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Degradable corrosion-resistant magnesium alloy for vascular stents, and preparation method of degradable corrosion-resistant magnesium alloy

A vascular stent and magnesium alloy technology, applied in the field of medical alloys, can solve problems such as vascular wall irritation, vascular stenosis, increased probability of vascular intimal hyperplasia, etc., to avoid damage to human health, excellent mechanical properties and corrosion resistance, important Effects of social and economic significance

Inactive Publication Date: 2018-07-13
温州市赢创新材料技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The non-degradable metal stent remains in the human body as a foreign body, which will stimulate the blood vessel wall, significantly increase the probability of intimal hyperplasia of the blood vessel, and easily cause restenosis of the blood vessel

Method used

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  • Degradable corrosion-resistant magnesium alloy for vascular stents, and preparation method of degradable corrosion-resistant magnesium alloy
  • Degradable corrosion-resistant magnesium alloy for vascular stents, and preparation method of degradable corrosion-resistant magnesium alloy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A degradable and corrosion-resistant magnesium alloy for a blood vessel stent is characterized in that: it is composed of the following elements by mass percentage: Zn 9.5, Gd 2.1, Nd 1.6, Ca 1.5, Y 1.2, Mn 0.7, Zr 0.5, Sn 0.5, Si 0.2 , carbon nanotubes 0.1, Zn / Y 7.92, Zn / Ca 6.33, and the rest are Mg and inevitable impurity elements.

[0041] The preparation method of the degradable corrosion-resistant magnesium alloy for the blood vessel stent is characterized in that:

[0042] (1) Selection of raw materials

[0043] Mg ingot with a purity of 99.99%, Zn ingot with a purity of 99.99%, Mg-Zn master alloy with Zn mass ratio of 52wt%, Mg-Nd master alloy with Nd mass ratio of 19-20wt%, Gd mass ratio of 25% Mg-Gd master alloy, Mg-Zr master alloy whose mass ratio of Y accounts for Mg-Y master alloy, and Mg-Zr master alloy whose mass ratio of Zr accounts for 25%, other required elements are in the form of master alloy or element, and carbon nanotubes are in accordance with th...

Embodiment 2

[0051] A degradable corrosion-resistant magnesium alloy for a blood vessel stent is characterized in that: it is composed of the following elements in mass percentage: Zn9.7, Gd2.2, Nd1.65, Ca1.6, Y1.2, Mn0.7, Zr0.5, Sn0.5, Si 0.2, carbon nanotubes 0.12, Zn / Y 8.08, Zn / Ca 6.06, and the rest are Mg and inevitable impurity elements.

[0052] The preparation method of the degradable corrosion-resistant magnesium alloy for the blood vessel stent is characterized in that:

[0053] (1) Selection of raw materials

[0054]Mg ingot with a purity of 99.99%, Zn ingot with a purity of 99.99%, Mg-Zn master alloy with Zn mass ratio of 52wt%, Mg-Nd master alloy with Nd mass ratio of 19-20wt%, Gd mass ratio of 25% Mg-Gd master alloy, Mg-Zr master alloy whose mass ratio of Y accounts for Mg-Y master alloy, and Mg-Zr master alloy whose mass ratio of Zr accounts for 25%, other required elements are in the form of master alloy or element, and carbon nanotubes are in accordance with the target mag...

Embodiment 3

[0062] A degradable and corrosion-resistant magnesium alloy for a blood vessel stent is characterized in that: it is composed of the following elements by mass percentage: Zn9.9, Gd2.4, Nd1.75, Ca2, Y1.3, Mn0.9, ​​Zr0.55, Sn0.7, Si 0.3, carbon nanotubes 0.18, Zn / Y7.62, Zn / Ca 4.95, and the rest are Mg and inevitable impurity elements.

[0063] The preparation method of the degradable corrosion-resistant magnesium alloy for the blood vessel stent is characterized in that:

[0064] (1) Selection of raw materials

[0065] Mg ingot with a purity of 99.99%, Zn ingot with a purity of 99.99%, Mg-Zn master alloy with Zn mass ratio of 52wt%, Mg-Nd master alloy with Nd mass ratio of 19-20wt%, Gd mass ratio of 25% Mg-Gd master alloy, Mg-Zr master alloy whose mass ratio of Y accounts for Mg-Y master alloy, and Mg-Zr master alloy whose mass ratio of Zr accounts for 25%, other required elements are in the form of master alloy or element, and carbon nanotubes are in accordance with the targe...

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Abstract

The invention relates to degradable corrosion-resistant magnesium alloy for vascular stents. The degradable corrosion-resistant magnesium alloy is characterized by being prepared from the following elements: Zn, Gd, Nd, Ca, Y, Mn, Zr, Sn and Si as well as carbon nanotubes, Zn / Y, Zn / Ca and the balance of Mg and unavoidable impurity elements, wherein the unavoidable impurity elements are prepared from the following components by weight percent: 0.002-0.005% of Fe, 0.005-0.008% of Ni and less than or equal to 0.001% of Cu; the particle sizes of Mg3Nd precipitates in a metallographic structure are0.15-0.2mu m, the particle sizes of Mg3Y2Zn3 precipitates are 0.1-0.2mu m, and the particle sizes of Ca2Mg6Zn3 precipitates in the metallographic structure are 0.25-0.3mu m; the magnesium alloy has aparticle size of 40-50mu m, a tensile strength of 320-380 MPa, a yield strength of 200-250 MPa, an elongation of 20-35% and a Young's modulus of 40-50 GPa.

Description

technical field [0001] The invention belongs to the field of medical alloys, in particular to a degradable and corrosion-resistant magnesium alloy for vascular stents. Background technique [0002] In recent years, the incidence of cardiovascular disease has been increasing, and endovascular stent is one of the most effective methods for the treatment of cardiovascular disease. The materials currently used in the manufacture of vascular stents mainly include medical polymer materials and medical metal materials. The strength of medical polymer materials is low, and the degradation products are easy to cause problems such as inflammation and swelling. Metal materials such as stainless steel, cobalt-based alloys, and titanium-based alloys are biologically inert materials that will permanently exist inside the blood vessel after implantation. The long-term contact of the stent with the inner wall of the blood vessel causes damage to the vessel wall and intimal hyperplasia. T...

Claims

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Application Information

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IPC IPC(8): C22C23/04C22C26/00C22C1/10C22C1/06C22F1/06
CPCC22C1/06C22C1/1036C22C23/04C22C26/00C22F1/06C22C2026/002C22C1/1047
Inventor 周建武
Owner 温州市赢创新材料技术有限公司
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