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A colon-targeted capsule for treating ulcerative colitis and its preparation process

A colon-targeting technology for ulcerative colitis, applied in the field of medicine, can solve problems such as inability to reach the ulcer lesion area, insignificant treatment effect, and safety to be investigated, so as to improve gastrointestinal function, good treatment effect, and patient compliance good sex effect

Active Publication Date: 2022-03-04
苏州玉森新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ordinary decoctions, powders, etc. are not only inconvenient to take, but each dose is large, and after oral administration, the drug has been absorbed or degraded by the whole body before reaching the colon; In the rectum and descending colon, it cannot reach the main ulcer lesion areas such as the transverse colon and ascending colon, which affects the efficacy of the drug
In addition, although acupuncture and moxibustion therapy such as acupuncture, acupoint catgut embedding, and acupoint application have been applied, the therapeutic effect is not significant, individual differences are large, recurrence is easy, and the safety needs to be investigated.

Method used

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  • A colon-targeted capsule for treating ulcerative colitis and its preparation process
  • A colon-targeted capsule for treating ulcerative colitis and its preparation process
  • A colon-targeted capsule for treating ulcerative colitis and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of Atractylodes Rhizome Volatile Oil Cyclodextrin Inclusion Compound

[0050] Take 3mL of Atractylodes macrocephala volatile oil and add an equal volume of absolute ethanol to make a mixed solution of Atractylodes macrocephala volatile oil and ethanol for use; weigh 18g of β-cyclodextrin, dissolve it in 180g of distilled water, stir in a constant temperature water bath at 30°C, and add Atractylodes macrocephala dropwise at the same time The mixed solution of volatile oil and ethanol was stirred at constant temperature for 1.5h, cooled to room temperature, refrigerated at 4°C for 24h, filtered with suction, washed with absolute ethanol three times, 5mL each time, and the obtained precipitate was dried in an oven at 40°C to obtain the dry clathrate.

Embodiment 2

[0051] Example 2 Preparation of Atractylodes Rhizome Volatile Oil Cyclodextrin Inclusion Compound

[0052] Take 3mL of Atractylodes macrocephala volatile oil and add an equal volume of absolute ethanol to make a mixed solution of Atractylodes macrocephala volatile oil and ethanol for use; weigh 24g of β-cyclodextrin, dissolve it in 360g of distilled water, stir in a constant temperature water bath at 40°C, and add Atractylodes macrocephala dropwise The mixed solution of volatile oil and ethanol was stirred at constant temperature for 1 h, cooled to room temperature, refrigerated at 4°C for 24 h, filtered with suction, washed with absolute ethanol three times, 5 mL each time, and the obtained precipitate was dried in an oven at 40°C to obtain the dry clathrate.

Embodiment 3

[0053] Example 3 Preparation of Atractylodes Rhizome Volatile Oil Cyclodextrin Inclusion Compound

[0054] Take 3mL of Atractylodes macrocephala volatile oil and add an equal volume of absolute ethanol to make a mixed solution of Atractylodes macrocephala volatile oil and ethanol for use; weigh 30g of β-cyclodextrin, dissolve it in 600g of distilled water, stir in a constant temperature water bath at 50°C, and add Atractylodes macrocephala dropwise The mixed solution of volatile oil and ethanol was stirred at constant temperature for 2h, cooled to room temperature, refrigerated at 4°C for 24h, filtered with suction, washed with absolute ethanol three times, 5mL each time, and the obtained precipitate was dried in an oven at 40°C to obtain the dry clathrate.

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Abstract

The invention relates to the technical field of medicine, in particular to a colon-targeted capsule for treating ulcerative colitis and a preparation process thereof. Composed of 10-20 parts of pellets, the stomach-soluble pellets are composed of Atractylodes macrocephala volatile oil, β-cyclodextrin and pilling accelerator, etc. and colon-targeted coating material. The colon-targeted capsule of the present invention has the characteristics of treating both symptoms and root causes, high bioavailability, and releasing different components in the stomach and colon respectively, and has the advantages of safe and convenient oral administration, simple coating prescription, and industrial production. Animal experiments show that the colon-targeting capsule has obvious therapeutic effect on ulcerative colitis, and the therapeutic effect of the medium dose is close to or even better than that of the positive control drug SASP, which provides a brand-new preparation for clinical treatment of ulcerative colitis.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a prescription of a colon-targeted capsule for treating ulcerative colitis and a preparation process thereof. Background technique [0002] Ulcerative colitis (UC), also known as chronic nonspecific ulcerative colitis, is a common autoimmune disease. Its clinical manifestations are mainly digestive system symptoms, including abdominal pain, diarrhea, mucus pus and blood in the stool, and tenesmus. The course of the disease is protracted and difficult to heal, ranging from several months to decades, often recurrent, and severe cases can cause colon cancer. Infection, mental, genetic, immune, environmental and other factors can induce ulcerative colitis. With the acceleration of the pace of life in modern society, the aggravation of survival pressure, and the change of diet structure, the incidence of the disease is increasing year by year. According to statistics, the inciden...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K9/16A61K9/50A61K36/736A61P1/04A61P1/00A61P29/00A61P37/02
CPCA61P1/00A61P1/04A61P29/00A61P37/02A61K9/1652A61K9/5026A61K9/5047A61K36/238A61K36/284A61K36/718A61K36/736A61K2300/00
Inventor 刘继勇唐晓萌岳小强王婷顾永卫杨盟顾清
Owner 苏州玉森新药开发有限公司
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