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Ion-mediated dressing and its preparation method and application

An ionic, mediated technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as non-antibacterial, hemostasis wound healing, limited hydrogel application, granulation tissue adhesion to scabs, etc.

Active Publication Date: 2021-05-11
NANKAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although traditional dressings have a protective effect on wounds, there are many shortcomings as follows: (1) they do not have moisturizing effect and cannot provide a moist environment; (2) they do not have the functions of antibacterial, hemostasis, and wound healing; (3) they are easy to adhere to wound tissue , the granulation tissue is easy to grow into the gauze mesh to cause adhesion and scab, and it is easy to cause secondary damage when evacuating
Traditional hydrogels have poor mechanical properties, which greatly limits the application of hydrogels

Method used

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  • Ion-mediated dressing and its preparation method and application
  • Ion-mediated dressing and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: A method for preparing an ion-mediated multifunctional skin dressing, using gauze as the base material and cobalt ion concentration of 0.25g / L to prepare a cobalt ion-mediated multifunctional skin dressing, which was applied to mice The skin damage repair of the full-thickness skin defect infection model, the specific steps are as follows:

[0025] 1. Preparation of cobalt ion-mediated multifunctional skin dressing

[0026] (1) Cut the gauze into discs with a diameter of 1cm (each disc contains 2 layers of gauze)

[0027] (2) Prepare 0.25g / LCo 2+ solution and 4g / LCa 2+ Solution, 0.25g / LCo 2+ solution and 4g / LCa 2 +The solution is mixed according to the ratio of 1:1

[0028] (3) Soak the round piece of gauze cut in each step (1) in 100 μL (that is, the ratio of the area of ​​the substrate to the volume of the soaking solution is 0.785m 2 / L) in the mixed solution in step (2), dry.

[0029] (4) Prepare 1wt% sodium alginate, and evenly drop every 100 μL o...

Embodiment 2

[0036] The preparation method of embodiment 2 is the same as that of embodiment 1, the only difference is that the substrate in step 1.1 is a non-woven fabric; in step 1.2, the Ca 2+ The concentration of the ion solution is 0.1g / L, Co 2+ The concentration of the ion solution is 20g / L; the Ca 2+ :Co 2+ =1:200. In step 1.3, the ratio of the substrate area to the volume of the soaking solution is 0.001m 2 / L; In step 2, it was applied to the skin injury repair of the full-thickness skin defect infection model in rats. The experimental results show that the application of the ion-mediated multifunctional skin dressing reduces the amount of bacteria in the skin wound of rats, the healing area is larger, and the healing effect is better.

Embodiment 3

[0038] The preparation method of embodiment 3 is the same as that of embodiment 1, the only difference is that in step 1.2, the Ca 2+ The concentration of the ion solution is 200g / L, Co 2+ The concentration of the ionic solution is 0.01g / L; the Ca 2+ :Co 2+ =20000:1. In step 1.3, the ratio of substrate area to soaking liquid volume is 5m 2 / L.

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Abstract

The invention belongs to the field of medical devices, and in particular relates to an ion-mediated dressing and its preparation method and application. The ion-mediated dressing includes a hydrogel prepared by sodium alginate, a substrate for supporting the hydrogel, and Ca adsorbed on the substrate. 2+ 、Co 2+ ion. The dressing prepared by the present invention is prepared by immersing the base material in Co 2+ and Ca 2+ The mixed solution can make the ions evenly distributed on the substrate, thus solving the problem of uneven gelation of the hydrogel in the traditional method, which is beneficial to Co 2+ and Ca 2+ uniform sustained release. The dressing prepared by the present invention passes Co 2+ and Ca 2+ Jointly participate in the gelation process of hydrogels, due to Co 2+ Can mediate hypoxia-induced response to stimulate angiogenesis and promote skin repair, antibacterial, Ca 2+ It can promote the formation of prothrombin activators and is beneficial to hemostasis, so the dressing prepared by the invention has the functions of antibacterial, hemostasis and promoting skin damage repair.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to an ion-mediated dressing and its preparation method and application. Background technique [0002] Skin is the largest organ in the human body. As the most critical physical barrier between the human body and the environment, the skin undertakes many important physiological functions to maintain the normal operation of the human body. The skin has two barrier functions: on the one hand, it prevents the loss of water, electrolytes, and other substances in the body; on the other hand, it prevents the intrusion of harmful substances from the outside. However, the skin is the first line of defense of the human body. When trauma occurs, skin damage is very common. Skin injury has become a major health problem worldwide, especially chronic wounds such as diabetic ulcers, which not only cause great pain to patients, but also expose patients to the risk of severe infection an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/46
CPCA61L15/18A61L15/28A61L15/42A61L15/46A61L2400/04C08L5/04
Inventor 王恺孔德领师庆英张钧罗鑫智登科
Owner NANKAI UNIV
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