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Functionalized Fe3O4 nano-particle and preparation method and application thereof

A nanoparticle and functionalized technology, applied in the field of functionalized Fe3O4 nanoparticles and their preparation, can solve problems such as central nervous system disorders, toxicity, animal poisoning, etc., achieve good enrichment and purification ability, shorten pretreatment time, improve The effect of efficiency

Inactive Publication Date: 2013-04-17
INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although organic arsenic is of great significance to the development of animal husbandry, organic arsenic also has certain toxicity. Excessive addition can cause disorders of the central nervous system of animals and increase the incidence of encephalopathy and optic atrophy
Moreover, organic arsenic may be degraded into other arsenic compounds during feed processing, storage and transportation, which will be toxic to animals and threaten human health.

Method used

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  • Functionalized Fe3O4 nano-particle and preparation method and application thereof
  • Functionalized Fe3O4 nano-particle and preparation method and application thereof
  • Functionalized Fe3O4 nano-particle and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, functionalized Fe 3 o 4 Synthesis of Nanoparticles

[0022] (1) Synthesis of carboxymethyl-α-cyclodextrin

[0023] Dissolve α-cyclodextrin (3.47g, 3.55mol) and sodium hydroxide (3.62g, 90.2mmol) in 20mL of water, heat at 90°C for 5min, add sodium chloroacetate (8.73g, 74.6mmol), and continue stirring Heating for 3h. After the reaction is complete, cool to room temperature. After adjusting the pH value to 6-7 with hydrochloric acid, pour it into methanol solution to produce a white precipitate, filter it, wash it with methanol and water, dry it and place it in a desiccator for later use.

[0024] (2) Magnetic Fe 3 o 4 Synthesis of particles

[0025] Prepare 0.75moL / L 250mL sodium hydroxide solution, and ultrasonically deoxygenate for 20min. Prepare 250mL of 12mol / L hydrochloric acid solution, and ultrasonically deoxygenate for 20min.

[0026] 2g FeCl 2 4H 2 O and 5.2 g FeCl 3 ·6H 2 O was added to a 500mL Erlenmeyer flask, 0.85mL of 12mol / L hydr...

Embodiment 2

[0031] Embodiment 2, functionalized Fe 3 o 4 Performance testing of nanoparticles

[0032] (1) Influence of adsorption solvent

[0033]The adsorption effect of functionalized magnetic nanoparticles on five kinds of benzene arsenic acid (aminobenzene arsenic acid, p-hydroxyphenyl arsenic acid, p-nitrophenyl arsenic acid, p-amidophenyl arsenic acid and Roxarsarsenic acid) was investigated. , acetone and toluene, the functionalized magnetic nanoparticles have a good adsorption effect on the five kinds of benzene arsenic acid, and the adsorption efficiency reaches 100%. The specific adsorption results are as follows figure 2 shown.

[0034] (2) Enrichment factor

[0035] Investigation of functionalized magnetic nanoparticles CM-α-CD-Fe in ethanol solutions of 0.1 ng / mL benzene arsenic acid 3 o 4 The enrichment factor, the results show that CM-α-CD-Fe 3 o 4 The enrichment factors for five phenylarsenic acids including p-APAA, AAPAA, ROX, p-HPAA and p-NPAA were 414, 426, 58...

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Abstract

The invention discloses a functionalized Fe3O4 nano-particle and a preparation method and application of the functionalized Fe3O4 nano-particle. The preparation method comprises the following steps of: (1) under inert atmosphere, adding FeCl2 and FeCl3 into the mixed solution of sodium hydroxide aqueous solution and hydrochloric acid solution for reaction to obtain Fe3O4 nano-particles; and (2) reacting carboxymethyl-alpha-cyclodextrin with Fe3O4 nano-particles in PBS (Phosphate Buffer Solution), thereby obtaining the functionalized Fe3O4 nano-particles. The Fe3O4 nano-particle modified by alpha-cyclodextrin provided by the invention can simultaneously have good enrichment and purification abilities to trace phenylarsonic acid in complex samples; and meanwhile, the Fe3O4 nano-particle is superparamagnetic, so that centrifugation is not needed in sample processing, the pretreatment procedures of the sample are greatly simplified, the pretreatment time is shortened, and the pretreatment efficiency of the sample is improved.

Description

technical field [0001] The invention relates to a functionalized Fe 3 o 4 Nanoparticles and their preparation methods and applications. Background technique [0002] Organic arsenic is used as a feed additive, including roxarsarsenic acid, arsanic acid, p-hydroxyphenylarsenic acid, p-nitrophenylarsenic acid, amidophenylarsenic acid, etc. (see figure 1 ). Among them, 3-nitro-4-hydroxy-benzene arsenic acid (Roxarsone, ROX) and p-aminobenzene arsenic acid (p-ArsanilicAcid, p-ASA). These two organic arsenic feed additives are widely used in countries all over the world. The U.S. Food and Drug Administration (FDA) first allowed Roxarsarsenic to be used in chicken feed in 1964, and was officially approved as a growth promoter for pigs and chickens in 1983. The Ministry of Agriculture of my country approved the use of organic arsenic preparations in 1996, and then my country gradually began mass production and widely used in livestock and poultry breeding. [0003] Although o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/24B01J20/30B01D15/00G01N1/40
Inventor 苏晓鸥王培龙朱若华贾静张维李阳王瑞国
Owner INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
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