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Mytilopsis surface modified magnesium alloy and preparation method and application thereof

A technology of surface modification and magnesium alloy, which is applied in pharmaceutical formula, metal material coating process, prosthesis, etc., can solve the problems of poor biocompatibility and poor corrosion resistance, achieve strong affinity and improve corrosion resistance , Improving the effect of corrosion resistance and cytocompatibility

Inactive Publication Date: 2018-07-13
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the characteristics of poor corrosion resistance, poor biocompatibility and no drug-loading ability of existing medical degradable magnesium alloy materials, the present invention provides a novel surface-modified magnesium alloy material and its preparation method and application to meet clinical needs. Requirements for Comprehensive Properties of Magnesium Alloys

Method used

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  • Mytilopsis surface modified magnesium alloy and preparation method and application thereof
  • Mytilopsis surface modified magnesium alloy and preparation method and application thereof
  • Mytilopsis surface modified magnesium alloy and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Use 600# and 1000# SiC sandpaper to remove the surface oxide layer of the AZ31 magnesium alloy sheet with a thickness of 2mm and a length and width of 10mm, and then use alcohol to clean it ultrasonically. Then carry out hydrothermal treatment, the hydrothermal solution is 50ml of 0.02M aluminum nitrate solution, and use sodium hydroxide or potassium hydroxide to adjust its pH value to 12.8, and finally react at 120°C for 12h. The resulting sample was labeled LDH.

[0044] figure 1 (b) is the scanning electron micrograph and optical picture of the surface morphology of the magnesium alloy obtained through the modification treatment in this embodiment. It can be seen from the figure that the surface of the LDH sample is a layer of dense nanosheets, and its color under natural light is light yellow. figure 2 (b) in this example shows the XRD pattern of the sample surface after the treatment of this embodiment. It can be seen from the figure that the structure of the LD...

Embodiment 2

[0046] Use 600# and 1000# SiC sandpaper to remove the surface oxide layer of the AZ31 magnesium alloy sheet with a thickness of 2mm and a length and width of 10mm, and then use alcohol to clean it ultrasonically. Afterwards, the magnesium alloy sheet was placed in 2 mg / mL dopamine hydrochloride solution, and its pH value was adjusted to 8.5 by 0.1 M sodium hydroxide, and reacted at 37° C. for 12 hours. The resulting sample was labeled PDA.

[0047] figure 1 (c) is the scanning electron micrograph and optical picture of the surface morphology of the magnesium alloy obtained through the modification treatment of this embodiment. It can be seen from the figure that due to the corrosion during the sample preparation process, a large number of cracks appeared on the surface of the PDA sample, and its color under natural light was dark yellow, indicating that polydopamine was generated on the surface. figure 2 (c) in the present embodiment provides the XRD pattern of the surface ...

Embodiment 3

[0049] The sample obtained from the treatment in Example 1 was placed in 2 mg / mL dopamine hydrochloride solution, and its pH value was adjusted to 8.5 with 0.1 M sodium hydroxide, and kept at 37° C. for 12 hours. The resulting sample is labeled L / P.

[0050] figure 1 (d) is the scanning electron micrograph and optical picture of the surface morphology of the magnesium alloy obtained through the modification treatment of this embodiment. It can be seen from the figure that the surface of the L / P sample is a layer of dense nanosheets, and its color under natural light is dark yellow. This shows that in the process of this embodiment, the original morphology of the sample surface will not be changed, but its optical color is brighter, indicating that polydopamine is generated on the surface of the material. figure 2 (d) among has provided the XRD pattern of sample surface after present embodiment treatment, can find out from figure, the structure of L / P sample surface is the m...

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Abstract

The invention provides a mytilopsis surface modified magnesium alloy and a preparation method and the application thereof. The surface modified magnesium alloy material comprises a magnesium alloy substrate, and a composite coating which is positioned on the surface of the magnesium alloy substrate, wherein the composite coating comprises an inner layer and an outer layer; the inner layer comprises a magnesium-alloy layer shaped double-metal hydroxide and a magnesium hydrate mixing phase; the outer layer comprises a polydopamine layer. According to the mytilopsis surface modified magnesium alloy, the magnesium-alloy layer shaped double-metal hydroxide, the magnesium hydrate mixing phase and the polydopamine layer in the composite coating are capable of synchronously and effectively improving the corrosion resistance of the magnesium alloy, so that cells can survive on a material surface; in addition, polydopamine is high in compatibility relative to the cells, so that the cells can beconveniently adhered to the material surface.

Description

technical field [0001] The invention relates to a surface modified magnesium alloy material and a surface modification method thereof, in particular to a method for surface modification of a magnesium alloy by hydrothermal treatment and dopamine self-polymerization reaction, belonging to the field of surface modification of metal materials. Background technique [0002] At present, most medical metal materials such as titanium alloys and nickel-titanium alloys are non-degradable materials, requiring a second operation to remove the implant, which brings heavy mental and economic pressure to patients. Therefore, the development of new biodegradable medical materials has very important social and research significance. Magnesium alloy is an ideal hard tissue replacement material and cardiovascular scaffold material because of its good mechanical properties, elastic modulus very close to that of bone tissue, and degradation products that can be excreted with the metabolism of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/30A61L27/34A61L27/50A61L27/58A61L31/02A61L31/08A61L31/10A61L31/14C23C18/12
CPCA61L27/047A61L27/306A61L27/34A61L27/50A61L27/58A61L31/022A61L31/088A61L31/10A61L31/14A61L31/148A61L2400/18A61L2420/02A61L2420/06A61L2420/08A61L2430/02C23C18/1204C08L79/02
Inventor 刘宣勇彭峰
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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