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Hyaluronic acid-modified polypyrrole-wrapped medicine-carrying phase-change material photo-thermal treatment agent and preparation method thereof

A hyaluronic acid modification and photothermal therapeutic agent technology, applied in the field of medical drugs, can solve the problems of cumbersome synthesis process, non-biodegradable long-term cytotoxic clinical application, etc., and achieve the effect of low toxicity

Active Publication Date: 2018-11-16
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the light-sensitive nanomaterials reported in the literature include gold nanoparticles, carbon nanoparticles, and copper sulfide nanoparticles with various structures. Although these inorganic nanomaterials have shown remarkable photothermal conversion efficiency in previous studies, they are cumbersome However, problems such as non-biodegradable and potential long-term cytotoxicity hinder its further clinical application

Method used

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  • Hyaluronic acid-modified polypyrrole-wrapped medicine-carrying phase-change material photo-thermal treatment agent and preparation method thereof
  • Hyaluronic acid-modified polypyrrole-wrapped medicine-carrying phase-change material photo-thermal treatment agent and preparation method thereof
  • Hyaluronic acid-modified polypyrrole-wrapped medicine-carrying phase-change material photo-thermal treatment agent and preparation method thereof

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Embodiment 1

[0026] 1. Preparation of drug-loaded phase change material lipid nanoparticles

[0027] Dissolve lauric acid and stearic acid (w / w:4 / 1) in dichloromethane to prepare a phase change material solution with a concentration of 4 mg / mL. Accurately weigh 30.0 mg of soybean lecithin and 3.0 mg of docetaxel into a 10 mL round bottom flask, add 1.2 mL of the above phase change material solution, and then evaporate to form a film. Then, 3.6 mL of distilled water was added, ultrasonicated in a water bath at 50° C. for about 2 min, and rapidly cooled in an ice bath to obtain lipid nanoparticles loaded with drugs.

[0028] 2. Preparation of polypyrrole-coated drug-loaded phase change material photothermal therapeutic agent

[0029] The cooled drug-loaded phase-change material lipid nanoparticles were stirred for 10 min in an ice-bath environment, and then 0.75 mL of polyvinyl alcohol solution (100 mg / mL) and 0.75 mL of ferric chloride solution (150 mg / mL) were added, After stirring for a...

Embodiment 2

[0034]1. In vitro photothermal effect detection of hyaluronic acid-modified polypyrrole-coated drug-loaded phase change material photothermal therapeutic agent

[0035] A fiber-coupled output laser was used to investigate the photothermal effect of hyaluronic acid-modified polypyrrole-coated drug-loaded phase-change material photothermal therapeutic agent suspension. 2.0mg / mL), measure 2mL of different concentrations of nano-suspension in a quartz cuvette, at a power density of 1.0W / cm 2 The near infrared laser (808nm) was irradiated for 10 minutes, and the temperature change of the sample was recorded at the same time, and the deionized water without nanosuspension was used as a blank control. From Figure 4 It can be seen that the temperature change of the control group is not obvious, which indicates that the laser radiation alone cannot significantly increase the temperature. On the contrary, the temperature rise performance of the nanosuspension is concentration-depende...

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Abstract

The invention discloses a hyaluronic acid-modified polypyrrole-wrapped medicine-carrying phase-change material photo-thermal treatment agent and a preparation method thereof. The photo-thermal treatment agent is prepared from a medicine-carrying phase-change material core, a polypyrrole shell and hyaluronic acid which is adsorbed on the surface of the polypyrrole shell layer. The photo-thermal treatment agent prepared through the invention has uniform shape and uniform size, is about 233 nm in particle size, and can be targeted to tumor part; meanwhile, the phase-change material core can makea response to temperature change, and presents temperature-sensitive medicament release. The hyaluronic acid-modified polypyrrole-wrapped medicine-carrying phase-change material photo-thermal treatment agent has high photothermal conversion efficiency, a good opto-acoustic developing effect, a targeted tumor chemotherapy-photothermal therapy synergistic effect after the anti-tumor medicament is loaded, is enhanced on the aspect of the tumor treatment effect, and has a good application prospect.

Description

technical field [0001] The invention relates to the field of medical medicine, in particular to a hyaluronic acid-modified polypyrrole-coated drug-loaded phase-change material photothermal therapeutic agent and a preparation method thereof. Background technique [0002] In recent years, stimuli-responsive nano drug delivery systems have attracted more and more attention of researchers in the field of tumor therapy research. The stimulus that triggers the stimuli-responsive nano-delivery system can be internal or external. According to the homeostasis of the cell, the internal stimulus can be redox, enzyme, pH, etc., and the external stimulus can be magnetic resonance, light, ultrasound, temperature, electric field, etc. The anti-tumor drug delivery platform constructed based on these internal or external stimuli can achieve controlled drug release at the lesion site by changing the pharmacokinetic and pharmacodynamic parameters, improve the bioavailability of the drug, ther...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/33A61K49/22A61K47/36A61P35/00A61K31/337
CPCA61K31/337A61K41/0057A61K47/36A61K49/22A61P35/00A61K2300/00
Inventor 张良珂赵庭
Owner CHONGQING MEDICAL UNIVERSITY
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