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Povidone-iodine solution and preparation method thereof

A technology of povidone iodine and solution, which is applied in the direction of medical formulations, active ingredients of iodine compounds, medical preparations of non-active ingredients, etc., which can solve the problem of easily taking away skin heat and moisture, loss of elasticity of cow nipple skin, and affecting medicated bath Function and other issues, to achieve the effect of eliminating the invasion of germs and microorganisms, saving labor and drug costs, and having no toxic and side effects

Active Publication Date: 2021-04-27
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the dairy cow medicated baths currently on the market have a high water content, which makes the medicated bath drip after infiltrating the cow’s teats, does not adhere to the cow’s teats, or is easily rubbed off by the cow’s bed, which greatly affects the effect of the post-medication bath and causes waste of medication.
[0003] It can be seen from the article "Development and Application Effect Observation of Cow Nipple Liquid Protective Film" published by Zhou Qingmin, Heilongjiang Veterinary Science Research Institute, etc., that although its prescription can be made into a film-forming povidone-iodine solution, it uses Azone, ethanol and other organic solvents are used as volatile agents. Ethanol is volatile and easily takes away part of the heat and moisture from the skin, resulting in dry skin and affecting the protective effect; at the same time, ethanol has super penetrating power, which can penetrate into the cell body and cause dehydration , long-term use will make the skin of the cow’s nipple gradually lose its elasticity, and the medicated bath liquid containing ethanol is not suitable for use in the lactation period of the cow, and it is easy to remain in the milk, affecting the quality of the milk, and even alcohol-positive milk

Method used

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  • Povidone-iodine solution and preparation method thereof
  • Povidone-iodine solution and preparation method thereof
  • Povidone-iodine solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0034] A kind of povidone-iodine solution, by every 100g solution, its raw material composition sees the following table 1.

[0035] The formula table of table 1 embodiment 1~3

[0036] Raw materials (unit g) Example 1 Example 2 Example 3 potassium iodate 0.036 0.18 0.36 potassium iodide 0.32 1.6 3.2 dodecyl dimethyl amine oxide 0.5 1 1.5 pvp 1 1 1 PVA 2 2 2 Polyurethane 35 5 5 5 sodium alginate 0.5 0.5 0.4 Propylene Glycol 2 2 2 citric acid 0.2 0.2 0.2 Sodium citrate 0.4 0.4 0.4 water margin margin margin

[0037] Its preparation method is as follows:

[0038] 1. Put water into the preparation tank, start the stirring device, put citric acid and film-forming agents PVP, PVA, polyurethane 35, and sodium alginate in sequence, start steam heating, raise the temperature to 80°C to 90°C, and stir for 2 ~3 hours, mix well.

[0039] 2. Put the plasticizer propylene glycol ...

Embodiment 4

[0043] Example 4 is basically the same as Example 2, except that the surfactant used is different, specifically, 1 g of fatty alcohol polyoxyethylene ether is used instead of 1 g of dodecyldimethylamine oxide.

Embodiment 5

[0045] Example 5 is basically the same as Example 1, except that the plasticizer used is different, specifically, 2 g of phthalates are used instead of 2 g of propylene glycol.

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Abstract

The invention relates to a povidone-iodine solution and a preparation method thereof. Wherein, the povidone-iodine solution per 100g is mainly prepared from the following raw materials by weight: potassium iodate 0.02g-0.5g, potassium iodide 0.1g-3.5g, PVP 0.5g-5g, polyvinyl alcohol 1g-5g, 2g-10g of polyurethane, 0.1g-5g of sodium alginate, 0.2g-0.5g of organic acid, 0.5g-3.5g of surfactant, 1g-5g of plasticizer, and the balance is water and pH regulator. The povidone-iodine solution is safe and reliable, has good stability, and has good film-forming effect. The formed film has high toughness and is not easy to fall off. The drug effect is long-lasting. While ensuring the antibacterial effect, it can also save a lot of labor and drug costs, and is suitable for the majority of dairy cows. field.

Description

technical field [0001] The invention relates to the technical field of veterinary disinfectants, in particular to a povidone-iodine solution and a preparation method thereof. Background technique [0002] In the dairy farming industry, dairy cow mastitis has always been a problem for dairy farmers, and it is also one of the main causes of economic losses for dairy farmers. Every time before and after milking, the nipples of cows should be disinfected to prevent and control the occurrence of mastitis in cows, especially after dipping plays an important role in preventing mastitis in cows. Most of the dairy cow medicated baths currently available in the market have a high water content, which makes the medicated bath drip after infiltrating the cow's teats, does not adhere to the cow's teats, or is easily rubbed off by the cow's bed, which greatly affects the effect of the post-medication bath and causes waste of medication . [0003] It can be seen from the article "Develop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K33/18A61K31/79A61K47/32A61K47/34A61K47/36A61K47/12A61K47/10A61P15/14A61P31/02A61P31/04
CPCA61K9/0041A61K9/08A61K31/79A61K33/18A61K47/10A61K47/12A61K47/32A61K47/34A61K47/36A61P15/14A61P31/02A61P31/04A61K2300/00
Inventor 徐奇清周淑贞张庆黄海青聂姣
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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