Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Azaspirone drug injection, preparation method and uses thereof

A technology of spirone injection and tandospirone injection, which is applied in the field of azaspirone drug injection, can solve the problems of poor anti-anxiety effect and poor stability, and achieve the effect of low cost, high stability and good stability

Active Publication Date: 2018-10-09
SICHUAN CREDIT PHARMA
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a new type of tandospirone injection, its preparation method and use, so as to solve the problem of poor stability and poor anxiolytic effect of tandospirone pharmaceutical preparations in the prior art, so as to solve the problem of existing tandospirone Improve the stability and anti-anxiety effect of the drug, thereby providing a tandospirone injection with high stability and good anti-anxiety effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Azaspirone drug injection, preparation method and uses thereof
  • Azaspirone drug injection, preparation method and uses thereof
  • Azaspirone drug injection, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 20mg of tandospirone citrate, add appropriate amount of water for injection, stir until the solution is clear, add citric acid, and then dilute to 200mL with water for injection; add needle to absorb with activated carbon, filter to remove activated carbon, sterilize, pack That is, 100 water injections of tandospirone were obtained.

Embodiment 2

[0025] Weigh 2g of tandospirone citrate, add an appropriate amount of water for injection, stir until the solution is clear, add hydrochloric acid, and then dilute to 200mL with water for injection; add needles to absorb with activated carbon, filter to remove activated carbon, sterilize, and pack to get ready. Tandospirone water injection 100 pieces.

Embodiment 3

[0027] Weigh 4g of tandospirone citrate, add an appropriate amount of water for injection, stir until the solution is clear, add sodium hydroxide, and then dilute to 200mL with water for injection; add the needle to adsorb with activated carbon, filter to remove the activated carbon, sterilize, and pack That is, 100 water injections of tandospirone were obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an azaspirone drug injection, a preparation method and uses thereof, wherein the azaspirone drug injection contains a tandospirone active component and a stabilizer. Accordingto the present invention, the azaspirone drug injection has characteristics of high stability and good anti-anxiety effect, and can meet the needs of clinical patients; the problem that children, orpatients with digestive system disorder, or patients in coma, tic, convulsion, and other states, and patients with dysphagia (such as elderly patients and bedridden patients) are not suitable for theoral administration of tandospirone tablets or capsules can be effectively solved with the azaspirone drug injection; and the azaspirone drug injection further has advantages of low cost, convenient use and the like, wherein the solution of the azaspirone drug injection is clarified, the insoluble particles meet the standard and have good stability, the visible foreign matter does not exist, the azaspirone drug injection does not have abnormal toxicity, and the concentration of the azaspirone drug injection cannot cause toxicity and obvious irritation.

Description

technical field [0001] The invention relates to an azaspirone drug injection, a preparation method and application thereof. Background technique [0002] Anxiety is the most common emotional reaction and a central symptom of all neuroses. With the development of society and the accelerated pace of life, people's demand for anti-anxiety drugs is increasing day by day. The first-generation anti-anxiety drugs represented by meprobamate have poor drug resistance and severe withdrawal symptoms, and the second-generation anti-anxiety drugs of benzodiazepines have psychomotor dysfunction such as muscle relaxation, spasm, and spontaneous movement , memory discrimination dysfunction, psychological and physical dependence and other problems. The third-generation anti-anxiety drugs represented by tandospirone selectively act on the 5-HT1A receptors in the brain, and the action sites are concentrated in the hippocampus, amygdala and other brain limbic systems in the emotional center a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/19A61K9/08A61K47/12A61K47/02A61K47/04A61K31/506A61P25/22
CPCA61K47/02A61K47/12A61K9/0019A61K9/08A61K9/19A61K31/506
Inventor 陶建林李晓莉陈刚王平赵思江
Owner SICHUAN CREDIT PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com