LC/MS method for the simultaneous determination of 45 prohibited drugs in health food for the three high populations

A technology for health food and people, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of illegally adding chemicals, easy to illegally add chemicals without income, etc., to achieve a wide range of applications, large detection capacity, good application Foreground effect

Inactive Publication Date: 2020-12-29
ZHEJIANG INST FOR FOOD & DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some criminals with high IQ who are familiar with pharmacology and drug effects illegally add chemicals across indications in order to evade relevant laws and regulations
For example, metformin, glibenclamide and other clinical first-line hypoglycemic prescription drugs that are mainly used

Method used

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  • LC/MS method for the simultaneous determination of 45 prohibited drugs in health food for the three high populations
  • LC/MS method for the simultaneous determination of 45 prohibited drugs in health food for the three high populations
  • LC/MS method for the simultaneous determination of 45 prohibited drugs in health food for the three high populations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0118] Apparatus and reagent used in the present invention are as follows:

[0119] instrument:

[0120] 1290 type ultra-high performance liquid chromatography (Agilent), G6460 triple quadrupole mass spectrometer (Agilent), Agilent Eclipse Plus C18 column (100mm × 2.1mm, 5 μm; filler: octadecylsilane bonded silica gel; Agilent), Elmasonic P300H ultrasonic cleaner (Elma), Delta 320pH meter (Mettler-Toledo), XPE 205 analytical balance (Mettler-Toledo), Genpure UV / UF ultrapure water Instrument (Thermo Fisher Scientific Company), Multifuge X1 high-speed centrifuge (Thermo Fisherman Scientific Company).

[0121] Test drug:

[0122] Glibenclamide (batch number 100135-200404, 100%), metformin hydrochloride (batch number 100664-201203, 100.0%), rosiglitazone maleate (batch number 100952-200701, 99.5%), phenformin hydrochloride ( 201001, 99.7%), Gliclazide (100269-200603, 99.9%), Glipizide (100281-200602, 99.4%), Tolbutamide (100500-200801, 100.0%), Glimepiride ( 100674-201102, 99....

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Abstract

The invention particularly relates to a high performance liquid chromatography-mass spectrometry combined method for simultaneously detecting 45 types of banned drugs in health-care food for people groups with three highs (high hypertension, hyperlipemia and hyperglycemia), and belongs to the technical field of detection of chemical drugs illegally added into health-care products. According to themethod, 5mmol.L<-1> of ammonium acetate liquor and acetonitrile are subjected to gradient elution on an Agilent Eclipse Plus C18 column, wherein the flow speed is 0.2mL.min<-1>; samples are ionized in the mode of positive and negative ions of electric-spray ion sources through mass spectrometry, and a multi-reaction monitor mode is applied to detection of the 45 types of chemical drugs. Three batches of positive samples from 300 batches of samples are detected in total, and detected drugs are phenformin, glibenclamide, hydrochlorothiazide and amlodipine. The high performance liquid chromatography-mass spectrometry combined method has the advantages that detection volume is high, neglected detection of the banned drugs can be avoided to a certain extent, and the method has a wide application range and a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of determination of illegally added chemicals in health care products, and in particular relates to a liquid chromatography-mass spectrometry method capable of simultaneously determining 45 kinds of prohibited drugs in health care food for three high populations. Background technique [0002] Hyperglycemia, hyperlipidemia, and hypertension are commonly known as the "three highs". These three constitute the main body of metabolic syndrome. At the same time, the incidence of metabolic syndrome will increase with age. On the other hand, hypertension, hyperlipidemia and hyperglycemia may exist alone or may be related to each other. For example, patients with hyperglycemia are likely to suffer from hyperlipidemia at the same time, and hyperlipidemia is the main factor in the formation and development of arteriosclerosis, which in turn leads to poor blood vessel elasticity and hypertension. Therefore, in order to...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/50G01N30/60
CPCG01N30/06G01N30/50G01N30/60
Inventor 周明昊寿林均程巧鸳胡磊颜琳琦吴鸳鸯刘晨晨张丽媛王任王欢陈岑戚绿叶严俊
Owner ZHEJIANG INST FOR FOOD & DRUG CONTROL
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