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A method for laser synthesis of magnetic graphene-peg-γ-Fe2O3 composites

A magnetic graphene, laser synthesis technology, applied in pharmaceutical formulations, preparations for in vivo experiments, MRI/MRI contrast agents, etc., can solve the problems of complex experimental steps, low yield, cytotoxicity, etc., and achieve simple The effect of the synthesis process

Active Publication Date: 2019-04-09
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The object of the invention is to provide a kind of laser synthetic magnetic graphene-PEG-γ-Fe 2 o 3 The compound method is to solve the technical problems of complex experimental steps, low yield, and certain cytotoxicity when the product is used for tumor treatment in the existing chemical synthesis of magnetic graphene compound

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  • A method for laser synthesis of magnetic graphene-peg-γ-Fe2O3 composites
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  • A method for laser synthesis of magnetic graphene-peg-γ-Fe2O3 composites

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Embodiment 1

[0019] This embodiment provides a method for synthesizing graphene-PEG-γ-Fe by nanosecond laser ablation in liquid phase 2 o 3 A compound method comprising the steps of:

[0020] (1) Using a block iron target with a purity of 99.9% as a raw material, polish the surface of the target with sandpaper, and ultrasonically clean it with dilute hydrochloric acid to remove its oxide layer; then ultrasonically clean the surface of the iron target twice with deionized water to remove Residual dilute hydrochloric acid, then dry the iron target for use;

[0021] (2) Put the dry iron target in a 50 ml beaker, add 20 ml of graphene-PEG solution with a concentration of 0.2 mg / mL, so that the liquid level above the iron target is 0.5-1.5 cm;

[0022] (3) Start the nanosecond laser, and use focused light with a wavelength of 1064 nanometers to ablate the iron target in step (2), wherein the laser energy, frequency, and action time are 180-250 mJ, 10-15 Hz, 30- 40 minutes; the target is move...

Embodiment 2

[0025] This embodiment provides a method for synthesizing graphene-PEG-γ-Fe by nanosecond laser ablation in liquid phase 2 o 3 A compound method comprising the steps of:

[0026] (1) Using a block iron target with a purity of 99.9% as a raw material, polish the surface of the target with sandpaper, and ultrasonically clean it with dilute hydrochloric acid to remove its oxide layer; then ultrasonically clean the surface of the iron target twice with deionized water to remove Residual dilute hydrochloric acid, then dry the iron target for use;

[0027] (2) Put the dry iron target in a 50 ml beaker, add 20 ml of graphene-PEG solution with a concentration of 0.5 mg / mL, so that the liquid level above the iron target is 0.5-1.5 cm;

[0028] (3) Start the nanosecond laser, and use focused light with a wavelength of 1064 nanometers to ablate the iron target in (2), where the laser energy, frequency, and action time are 180-250 mJ, 10-15 Hz, 30-40 Minutes; the target was moved every 2...

Embodiment 3

[0031] This embodiment provides a method for synthesizing graphene-PEG-γ-Fe by nanosecond laser ablation in liquid phase 2 o 3 A compound method comprising the steps of:

[0032] (1) Using a block iron target with a purity of 99.9% as a raw material, polish the surface of the target with sandpaper, and ultrasonically clean it with dilute hydrochloric acid to remove its oxide layer; then ultrasonically clean the surface of the iron target twice with deionized water to remove Residual dilute hydrochloric acid, then dry the iron target for use;

[0033] (2) Put the dry iron target in a 50 ml beaker, add 20 ml of graphene-PEG solution with a concentration of 0.8 mg / mL, so that the liquid level above the iron target is 0.5-1.5 cm;

[0034] (3) Start the nanosecond laser, and use focused light with a wavelength of 1064 nanometers to ablate the iron target in (2), where the laser energy, frequency, and action time are 180-250 mJ, 10-15 Hz, 30-40 Minutes; the target was moved every...

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Abstract

The invention discloses a method for laser synthesis of a magnetic graphene -PEG-gamma-Fe2O3 compound. The method comprises the following steps: (1) by taking a blocky iron target as a raw material, polishing the surface of the target, performing ultrasonic washing with diluted hydrochloric acid to remove an oxidation layer of the target, further performing ultrasonic washing with deionized waterto remove residual diluted hydrochloric acid, and drying for later use; (2) putting the dried target into a flask, and adding a graphene-PEG (Polyethylene Glycol) solution; (3) powering on a nanosecond laser emitter, and ablating the iron target with focused light of a wavelength of 1064nm for 30-40 minutes; (4) after the laser action, taking out the solution, and performing centrifugal drying onthe solution, thereby obtaining a compound powder product. By adopting the method, the magnetic graphene -PEG-gamma-Fe2O3 compound with in-situ combination can be prepared rapidly at one step, in theprocess of laser synthesis of the compound, only the iron target, the deionized water and the graphene-PEG solution with cell compatibility are used, and no other organic reagent or complexing agent is used, so that the product is free of other toxic impurity, and the synthesis process is green and simple.

Description

technical field [0001] The invention relates to a method for synthesizing nanomaterials, in particular to a method for synthesizing a magnetic graphene-based compound. Background technique [0002] The new carbon nanomaterial graphene (graphene) and its derivatives, because of their good biocompatibility, large specific surface area, and easy surface modification, have been used in tumor drug therapy, photothermal therapy, gene therapy, etc. in recent years. It has a wide range of applications, see Bai RG, Ninan N, et al. Progress in Materials Science, 2018,1, 24-69. In the graphene-based composites with magnetism, the two-dimensional structure of graphene provides a larger specific surface area, which can better load drugs; while the magnetic nanoparticles composited with graphene often have high penetration ability and high The advantages of the resolution rate can enhance the ability to identify and diagnose tumors, so that high-resolution dynamic measurement of importan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/12A61K49/08
CPCA61K49/08A61K49/126
Inventor 陈学敏刘瑞红李发堂
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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