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Primary hypertension elastomer subcutaneous implant rod

An essential hypertension and flexible technology, applied in the direction of organic active ingredients, cardiovascular system diseases, medical preparations of non-active ingredients, etc., can solve the problems of human discomfort and poor effect, avoid allergens and reduce side effects , good biocompatibility effect

Inactive Publication Date: 2018-11-06
吕鹏威
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of poor effect of existing hypertension treatment methods and discomfort to human body of existing degradable materials for lowering blood pressure, the present invention provides a polymer prepared by modifying polycaprolactone with biodegradable materials, which is added with antihypertensive drugs Implant rods are implanted into the human body by subcutaneous implantation for long-term stabilization and treatment of high blood pressure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0042] The present invention adopts the ternary copolymerization method to prepare the drug carrier for the implanted rod without adding other chemical catalyst substances, and avoids the problem of allergens caused by adding other catalyst substances in other preparation methods. A method for preparing a hypertensive elastomeric subcutaneous implant rod, comprising the following steps:

[0043] The first step, the preparation of modified polycaprolactone: first put the above-mentioned parts of polycaprolactone and polyethylene glycol into the reaction kettle, stir while heating, the heating temperature is 100~150°C, stir for 5h, When the raw materials in the reaction kettle are in a viscous state, add the above-mentioned parts of polyvinylpyrrolidone and fully stir and mix for 1 hour to obtain the modified polycaprolactone;

[0044] The second step, the preparation of the implant rod: add the above-mentioned parts of enalapril, lacidipine, and irbesartan to the modified polyc...

Embodiment 1

[0046] The formula of this embodiment can produce the diameter of implant rod is 3mm, and length is 50mm, and the weight of each implant rod is 0.4g, and each implant rod contains raw material medicine is 0.13g.

[0047] Specifically, an elastomeric subcutaneous implant rod for essential hypertension, the formula of which is: polycaprolactone 200g, 400 molecular weight polyethylene glycol 150g, polyvinylpyrrolidone 20g, enalapril 50g, Cidipine 50g, irbesartan 80g, total weight 550g, each 0.4g, about 1375 made.

[0048] The preparation process of the above-mentioned implanted rods is as follows: Weigh the raw materials and wait for use; first, put polycaprolactone and polyethylene glycol into the reaction kettle, stir at 140°C for 5 hours, and the raw materials in the reaction kettle will be in a viscous state. Add polyvinylpyrrolidone and continue stirring for 1 h to prepare modified polycaprolactone. When the modified polycaprolactone is cooled to 100°C, then add enalapril, ...

Embodiment 2

[0050] The formula of this embodiment can produce implanting rods with a diameter of 3mm and a length of 25mm, each implanting rod has a weight of 0.2g, and each implanting rod contains 0.074g of raw material medicine.

[0051] Wherein, the specific formula of this embodiment is: polycaprolactone 100g, polyethylene glycol 70g, polyvinylpyrrolidone 15g, enalapril 30g, lacidipine 30g, irbesartan 48g, total weight 293g, each 0.2g, made into about 1465 sticks.

[0052]The preparation method of this embodiment is the same as that of Example 1.

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Abstract

The invention provides a primary hypertension elastomer subcutaneous implant rod. The primary hypertension elastomer subcutaneous implant rod comprises, by weight, 100 to 200 parts of polycaprolactone, 70 to 200 parts of polyethylene glycol, 15 to 20 parts of polyvinylpyrrolidone, and 100 to 180 parts of bulk drug. The bulk drug is composed of enalapril, lacidipine, and irbesartan at a mass ratioof 1:1:1.6. The degradation time of the primary hypertension elastomer subcutaneous implant rod is long; drug effect lasts long; clinical treatment of hypertension can be realized; side effect causedby long term of eating of drugs is reduced; risk caused by missed doses of drugs is avoided; and the primary hypertension elastomer subcutaneous implant rod is mainly used for clinical treatment of primary hypertension.

Description

technical field [0001] The invention relates to a subcutaneous slow-release drug implant rod. After the implant rod is implanted subcutaneously, according to the pharmacological properties of the drug mixed in the implant rod, it can treat corresponding diseases. The blood pressure elastomer subcutaneous implant rod is used for the treatment of essential hypertension. Background technique [0002] At present, the treatment of essential hypertension at home and abroad mostly relies on oral antihypertensive drugs to maintain normal blood pressure. This method of oral medicine has a short action time and requires one to three meals a day. Oral a large number of antihypertensive drugs have great side effects, cause systemic and gastrointestinal reactions, and cause great damage to liver and kidney functions. [0003] The inventor's patent CN 104147606 B discloses a biodegradable subcutaneous implant stick for long-term antihypertensive treatment, which is a kind of biodegradab...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K9/00A61K31/40A61K31/4422A61K31/4184A61P9/12
CPCA61K9/0024A61K31/40A61K31/4184A61K31/4422A61K47/34A61P9/12A61K2300/00
Inventor 吕汇川罗玉梅朱国光
Owner 吕鹏威
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