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Application of Ganoderma lucidum polysaccharide in preparing traditional Chinese medicine immune enhancer

An immune enhancer and Ganoderma lucidum polysaccharide technology, applied in the field of traditional Chinese medicine immune enhancer, can solve the problems of large dosage of traditional Chinese medicine, inconvenient use, difficult mixing, etc., and achieve the effect of reducing preparation cost, reducing immune enhancer dose, and improving preparation rate

Active Publication Date: 2020-06-26
NANJING AGRICULTURAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to this patent, a number of technical solutions of traditional Chinese medicine immune enhancers have also been disclosed. However, during the use of this type of technical immune enhancers, they are all added to poultry feed throughout the process, which requires daily feeding before feeding. It is necessary to add traditional Chinese medicine enhancer to the feed and mix and stir to achieve the purpose of thorough mixing. It is extremely inconvenient to use
Although the amount increased every day is small, the dosage of traditional Chinese medicine required for the whole process of breeding is still very large, and the smaller the amount, the more difficult it is to mix, and there is a serious shortage

Method used

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  • Application of Ganoderma lucidum polysaccharide in preparing traditional Chinese medicine immune enhancer
  • Application of Ganoderma lucidum polysaccharide in preparing traditional Chinese medicine immune enhancer
  • Application of Ganoderma lucidum polysaccharide in preparing traditional Chinese medicine immune enhancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of ganoderma lucidum polysaccharide is used for the purposes of preparing traditional Chinese medicine immunostimulant, and its steps are as follows:

[0027] (1) Wash the rhizomes of red Ganoderma lucidum fruiting bodies, cut them into pieces, and place them in an oven at 105°C to inactivate enzymes for 5 minutes; after inactivating enzymes, place them in an oven at 55°C to dry, crush, and pass through a 40-mesh sieve;

[0028] (2) Add 5 times the volume fraction of 95% ethanol and heat in a water bath to remove small molecule monosaccharides and fats, filter, and dry the filter residue in a cool and ventilated place, and seal it at 4°C for later use;

[0029] (3) Take 10g of dried ganoderma lucidum powder after pretreatment, then put the medicinal material powder in a 100mL round bottom flask, add distilled water at a ratio of material to liquid 1:20, extract in a constant temperature water bath at 100°C for 1 hour, filter, and repeat the operation 3 times;

[...

Embodiment 2

[0037] A kind of ganoderma lucidum polysaccharide is used for the purposes of preparing traditional Chinese medicine immunostimulant, and its steps are as follows:

[0038] (1) Wash the rhizomes of red Ganoderma lucidum fruiting bodies, cut them into pieces, and place them in an oven at 105°C to inactivate enzymes for 5 minutes; after inactivating enzymes, place them in an oven at 55°C to dry, crush, and pass through a 40-mesh sieve;

[0039] (2) Add 5 times the volume fraction of 95% ethanol and heat in a water bath to remove small molecule monosaccharides and fats, filter, and dry the filter residue in a cool and ventilated place, and seal it at 4°C for later use;

[0040] (3) Take 10g of dried ganoderma lucidum powder after pretreatment, then put the medicinal material powder in a 100mL round bottom flask, add distilled water at a ratio of material to liquid 1:20, extract in a constant temperature water bath at 100°C for 1 hour, filter, and repeat the operation 3 times;

[...

Embodiment 3

[0048] A kind of ganoderma lucidum polysaccharide is used for the purposes of preparing traditional Chinese medicine immunostimulant, and its steps are as follows:

[0049] (1) Wash the rhizomes of red Ganoderma lucidum fruiting bodies, cut them into pieces, and place them in an oven at 105°C to inactivate enzymes for 5 minutes; after inactivating enzymes, place them in an oven at 55°C to dry, crush, and pass through a 40-mesh sieve;

[0050] (2) Add 5 times the volume fraction of 95% ethanol and heat in a water bath to remove small molecule monosaccharides and fats, filter, and dry the filter residue in a cool and ventilated place, and seal it at 4°C for later use;

[0051] (3) Take 10g of dried ganoderma lucidum powder after pretreatment, then put the medicinal material powder in a 100mL round bottom flask, add distilled water at a ratio of material to liquid 1:20, extract in a constant temperature water bath at 100°C for 1 hour, filter, and repeat the operation 3 times;

[...

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Abstract

The invention provides a preparation and use method of a ganoderan Chinese medicine immunoenhancer. Polysaccharides in ganoderma lucidum sporocarp materials are extracted to prepare the Chinese medicine immunoenhancer, Newcastle disease IV nasal drip and eye droppings are used for 14-day-old non-immune chicken to realize primary immunization, secondary immunization is performed when the chicken are 28 days old, the chicken are orally drenched with ganoderan solution in each time of immunization, administration dosage is 12.5-50mg / kg of the body weight, and administration is performed once a day and continuously performed for three days. Measurement is performed in the 7th day, the 14th day, the 21st day and the 28th day of primary immunization and finds that ganoderan can obviously promoteperipheral blood and splenic lymphocytes proliferation of the chicken, ND-HI antibody level is improved, immune organ index is improved, the concentration of cell factors such as IL-4, IL-6 and IFN-gin serum is improved, the SIgA content of duodenums is increased, so that body immunity is improved, and the immune effect of vaccines is enhanced.

Description

technical field [0001] The invention belongs to the field of immune enhancers, in particular to a traditional Chinese medicine immune enhancer used for poultry and livestock. Background technique [0002] Infectious diseases of livestock and poultry, especially viral diseases, are the primary problem that endangers the development of animal husbandry, and also bring huge losses to the livestock and poultry breeding industry. Due to the unique biological characteristics and pathogenesis of viruses, there is currently no effective treatment for viral diseases, so vaccination has become the main preventive measure. However, due to various reasons, clinical immune failure often occurs. In order to improve the body's specific response to antigens or microorganisms and enable the body to obtain better immune protection, immune enhancers have emerged as the times require. Immunopotentiators are a class of substances that increase the body's specific response to antigens or microo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K39/17A61P37/04A61P31/14
CPCA61K31/715A61K39/12A61K2039/543A61K2039/552A61P31/14A61P37/04C12N2760/18134A61K2300/00
Inventor 张萍江善祥李艳艳徐孝宙刘海侠戴鼎震蒋加进杨海峰
Owner NANJING AGRICULTURAL UNIVERSITY
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