Pharmaceutical compositions for improving bone loss of hyperthyroid high-conversion type and reduction of biomechanical properties of bone

Abstract

The invention provides pharmaceutical compositions for improving the bone loss of hyperthyroid high-conversion type and the reduction of the biomechanical properties of the bone, and relates to an extract of a Chinese medicinal Danshen, or the formula and the production process of pharmaceutical compositions for improving the bone loss of high-conversion type and the reduction of the biomechanicalproperties of the bone caused by the hypersplenism of the thyroid, which is prepared from the following components in parts by weight: 0.1 to 0.3 g of a danshensu and 5 g of crystalline fructose, thepharmaceutical compositions are characterized by being prepared into an injection. The invention further discloses a formula and production process of the injection, a granule and a non-alcoholic beverage. The high-dose thyroxine-induced hyperthyroid high-conversion bone loss animal model proves that the pharmaceutical composition prepared from the danshensu and the fructose can influence the bone metabolism of the rat, promote the bone formation, inhibit the bone resorption, increase the bone mass, improve the bone mineral density and the bone mineral salt content, and improve the performance of the bone biomechanics, and has a good preventive effect on the damage of the bone biological biomechanical properties of the hyperthyroid osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of health food and medicine production, and specifically relates to a formula and a production process of a group of pharmaceutical compositions for improving high-transition bone loss and bone biomechanical performance decline caused by hyperthyroidism. Background technique [0002] Hyperthyroidism refers to the general term for clinical diseases characterized by systemic hypermetabolic hyperactivity caused by elevated thyroid hormone levels in the human body, causing increased excitability of the body's nervous, circulatory, and digestive systems. It is a common organ-specific autoimmune disease in clinical practice. Thyroid disease is also a high-energy-consuming disease that consumes too much energy in the human body. Clinically, the disease often manifests as hypermetabolic syndromes such as palpitations, insomnia, irritability, and weight loss. Thyroid disease represented by hyperthyroidism has become...

AI Technical Summary

Problems solved by technology

At present, the expression of fructose-specific transporters has not been found in bone tissue, and there are few studies on the effects of fructose and glucose in monosaccharides on bone

Studies have found that compared with animals on a normal diet, a high-fructose diet has no adverse effects on bone tissue in animals, and even compared with a high-glucose diet, a high-fructose diet can improve bone microstructure and improve bone quality. Fructose metabolism and how fructose maintains a healthy state of bone tissue is not yet clear to researchers, but they all speculate that it may be related to the process of energy metabolism, and the dynamic balance of bone microenvironment is achieved by maintaining a good state of energy circulation supply

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