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Tissue occlusion material, method for preparing same and occlusion product

A plugging material and tissue technology, applied in medical science, surgery, ligation, etc., can solve the problems that the hemostatic speed and hemostatic volume cannot meet the requirements of emergency treatment, the liquid leakage cannot be stopped quickly, and the bursting strength is low. Excellent adhesion performance, good biocompatibility, rapid degradation and absorption effect

Active Publication Date: 2018-11-06
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Based on the above-mentioned technical problems in the prior art, for example: the adhesion is poor, and it is easy to fall off from the wound; the temperature around the wound is raised to cause a burn wound, which is difficult to heal; the speed of hemostasis and the amount of hemostasis are still not enough for a large number of rapid bleeding Emergency treatment requirements; liquid leakage cannot be stopped quickly; bursting strength is low, etc.

Method used

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  • Tissue occlusion material, method for preparing same and occlusion product

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no. 1 approach

[0043] like figure 1 As shown, in the first embodiment of the present invention, a tissue plugging material is provided, including: a matrix 1, which is formed by interweaving fibers with a diameter of 10 nm-100 μm, and at least partially has a porous structure; and A wet-state adhesive layer on at least one surface of the substrate, the wet-state adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution.

[0044] The bursting strength of the tissue plugging material of the present invention is between 0.01Kpa-60Kpa, for example: it can be 0.1Kpa-60Kpa, it can also be 1Kpa-50Kpa, it can also be 10Kpa-40Kpa, it can also be 20Kpa-30Kpa; The elongation at break of the inventive tissue plugging material is between 0.1%-500%, can be 1%-500%, can also be 10%-400%, can also be 50%-300%, can also be 100% %-200%.

[0045] The tissue plugging material of the present invention has excellent tissue adhesion performance, good water absorpti...

no. 2 approach

[0067] In the second embodiment of the present invention, a method for preparing a tissue plugging material is provided, including the step of composite molding the base body and the wet-state adhesive layer, wherein,

[0068] The matrix is ​​formed by interweaving fiber filaments with a diameter of 10nm-100μm, and at least partially has a porous structure;

[0069] The wet adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution;

[0070] The adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer.

[0071] In the present invention, the substrate may be ready-made, or the pre-prepared finished substrate may be directly compounded with the wet adhesive layer.

[0072] In the present invention, the preparation method of the matrix includes: spinning the matrix solution by using a spinning process, and then performing cross-linking treatment. The solute of the matrix solution c...

no. 3 approach

[0090] In the third embodiment of the present invention, a plugging product is provided, including the tissue plugging material according to the first embodiment, or the tissue plugging material obtained according to the preparation method of the tissue plugging material according to the second embodiment.

[0091] In the occlusive article of the present invention, optionally, there is a backing layer on the side of the substrate that does not have a wet-state adhesive layer, and a peelable layer on the wet-state adhesive layer. In the present invention, the purpose of setting the peelable layer may be to keep the wet adhesive layer with a certain humidity and not be affected by other substances. The present invention does not specifically limit the materials of the backing layer and the peelable layer, as long as they do not affect the function of the plugging product of the present application.

[0092] The occlusion product of the present invention can be used for hemostasi...

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Abstract

The invention provides a tissue occlusion material, a method for preparing the same and an occlusion product. The tissue occlusion material comprises a matrix and wet-state adhesion layers. Cellosilkwith the diameters ranging from 10 nm to 100 micrometers is interwoven to form the matrix, and the matrix is at least partially provided with porous structures; the wet-state adhesion layers are arranged on at least one surface of the matrix, the surfaces of the matrix are in contact with adhesion solution to form the wet-state adhesion layers, the adhesion solution comprises amino compounds and buffer solution, and the amino compounds are dissolved in the buffer solution. The tissue occlusion material, the method and the occlusion product have the advantages that the tissue occlusion materialis excellent in adhesion property and burst strength and appropriate in elongation at break, and can be effectively adhered with the surfaces of organisms or the surfaces of solid organs; the tissueocclusion material is further provided with porous network micro-structures formed by the cellosilk, and accordingly wound healing and tissue regeneration can be promoted.

Description

technical field [0001] The invention relates to a tissue plugging material, a preparation method thereof and a plugging product, belonging to the field of medical implant materials. Background technique [0002] Tissue closure, such as: hemostasis closure, interstitial fluid leakage closure, etc., is an important link in the operation of various departments in the hospital, and plays a considerable role in the success of the operation and the safety of the patient. Effective hemostasis is the key to relieving patients' suffering and reducing mortality, and rapid and effective hemostasis has become the focus of solving this problem. In daily life, it is inevitable to encounter damage to body tissues caused by various unexpected accidents and disasters. [0003] At present, common hemostatic materials include microporous inorganic materials (zeolites), microporous starch, fibrin glue, gelatin sponge, carboxymethylcellulose soluble hemostatic gauze, α-cyanoacrylate tissue glue...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/12
CPCA61B17/1204A61B17/12181A61B2017/12004
Inventor 李林静邓坤学袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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