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Meso-porous hydroxyapatite ceramic percutaneous implanting pathway device and preparation method thereof

A hydroxyapatite and nano-hydroxyapatite technology, applied in ceramic products, ceramic molding machines, manufacturing tools, etc., can solve the problems of material falling off and cannot exist for a long time, and achieve good biocompatibility and excellent mechanical properties. , the effect of wide application prospects

Inactive Publication Date: 2018-08-17
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these materials are used as transdermal components, there are very serious problems, such as bacterial infection and epithelial descending, which will form a gap between the material and the skin tissue, which will cause the material to fall off from the body and cannot exist for a long time

Method used

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  • Meso-porous hydroxyapatite ceramic percutaneous implanting pathway device and preparation method thereof
  • Meso-porous hydroxyapatite ceramic percutaneous implanting pathway device and preparation method thereof
  • Meso-porous hydroxyapatite ceramic percutaneous implanting pathway device and preparation method thereof

Examples

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Effect test

Embodiment 1

[0025] A method for preparing a mesoporous hydroxyapatite ceramic percutaneously implanted access device, comprising the following steps: (1) heating 20ml of deionized water to 90°C to maintain a constant temperature, then weighing 0.4g of polyvinyl alcohol and adding in three times In water and constantly stirring, until polyvinyl alcohol dissolves completely, obtain the polyvinyl alcohol solution that mass fraction is 2%; (2) accurately weigh 10g hydroxyapatite powder and 0.4g nanometer carbon powder, carbon powder is mixed with hydroxyl Mix the apatite powder evenly, then add 2ml vinyl alcohol solution dropwise to the mixed powder, stir while dripping, and then perform ball milling to make it fully mixed to obtain a wet powder; (3) Put the wet powder into the mold three times Carry out calendering into sheets, the pressure is 5MPa, keep the pressure for 5min, get the preliminary green body, then put the green body into the rubber glove to extract the vacuum and seal it, and ...

Embodiment 2

[0027] A method for preparing a mesoporous hydroxyapatite ceramic percutaneously implanted access device, comprising the following steps: (1) heating 20ml of deionized water to 90°C to maintain a constant temperature, then weighing 1g of polyvinyl alcohol and adding it to the water three times And constantly stir, until polyvinyl alcohol dissolves completely, obtain the polyvinyl alcohol solution that mass fraction is 5%; (2) accurately weigh 10g hydroxyapatite powder and 0.4g nano carbon powder, carbon powder is mixed with hydroxyphosphorus earlier Mix the limestone powder evenly, then add 2ml of polyvinyl alcohol solution dropwise to the mixed powder, stir while dripping, and then perform ball milling to make it fully mixed to obtain a wet powder; (3) Put the wet powder into the mold three times Carry out calendering into sheets, the pressure is 5MPa, keep the pressure for 5min, get the preliminary green body, then put the green body into the rubber glove to extract the vacuu...

Embodiment 3

[0029]A method for preparing a mesoporous hydroxyapatite ceramic percutaneously implanted access device, comprising the following steps: (1) heating 20ml of deionized water to 90°C to maintain a constant temperature, then weighing 1.6g of polyvinyl alcohol and adding in three times In water and constantly stirring, until polyvinyl alcohol dissolves completely, obtain the polyvinyl alcohol solution that mass fraction is 8%; (2) accurately weigh 10g hydroxyapatite powder and 0.4g nano carbon powder, carbon powder is mixed with hydroxyl Mix the apatite powder evenly, then add 2ml of polyvinyl alcohol solution dropwise to the mixed powder, stir while dripping, and then perform ball milling to make it fully mixed to obtain a wet powder; (3) Put the wet powder into the mold three times Carry out calendering in the middle into sheets, the pressure is 5MPa, and the pressure is kept for 5min to obtain a preliminary green body, then put the green body into a rubber glove to draw a vacuum...

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Abstract

The invention belongs to the technical field of biomaterials science and particularly relates to a meso-porous hydroxyapatite ceramic percutaneous implanting pathway device and a preparation method thereof. By regulating a dosage of an adhesive, selecting a pore former, regulating a proportion of the pore former and determining a sintering schedule, prepared meso-porous hydroxyapatite ceramic alsohas excellent mechanical performance in a state of enough pores; the meso-porous hydroxyapatite ceramic has good biocompatibility when implanted into a body as a percutaneous implanting pathway device, can be embedded into the body for a long time and has a wide application prospect; by utilizing the meso-porous hydroxyapatite ceramic percutaneous implanting pathway device provided by the invention, an entirely new medication and treatment method is hopefully facilitated, and by utilizing ceramic pore diffusion to perform active continuous or discontinuous medication, the toxic and side effects of a drug can be reduced, and targeted drug delivery is realized.

Description

technical field [0001] The invention belongs to the field of biomaterial science and technology, and in particular relates to a mesoporous hydroxyapatite ceramic percutaneously implanted access device and a preparation method thereof. Background technique [0002] A transdermal device refers to an implant that is partly implanted subcutaneously through the skin and maintains part of the skin wound or protrudes from the skin. It can be used as a device for transmitting material information inside and outside the body (can be combined with biosensors), and is an important part of biomaterial science and engineering. an important field of research. The percutaneous device is expected to be used for assisting vocalization, dialysis treatment, catheterization of benign prostatic hyperplasia, and measurement of biological information in vivo. Such as percutaneous catheters for the exchange of nutrients or drugs, skin windows for observation and collection of various information i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447A61L31/02A61L31/14C04B38/00C04B35/64B28B3/00
CPCA61L31/026A61L31/14A61L31/146B28B3/00B28B3/003C04B35/447C04B35/64C04B38/0054C04B2235/3217C04B2235/422C04B2235/661C04B2235/96
Inventor 王欣宇李明朝周青向书杰
Owner WUHAN UNIV OF TECH
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