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Self-adhesive microneedle patch capable of swelling rapidly and preparation method thereof

A microneedle patch and self-adhesive technology, applied in the direction of microneedles, needles, pharmaceutical formulations, etc., can solve problems such as allergic reactions, residues in the skin, and easy breakage, and achieve reduced time and good biocompatibility Effect

Active Publication Date: 2018-11-06
深圳市上善若水创业管理合伙企业(有限合伙)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the development of the application of microneedles and microneedle patches, in addition to being widely used in transdermal delivery of drugs and vaccinations, in recent years, microneedle patches have been used to extract interstitial fluid from the skin. However, When the above-mentioned microneedle patch or the existing microneedle patch has the following problems in this application: 1. The hole of the microneedle with the traditional structure will be blocked by skin tissue; 2. It is easy to break and cause the risk of internal residue in the skin; 3. After the microneedle is inserted into the skin, it needs to be fixed with adhesive plaster or adhesive tape. The adhesive plaster or adhesive tape will cause discomfort or allergic reaction to the skin; 4. The time for the microneedle to extract the interstitial fluid of the skin is too long

Method used

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  • Self-adhesive microneedle patch capable of swelling rapidly and preparation method thereof
  • Self-adhesive microneedle patch capable of swelling rapidly and preparation method thereof
  • Self-adhesive microneedle patch capable of swelling rapidly and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Dissolving hyaluronic acid in deionized water to form a hydrophilic polymer solution with a concentration of 20 mg / mL, and then adding methacrylic anhydride to the above solution for esterification to obtain mixture A; wherein the reaction conditions are: pH=8, the temperature is 4 degrees, the time is 24h; the stirring speed is 300rpm; the molar ratio of methacrylic anhydride to hyaluronic acid is 2:1;

[0027] (2) Extraction of the esterified hydrophilic polymer in the mixture A: first add ethanol to the mixture A for precipitation to obtain a precipitate, then use water to dissolve the precipitate, and then put it into a renewable fiber dialysis bag Carry out dialysis in deionized water for 5 days, and finally take out the regenerated fiber dialysis bag and freeze-dry to obtain the esterified hydrophilic polymer; wherein, the freeze-drying conditions are: temperature: -60 degrees, pressure: 1pa;

[0028](3) Dissolve the esterified hydrophilic polymer in deionized...

Embodiment 2

[0031] (1) Dissolving collagen in deionized water to form a hydrophilic polymer solution with a concentration of 50 mg / mL, then adding methacrylic anhydride to the above solution for esterification to obtain mixture A; wherein the reaction conditions are: pH= 9. The temperature is 10 degrees, the time is 36h; the stirring speed is 1000rpm; the molar ratio of methacrylic anhydride to collagen is 50:1;

[0032] (2) Extraction of the esterified hydrophilic polymer in the mixture A: first add ethanol to the mixture A for precipitation to obtain a precipitate, then use water to dissolve the precipitate, and then put it into a renewable fiber dialysis bag Carry out dialysis in deionized water for 3 days, and finally take out the regenerated fiber dialysis bag and freeze-dry to obtain the esterified hydrophilic polymer; wherein, the freeze-drying conditions are: temperature: -60 degrees, pressure: 10pa;

[0033] (3) Dissolve the esterified hydrophilic polymer in deionized water at a ...

Embodiment 3

[0036] (1) Dissolve alginic acid in deionized water to form a hydrophilic polymer solution with a concentration of 80 mg / mL, then add methacrylic anhydride to the above solution for esterification to obtain mixture A; wherein, the reaction conditions are: pH =8, the temperature is 10 degrees, the time is 30h; the stirring speed is 5000rpm; the molar ratio of methacrylic anhydride to alginic acid is 60:1;

[0037] (2) Extraction of the esterified hydrophilic polymer in the mixture A: first add methanol to the mixture A for precipitation to obtain a precipitate, then use deionized water to dissolve the precipitate, and then put it into a renewable fiber dialysis bag Dialyze in deionized water for 7 days, and finally take out the regenerated fiber dialysis bag and freeze-dry to obtain the esterified hydrophilic polymer; wherein, the freeze-drying conditions are: temperature: -60 degrees, pressure: 5pa;

[0038] (3) Dissolve the esterified hydrophilic polymer in PBS buffer at a co...

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Abstract

The invention relates to a self-adhesive microneedle patch capable of swelling rapidly and a preparation method thereof. The self-adhesive microneedle patch and the preparation method thereof have theadvantages that first modifying agents (mixtures of one or more of acrylic anhydride and methacrylic acid) are used for modifying hydrophilic polymers to composite acrylate composite hydrophilic polymers; a secondary reaction between catechol-type compounds and the acrylate composite hydrophilic polymers is completed to composite catechol modified acrylate composite hydrophilic polymers with highbiocompatibility; when the hydrophilic polymers are prepared into the microneedle patch, the microneedle patch has high biocompatibility; the microneedle patch can absorb liquid quickly to swell, andis not blocked by skin tissues during absorption; due to the action of catechol groups, the microneedle patch can be adhered to the skin surface, additional adhesive plasters or tapes are not neededfor fixation, and accordingly, time, labor and cost are saved.

Description

technical field [0001] The invention relates to the technical fields of chemistry, material science, biomedical equipment and supplies, in particular to a rapidly swellable self-adhesive microneedle patch and a preparation method thereof. Background technique [0002] Microneedle devices, which are increasingly used in medical practice, utilize multiple microneedles passing through the stratum corneum of the skin, which is the main barrier layer for transdermal drug delivery, to form many channels through the epidermis at one time. Through the above-mentioned channels, a sufficient amount of drugs can reach the epidermis or dermis, and then the drugs are absorbed through blood vessels and lymph glands, thereby being introduced into the circulatory system of the human body. As a further application, the plurality of microneedles described above are also used for cosmetic purposes. Although the above-mentioned transdermal delivery method of effective substances using a plural...

Claims

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Application Information

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IPC IPC(8): A61B10/00A61M37/00
CPCA61M37/0015A61B10/0045A61M2037/0053A61K9/0021A61B10/0035
Inventor 徐臣杰陈鹏常皓
Owner 深圳市上善若水创业管理合伙企业(有限合伙)
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