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Aromatic amine functionalized metal-organic framework material based on fluorescence for detection of lactose molecule and preparation method of aromatic amine functionalized metal-organic framework material

A fluorescence detection, organic framework technology, applied in analytical materials, luminescent materials, chemical instruments and methods, etc., can solve the problems of the urgency of lactose molecular probes, the need to improve detection methods, and the lack of lactose detection, to expand the design range, easy to Large-scale preparation, low cost effect

Active Publication Date: 2018-11-23
XUZHOU NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] 1. Most fluorescent probes based on organic ligands are generally affected by solubility, and are generally suitable for organic solvents or organic / water mixed solvent systems. Therefore, it is still necessary to develop detection methods for recognizing lactose molecules in pure water systems. needs improvement
[0005] 2. Some probes that have been reported are often limited by the interference of other monosaccharide and disaccharide molecules, such as glucose and maltose, on the recognition process. It is urgent to design simple, cheap, efficient and specific lactose molecular probes. Significance
[0006] 3. For most of the reported lactose probes, only the detection of lactose molecules in the experimental analysis process is realized, and the detection of lactose in actual dairy products is relatively small. Therefore, a case of lactose probe material with practical application potential is developed has great significance

Method used

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  • Aromatic amine functionalized metal-organic framework material based on fluorescence for detection of lactose molecule and preparation method of aromatic amine functionalized metal-organic framework material
  • Aromatic amine functionalized metal-organic framework material based on fluorescence for detection of lactose molecule and preparation method of aromatic amine functionalized metal-organic framework material
  • Aromatic amine functionalized metal-organic framework material based on fluorescence for detection of lactose molecule and preparation method of aromatic amine functionalized metal-organic framework material

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Experimental program
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Effect test

Embodiment 1

[0042]Weigh 1.8mg 3,3'-((3,4-dioxo-1-ene-1,2-diyl)bis(azanediyl))dibenzoic acid (H 2 dbda) (5.1mM), 0.9mg 4,4'-Bipyridine (bpy) (5.7mM), 1.6mg Co(NO 3 ) 2 ·6H 2 O (5.5mM), placed in a 10mL glass sample vial, add 2mL of N,N-dimethylacetamide / ethanol (volume ratio is 1:1) mixed solvent, then place the glass sample vial in hydrothermal synthesis In the reaction kettle, place the hydrothermal synthesis reaction kettle in an electric blast drying oven at a constant temperature of 80°C, and react for three days. After the reaction is completed, cool down to obtain red blocky crystals, filter, wash with ethanol for 5 times, and dry at room temperature for 36 hours. , the metal-organic framework material Co-DBPY was prepared, the yield: 73%. C 28 h 18 CoN 4 o 6 N 9.90%. Found: C 59.44; H 3.27; N 9.87%. Its crystal structure is as figure 1 As shown, it can be seen that the structure has an approximately rectangular channel, and the aromatic amine part is located in the channel...

Embodiment 2

[0054] Weigh 1.8mg H 2 dbda(5.1mM), 0.8mg bpy(5.1mM), 1.5mg Co(NO 3 ) 2 ·6H 2 O (5.1mM), placed in a 10mL glass sample vial, add 2mL of N,N-dimethylacetamide / ethanol (volume ratio is 1:1) mixed solvent, then place the glass sample vial in hydrothermal synthesis In the reaction kettle, place the hydrothermal synthesis reaction kettle in an electric blast drying oven at a constant temperature of 75°C and react for 70 hours. After the reaction is completed, cool down to obtain red blocky crystals, filter, wash with ethanol for 3 times, and dry at room temperature for 5 hours. The metal-organic framework material Co-DBPY was prepared.

Embodiment 3

[0056] Weigh 1.8mg H 2 dbda(5.1mM), 0.8mg bpy(5.1mM), 1.8mg Co(NO 3 ) 2 ·6H 2 O (6.1Mm), placed in a 10mL glass sample bottle, add 2mL of N,N-dimethylacetamide / ethanol (volume ratio is 1:1) mixed solvent, then put the glass sample bottle in hydrothermal synthesis In the reaction kettle, place the hydrothermal synthesis reaction kettle in an electric blast drying oven, keep the temperature at 75°C, and react for 74 hours. After the reaction is completed, cool down to obtain red blocky crystals, filter, wash with ethanol for 3 times, and dry at room temperature for 36 hours. The metal-organic framework material Co-DBPY was prepared.

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Abstract

The invention discloses an aromatic amine functionalized metal-organic framework material based on fluorescence for detection of lactose molecules and a preparation method of the metal-organic framework material. The metal-organic framework material is prepared by a hydrothermal reaction with metal ion Co2+ as a node, and 3,3'-((3,4-dioxo-1-ene-1,2-diyl)bis(azanediyl)) benzoic acid and 4,4'-bipyridyl as organic linking ligands; a chemical formula of the material is: [Mm(L1)n(L2)p.(H2O)q], wherein L1 is H2dbda, L2 is bpy, M is the metal ion Co2+, m=1, n=1, p=1, and q=1; the material provided bythe invention has high selectivity for detection of lactose molecules in common monosaccharide and disaccharide molecules, and can be used for detecting lactose molecules in liquid milk; the preparation process of the material is simple, environmentally friendly, low in cost, and easy to be prepared on a large scale.

Description

technical field [0001] The invention relates to the field of metal-organic framework materials, in particular to an aromatic amine functionalized metal-organic framework material based on fluorescent detection of lactose molecules and a preparation method thereof. Background technique [0002] As one of the nutritional elements closely related to the intellectual development of young children, lactose can promote the production of cerebrosides and mucopolysaccharides, and the absence or reduction of lactase activity in milk leads to the clinical syndrome "lactose intolerance". "Lactose intolerance" is accompanied by various physical symptoms, such as diarrhea, nausea, excessive intestinal gas, cramps, etc., which are serious hazards. Therefore, in order to detect the intake of lactose, it is of great significance to develop simple, efficient, sensitive and specific probe materials for lactose molecules, especially lactose in dairy products, in the detection of dairy products...

Claims

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Application Information

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IPC IPC(8): C07F15/06C09K11/06G01N21/64
CPCC07F15/065C09K11/06C09K2211/187G01N21/6428
Inventor 武鹏彦蒋敏马菊田雪琴王健
Owner XUZHOU NORMAL UNIVERSITY
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