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Medical degradable corrosion resistant magnesium alloy stent implanted into heart and preparation method thereof

A magnesium alloy stent and corrosion-resistant technology, applied in the field of medical alloys, can solve problems such as vascular stenosis, vascular wall stimulation, and increased probability of vascular intimal hyperplasia, achieve excellent mechanical properties and corrosion resistance, and avoid damage to human health. Effect

Inactive Publication Date: 2018-10-19
王甲林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The non-degradable metal stent remains in the human body as a foreign body, which will stimulate the blood vessel wall, significantly increase the probability of intimal hyperplasia of the blood vessel, and easily cause restenosis of the blood vessel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A medical degradable corrosion-resistant magnesium alloy stent implanted in the heart, characterized in that it consists of the following elements in mass percentage: Zn 12.5, Nd 3.6, Ca 3.2, Mn 1.1, Y 0.52, Zr 0.2, Sn 0.5, Gd 0.4, Sr 0.25, Nd / Y6.92, Gd / Zr 2, the rest are Mg and unavoidable impurity elements, the components of the unavoidable impurity elements and the weight percentage of each component are: Fe 0.002-0.005%, Ni 0.005 -0.008%, Si 0.015-0.05%.

[0043] The preparation method of the medical degradable corrosion-resistant magnesium alloy stent implanted in the heart is characterized in that:

[0044] (1) Selection of raw materials

[0045] Mg ingot with a purity of 99.99%, Zn ingot with a purity of 99.99%, Mg-Zn master alloy with a mass ratio of Zn of 53 wt%, Mg-Nd master alloy with a mass ratio of Nd of 18 wt%, Mg with a mass ratio of Gd of 25% - Gd master alloy, Y mass ratio accounts for Mg-Y master alloy, Zr mass ratio accounts for 30% Mg-Zr master all...

Embodiment 2

[0053] A medical degradable corrosion-resistant magnesium alloy stent implanted in the heart, characterized in that it consists of the following elements in mass percentage: Zn 12.6, Nd 3.65, Ca 3.3, Mn 1.15, Y 0.55, Zr 0.25, Sn 0.55, Gd 0.42, Sr 0.22, Nd / Y6.63, Gd / Zr 1.68, the rest are Mg and unavoidable impurity elements, the components of the unavoidable impurity elements and the weight percentages of each component are: Fe 0.002-0.005%, Ni 0.005 -0.008%, Si 0.015-0.05%.

[0054] The preparation method of the medical degradable corrosion-resistant magnesium alloy stent implanted in the heart is characterized in that:

[0055] (1) Selection of raw materials

[0056] Mg ingot with a purity of 99.99%, Zn ingot with a purity of 99.99%, Mg-Zn master alloy with a mass ratio of Zn of 53 wt%, Mg-Nd master alloy with a mass ratio of Nd of 18 wt%, Mg with a mass ratio of Gd of 25% - Gd master alloy, Y mass ratio accounts for Mg-Y master alloy, Zr mass ratio accounts for 30% Mg-Zr m...

Embodiment 3

[0064] A medical degradable corrosion-resistant magnesium alloy stent implanted in the heart, characterized in that it consists of the following elements in mass percentage: Zn 12.8, Nd 3.75, Ca 3.7, Mn 1.25, Y 0.75, Zr 0.35, Sn 0.65, Gd 0.48, Sr 0.28, Nd / Y5, Gd / Zr 1.37, the rest are Mg and unavoidable impurity elements, the components of the unavoidable impurity elements and the weight percentages of each component are: Fe 0.002-0.005%, Ni 0.005-0.008 %, Si 0.015-0.05%.

[0065] The preparation method of the medical degradable corrosion-resistant magnesium alloy stent implanted in the heart is characterized in that:

[0066] (1) Selection of raw materials

[0067] Mg ingot with a purity of 99.99%, Zn ingot with a purity of 99.99%, Mg-Zn master alloy with a mass ratio of Zn of 53 wt%, Mg-Nd master alloy with a mass ratio of Nd of 18 wt%, Mg with a mass ratio of Gd of 25% - Gd master alloy, Y mass ratio accounts for Mg-Y master alloy, Zr mass ratio accounts for 30% Mg-Zr mast...

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Abstract

The invention discloses a medical degradable corrosion resistant magnesium alloy stent implanted into a heart. The medical degradable corrosion resistant magnesium alloy stent implanted into a heart is characterized by comprising 12.5-13wt% of Zn, 3.6-3.8wt% of Nd, 3.2-3.8wt% of Ca, 1.1-1.3wt% of Mn, 0.5-0.8wt% of Y, 0.2-0.4wt% of Zr, 0.5-0.7wt% of Sn, 0.4-0.5wt% of Gd, 0.2-0.3wt% of Sr, 4.55-7wt%of Nd / Y, 1.1-2.4wt% of Gd / Zr, the balance of Mg and inevitable impurities. The components of the inevitable impurities and the weight percents of the components are Fe 0.002-0.005%, Ni 0.005-0.008%,Si 0.015-0.05%. The particle size of Mg3Nd precipitates in microstructure is 0.10-0.15[mu]m; the particle size of Mg3Y2Zn3 precipitates is 0.15-0.20[mu]m; the particle size of Ca2Mg6Zn3 precipitates in microstructure is 0.3-0.5[mu]m; the magnesium alloy has a grain size of 50-60[mu]m, a tensile strength of 300-380 MPa, a yield strength of 180-250 MPa, and an elongation of 20-35%.

Description

technical field [0001] The invention belongs to the field of medical alloys, in particular to a medical degradable corrosion-resistant magnesium alloy stent implanted in the heart. Background technique [0002] Compared with traditional implant materials, magnesium alloys are relatively close to human bones in terms of specific strength and Young's modulus, and magnesium ions are conducive to the formation of bone cells, which not only reduces the stress between implant materials and bones The role of shielding prevents osteoporosis, and promotes the regeneration of human bones. Therefore, magnesium alloys are considered as potential implantable biomaterials. On the other hand, magnesium can be degraded in the human body, thus avoiding secondary surgery for patients, reducing the pain caused by surgery, and reducing medical expenses. Therefore, biodegradable magnesium alloys have been widely used in orthopedics, cardiovascular, general surgery and other fields. [0003] M...

Claims

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Application Information

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IPC IPC(8): C22C23/04C22C1/03C22C1/06C22F1/06A61L31/02A61L31/10A61L31/14A61L31/16
CPCA61L31/022A61L31/10A61L31/148A61L31/16C22C1/03C22C1/06C22C23/04C22F1/06C08L89/00
Inventor 王甲林
Owner 王甲林
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