Composition for treating skin immune diseases as well as preparation method thereof
A technology of immune diseases and compositions, applied in the field of medicine, can solve problems such as many adverse reactions of systemic treatment, difficulties in psoriasis treatment, physical and mental impact of patients, etc., achieve efficient, simple and controllable preparation process, and good retention of skin targeting , the effect of convenient administration
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Embodiment 1
[0036] Embodiment 1 A kind of composition for the treatment of skin immune disease
[0037] The present embodiment composition comprises the following raw materials by mass percentage:
[0038]
[0039] The preparation method of this embodiment composition:
[0040] A. According to the formula ratio, at room temperature, menthol and camphor are ground to form a transparent and clear solution;
[0041] B. According to the formula ratio, add tacrolimus into Transcutol P, and stir until the drug is completely dissolved;
[0042] C. According to the formula ratio, at room temperature, add the transparent and clear solution in step A and Cremophor EL to the solution described in step B sequentially under stirring until uniform and stable concentrated milk is formed;
[0043] D. According to the formula ratio, slowly add water into the solution described in step C, and keep stirring until it is transparent and clear.
Embodiment 2
[0044] Embodiment 2 A kind of compound gel for the treatment of skin immune disease
[0045] First by following charge ratio and with the preparation method identical with embodiment 1, make composition:
[0046]
[0047] Then add the composition to 0.5% carbomer aqueous solution containing propylene glycol and benzyl alcohol, the concentration of the composition is 10%, mix well, then add triethanolamine to adjust the pH to 4.5-5.5, stir until transparent and uniform gel form.
[0048]Therefore, the final prescription of the compound gel for the treatment of skin immune diseases in this embodiment is:
[0049]
[0050] Next, the composition and compound gel for treating skin immune diseases prepared by the present invention are further tested for their effects.
[0051] 1. Transdermal detection experiment
[0052] The above-mentioned composition for treating immune diseases of the skin (hereinafter referred to as the composition), the compound gel (hereinafter referr...
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