Tissue occlusion material, method for preparing same and occlusion product
A plugging material and tissue technology, applied in medical science, surgery, ligation, etc., can solve the problems that the hemostatic speed and hemostatic volume cannot meet the requirements of emergency treatment, the liquid leakage cannot be stopped quickly, and the bursting strength is low. Excellent adhesion performance, good biocompatibility, rapid degradation and absorption effect
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no. 1 approach
[0043] like figure 1 As shown, in the first embodiment of the present invention, a tissue plugging material is provided, including: a matrix 1, which is formed by interweaving fibers with a diameter of 10 nm-100 μm, and at least partially has a porous structure; and A wet-state adhesive layer on at least one surface of the substrate, the wet-state adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution.
[0044] The bursting strength of the tissue plugging material of the present invention is between 0.01Kpa-60Kpa, for example: it can be 0.1Kpa-60Kpa, it can also be 1Kpa-50Kpa, it can also be 10Kpa-40Kpa, it can also be 20Kpa-30Kpa; The elongation at break of the inventive tissue plugging material is between 0.1%-500%, can be 1%-500%, can also be 10%-400%, can also be 50%-300%, can also be 100% %-200%.
[0045] The tissue plugging material of the present invention has excellent tissue adhesion performance, good water absorpti...
no. 2 approach
[0067] In the second embodiment of the present invention, a method for preparing a tissue plugging material is provided, including the step of composite molding the base body and the wet-state adhesive layer, wherein,
[0068] The matrix is formed by interweaving fiber filaments with a diameter of 10nm-100μm, and at least partially has a porous structure;
[0069] The wet adhesive layer is obtained by contacting at least one surface of the substrate with an adhesive solution;
[0070] The adhesion solution contains an amino compound and a buffer, and the amino compound is dissolved in the buffer.
[0071] In the present invention, the substrate may be ready-made, or the pre-prepared finished substrate may be directly compounded with the wet adhesive layer.
[0072] In the present invention, the preparation method of the matrix includes: spinning the matrix solution by using a spinning process, and then performing cross-linking treatment. The solute of the matrix solution c...
no. 3 approach
[0090] In the third embodiment of the present invention, a plugging product is provided, including the tissue plugging material according to the first embodiment, or the tissue plugging material obtained according to the preparation method of the tissue plugging material according to the second embodiment.
[0091] In the occlusive article of the present invention, optionally, there is a backing layer on the side of the substrate that does not have a wet-state adhesive layer, and a peelable layer on the wet-state adhesive layer. In the present invention, the purpose of setting the peelable layer may be to keep the wet adhesive layer with a certain humidity and not be affected by other substances. The present invention does not specifically limit the materials of the backing layer and the peelable layer, as long as they do not affect the function of the plugging product of the present application.
[0092] The occlusion product of the present invention can be used for hemostasi...
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