Soft capsules for treating sow postpartum endometritis and preparation method thereof

A technology for endometritis and soft capsules, applied in capsule delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of failure to achieve sustained release, reinjection of air or warm water , poor redispersibility and other problems, to achieve the effect of saving manpower and material resources, short melting time limit and high stability

Active Publication Date: 2018-07-10
湖北回盛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This product is an oily suspension packaged in a plastic perfusion device. Due to the prescription and process, the following problems are prone to occur: 1) The main drug is simply suspended in the oily matrix, and the research on the matrix is ​​not thorough enough, which may easily lead to the main drug from the oily matrix. The dissolution rate of the drug is low, and the pharmacological effect of the main drug cannot be fully exerted
2) Layering, poor redispersibility, easy to precipitate and agglomerate at low temperature
After long-term storage and stratification, it cannot reach the use state by re-mixing; low temperature is easy to break the emulsion, the drug precipitates, and agglomeration occurs
3) The biocompatibility is poor. After the drug is injected into the uterus, it is easy to settle and precipitate, and the sustained release effect cannot be achieved.
4) Plastic perfusion device packaging, long-term storage, the part of the piston in contact with the perfusion device is easily deformed, resulting in drug leakage
In addition, there are still some inconveniences when using this product, mainly in: 1) the sealed head of the plastic perfusion device needs to be cut off when using; 2) the oily suspension needs to be fully shaken before use; 3 ) After injecting the drug, it is necessary to inject air or warm water again to ensure that there is no drug residue in the catheter

Method used

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  • Soft capsules for treating sow postpartum endometritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method for soft capsules for treating postpartum endometritis in sows, the steps are as follows:

[0022] (1) Get 3700g polyethylene glycol 400 (92.5wt%), 80g propylene glycol (2wt%) and 120g glycerol (3wt%), stir and mix evenly, heat to 70 ℃, then add 100g chlorhexidine acetate (2.5wt%) %), stirred until completely dissolved, and filtered to obtain the water-soluble part containing chlorhexidine acetate. Weighed 700g of the volatile oil (70wt%) of Scutellaria chinensis, mixed with 200g of water (20wt%), and 100g of polyoxyethylene lauryl ether 58 (10wt%) to obtain the volatile oil part. At a temperature of 30°C and a stirring speed of 3000r / min, the volatile oil part was added to the solution of the water-soluble part to obtain a clear and transparent microemulsion.

[0023] (2) Take 100 parts of gelatin, 90 parts of purified water, 8 parts of PEG400 and 50 parts of glycerin. Put glycerin, purified water, and PEG400 into the plastic tank, stir and heat ...

Embodiment 2

[0026] A preparation method for soft capsules for treating postpartum endometritis in sows, the steps are as follows:

[0027] (1) Get 3100g polyethylene glycol 400 (77.5wt%), 200g propylene glycol (5wt%) and 200g glycerin (5wt%), stir and mix evenly, heat to 70 ℃, then add 500g chlorhexidine acetate (12.5wt%) %), stirred until completely dissolved, and filtered to obtain the water-soluble part containing chlorhexidine acetate. The volatile oil fraction was obtained by weighing 700 g of volatile oil (70 wt %) of Echinacea chinensis, 200 g of water (20 wt %), and 100 g of polyoxyethylene lauryl ether 58 (10 wt %) and mixing them uniformly. At a temperature of 30°C and a stirring speed of 3000r / min, the volatile oil part was added to the solution of the water-soluble part to obtain a clear and transparent microemulsion.

[0028] (2) Take 50 parts of gelatin, 50 parts of gum arabic, 90 parts of purified water, 5 parts of PEG400, 30 parts of glycerin, 10 parts of propylene glycol...

Embodiment 3

[0031] A preparation method for soft capsules for treating postpartum endometritis in sows, the steps are as follows:

[0032] (1) Get 2640g polyethylene glycol 400 (66wt%), 360g propylene glycol (9wt%), stir and mix evenly, be heated to 70 ℃, then add 1000g chlorhexidine acetate (25wt%), stir until dissolving completely, filter A water-soluble fraction containing chlorhexidine acetate was obtained. The volatile oil fraction was obtained by weighing 700 g of volatile oil (70 wt %) of Echinacea chinensis, 200 g of water (20 wt %), and 100 g of polyoxyethylene lauryl ether 58 (10 wt %) and mixing them uniformly. At a temperature of 30°C and a stirring speed of 3000r / min, the volatile oil part was added to the solution of the water-soluble part to obtain a clear and transparent microemulsion.

[0033] (2) Take 100 parts of gelatin, 100 parts of water, 3 parts of PEG400 and 40 parts of glycerin. Other operations were the same as in Preparation Example 1.

[0034] (3) Adopt full...

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Abstract

The invention provides soft capsules for treating sow postpartum endometritis and a preparation method thereof. The soft capsules are composed of a capsule material and medicine liquid, the capsule material comprises a sizing material, a plasticizer, a stabilizer and water according to a weight ratio of 100:40-50:3-8:90-100, the medicine liquid is composed of chlorhexidine acetate and volatile oilaccording to a proportion of 4:1(w/w), a chlorhexidine acetate portion is composed of 2.5-25wt% of chlorhexidine acetate and 75-97.5wt% of pharmaceutical ingredient, and the volatile oil portion is composed of 70wt% of mosla chinensis volatile oil and 30wt% of pharmaceutical ingredient. Chlorhexidine acetate and the mosla chinensis volatile oil are prepared into the soft capsules under synergism.The soft capsules are applied in the field of veterinary medicine, are for intrauterine administration to treat postpartum endometritis and are short in medicine melting time, quick in action, high in treatment efficiency, reliable in quality and convenient to use.

Description

technical field [0001] The invention relates to veterinary medicine for treating sow diseases, in particular to a new veterinary dosage form for treating sow endometritis—soft capsule and a preparation method thereof. Background technique [0002] Sow endometritis is one of the main diseases in pig reproductive disorders. It is mainly caused by pathogenic microorganisms invading the surface or deep layer of the uterine mucosa of sows. If pigs do not get timely and effective treatment, they will often turn into recessive or chronic infection, with reduced lactation, no milk or poor milk quality, and they are unwilling to breastfeed piglets, resulting in diarrhea and stunted growth of suckling piglets; Infertility, fewer litters, stillbirth, yellow and white diarrhea in suckling pigs and many other diseases, if it develops into intractable metritis, it will increase the elimination rate of production sows, and sows are prone to secondary infection of other diseases. Statistic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/48A61K47/10A61P15/00A61K31/155
CPCA61K9/4825A61K9/4866A61K31/155A61K36/53A61K2300/00
Inventor 张卫元张永丹李子彬朱秀高曾勇丁文格
Owner 湖北回盛生物科技有限公司
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