well and let stand for 5 minut...

Embodiment 3

[0060] The detection of the effect of embodiment 3 composition treatment function blood

[0061] According to the following experimental procedures, for the sample of Pilot Test 1 in Example 1, the DUB rat model was replicated by using misoprostol combined with mifepristone to test the effect of DB treatment.

[0062] 1 Experimental materials

[0063] 1.1 Experimental Drugs and Reagents

[0064] Pilot test 1 described in Example 1

[0065] Gongxuening capsule, Yunnan Baiyao Group Co., Ltd., batch number: Z112021.

[0066] Misoprostol tablets (200ug / tablet), British Pharma healthcare company, batch number: A06332.

[0067] Mifepristone tablets (10mg / tablet), Zhejiang Xianju Pharmaceutical Co., Ltd., batch number: 121201.

[0068] Estradiol ELISA kit, Nanjing Senbega Biotechnology Co., Ltd., batch number: SBJ-R0048.

[0069] Progesterone ELISA kit, Nanjing Senbega Biotechnology Co., Ltd., batch number: SBJ-R1043.

[0070] TT kit, Beijing Shidi Scientific Instrument Co., Lt...

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Abstract

Provided is a pharmaceutical composition for treating dysfunctional uterine bleeding, which contains an active ingredient and a pharmaceutically acceptable carrier. The ratio is 5‑20:15‑60:5‑20:6‑18:3‑18. The preparation method of the pharmaceutical composition and its application in the preparation of medicines for treating dysfunctional uterine bleeding are also disclosed.

Description

technical field Background technique [0001] Dysfunctional uterine bleeding (abbreviated as DUB) refers to abnormal uterine bleeding caused by neuroendocrine dysfunction of the hypothalamus-pituitary-ovary axis. Modern medicine treats this disease with hormones, hemostatic drugs and uterine curettage. Traditional Chinese medicine has unique advantages in treating this disease, but it often uses large compound decoctions, which is inconvenient for clinical use. Keel 24g, oyster 24g, cornus 24g, sea octopus 12g, fried astragalus 18g, madder 9g, gall 1.5g, fried Atractylodes macrocephala 12g, brown edge charcoal 6g, 130g decoction of 9 flavors of the whole prescription. Existing patented medicines are also less, quality control indicators are not clear, and drug efficacy is unstable. For example, the traditional Chinese medicine Gujing Wan in the "Chinese Pharmacopoeia": tortoise shell, white peony root, scutellaria baicalensis, Phellodendron chinensis, chrysanthemum root bark,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/88G01N30/02G01N21/31G01N1/38A61P15/00A61P7/04
CPCA61K35/586A61K36/185A61K36/65A61K36/71A61K36/804A61K36/88A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53G01N1/38G01N21/314G01N30/02A61K2300/00
Inventor 许小凤徐丽华
Owner SUZHOU DAIZETANG NATURAL PROD R&D CO LTD
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