Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of lysine acetate bulk drug

A technology of lysine acetate and lysine hydrochloride, which is applied in the field of amino acid preparation, can solve the problems of insufficient environmental protection of ammonia gas, high energy consumption of ammonia, and environmental pollution, and facilitate industrial scale-up, reduce water consumption, and shorten concentration time Effect

Active Publication Date: 2021-03-02
WUXI JINGHAI AMINO ACID
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the whole process, elution of lysine consumes a large amount of ammonia water, and the subsequent heating and vacuum concentration to catch ammonia consumes high energy consumption, and the volatilization of a large amount of ammonia gas is not environmentally friendly; the elution and regeneration process of the detachable column requires strong alkali and strong acid solution, and the elution of lysine also requires the use of a large amount of ammonia solution
Strong alkali, strong acid and ammonia solution are not environmentally friendly and can easily cause environmental pollution

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 lysine acetate

[0043] (1) After dissolving 10kg of lysine hydrochloride in water, the diluted solubility is 20% (g / 100ml water). The aqueous solution of lysine hydrochloride is electrodialyzed with a special heterogeneous metal film (EPL4016C of Hangzhou Lanran Environmental Technology Co., Ltd. ) Dechlorination, the volume of the clear solution after dechlorination is twice the volume of the concentrated solution, the conductivity of the clear solution after dechlorination is ≤400μs / cm, and the yield is ≥99%;

[0044] (2) Add the concentrated lysine solution into a 100L reaction kettle, add glacial acetic acid with the same number of moles as lysine, adjust the pH value to 7.0, and react at 70-80°C for 2 hours to obtain a lysine acetate solution ;

[0045] (3) Regulate the pH of the lysine acetate aqueous solution to be 4.0 to obtain the lysine acetate feed liquid;

[0046] (4) Ammonium acetate is first added to the lysine acetate fe...

Embodiment 2

[0051] The preparation of embodiment 2 lysine acetate

[0052](1) After lysine hydrochloride 10kg is dissolved in water, the solubility after dilution is 20%. The aqueous solution of lysine hydrochloride is dechlorinated by electrodialysis special heterogeneous metal membrane. 2 times, the clear night conductivity after dechlorination is ≤350μs / cm, and the yield is ≥98%;

[0053] (2) Add the lysine solution into a 100L reaction kettle, add glacial acetic acid with 1.1 times the molar number of lysine, and adjust the pH value to 7.0, and react at 70-80°C for 2 hours to obtain a lysine acetate solution;

[0054] (3) Regulate the pH of the lysine acetate aqueous solution to be 3.0 to obtain the lysine acetate feed liquid;

[0055] (4) Ammonium acetate is first added in the lysine acetate feed solution, so that the mass ratio of the inorganic salt to the final concentration is 20%, and then ethanol is added so that the mass ratio of the organic solvent to the final concentration ...

Embodiment 3

[0060] The preparation of embodiment 3 lysine acetate

[0061] (1) After lysine hydrochloride 10kg is dissolved in water, the solubility after dilution is 20%. The lysine hydrochloride aqueous solution is dechlorinated by electrodialysis special heterogeneous metal membrane. The clear volume after dechlorination is 2% of the dope volume times, the clear night conductivity after dechlorination is ≤300μs / cm, and the yield is ≥97%;

[0062] (2) Add the lysine solution into a 100L reaction kettle, add glacial acetic acid with 1.2 times the molar number of lysine, and adjust the pH value to 7.0, and react at 70-80°C for 2 hours to obtain a lysine acetate solution;

[0063] (3) Regulate the pH of the lysine acetate aqueous solution to be 5.0 to obtain the lysine acetate feed liquid;

[0064] (4) Ammonium acetate is first added in the lysine acetate feed solution, so that the mass ratio of the inorganic salt to the final concentration is 20%, and then ethanol is added so that the ma...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
transmittivityaaaaaaaaaa
transmittivityaaaaaaaaaa
transmittivityaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a lysine acetate bulk drug, which belongs to the technical field of amino acid preparation. The invention abandons the traditional method for dechlorination of ion exchange column, does not need to use solutions such as acid-base, ammonia water, etc., and reduces the pollution to the environment; Compared with traditional ion exchange extraction methods, wastewater generation and acid-base consumption are further eliminated. The product recovery rate of the lysine acetate crude drug obtained by the method of the invention can be as high as 99.8%, the product purity can be as high as 99.7%, and the light transmittance can be as high as 99.8%.

Description

technical field [0001] The invention relates to a preparation method of a lysine acetate bulk drug, belonging to the technical field of amino acid preparation. Background technique [0002] L-Lysine is one of the essential amino acids for the human body, because it is not only a basic nutrient for human health, but also has anti-inflammatory and analgesic effects, liver cell protection, immunity enhancement, and anti-tumor effects in disease treatment. . Medical compound amino acid injection can not only provide patients with essential nutrients, but also has good effects in treating burns, liver diseases, kidney diseases, encephalopathy, etc. Lysine is one of the main raw materials for compound amino acid injection. Due to the poor chemical stability of lysine, it was often used as lysine hydrochloride in the early stage. The compound amino acid infusion prepared with lysine hydrochloride has high chloride ion content, and some patients are not suitable for it. Therefore...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/18C07C227/40C07C229/26C07C51/41C07C51/42C07C53/10
CPCC07C51/412C07C51/42C07C227/18C07C227/40C07C229/26C07C53/10
Inventor 陈晓双蔡立明宁健飞
Owner WUXI JINGHAI AMINO ACID
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com