Liquid metal drug carrier as well as preparation method and application thereof

A liquid metal and drug technology, applied in the field of liquid metal drug system for the treatment of cervical cancer and breast cancer, to achieve the effect of strong operability, broad application prospects, and simple delivery and release process

Inactive Publication Date: 2018-07-06
YUNAN JINGCHUANG LIQUID METAL THERMAL CONTROL TECH RES & DEV CO LTD
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Problems solved by technology

In the aspect of applying liquid metal to fight cancer, Chinese patent application 201710347292.X proposes a liquid metal drug system and its preparation, delivery and release method, which uses electrical stimulation to precisely control the drug dose, accurately reach the drug release point, and realize drug release. delivery and release, but still need to control parameters such as current and voltage

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  • Liquid metal drug carrier as well as preparation method and application thereof

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Embodiment 1

[0051] (1) Preparation of liquid metal: according to the mass ratio (Ga 75 In 25 ) Weigh the metal gallium and indium, put the weighed gallium metal with a lower melting point into the beaker, use a magnetic stirrer, set the heating temperature to 60 °C, and add the weighed gallium into the beaker after the gallium is completely melted. For metal indium with a high melting point, set the rotation speed to 200r / min, stir at a constant speed until all the metals are completely melted, and then continue to stir for 5-10 minutes to obtain a homogeneous liquid metal.

[0052] (2) Preparation of nano-scale mixed suspension: according to the volume ratio of liquid metal and two kinds of high molecular polymer ligands as 1:150, that is to say, take liquid metal with a volume of 80 μL, containing 4 mg of thiolated (2 -Hydroxypropyl)-b-cyclodextrin (MUA-CD) and 0.5 mg thiolated hyaluronic acid (m-HA) in 12 ml ethanol. Add it into a centrifuge tube with a volume of 50ml, and then perfo...

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Abstract

The invention provides a liquid metal drug carrier as well as a preparation method and application thereof. The drug carrier is integrally a nanosphere with a core-shell structure; a core of the nanosphere is prepared from a nano-scale liquid metal particle; a shell of the nanosphere is prepared from two high-molecular polymer ligands. Such a drug carrier shows fusion in a weakly acid condition and subsequent degradation capacity; the anticancer treatment effect can be enhanced while an administration way is simplified. A drug system can be realized in preparation through simple ultrasonic treatment at room temperature; the loading, delivery and release processes of a drug are simple; the operability is high; further, the system has the obviously advantages of being degradable, nontoxic, harmless, green and environment-friendly, and the like, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of drug delivery, in particular to a liquid metal drug system for treating cervical cancer and breast cancer. Background technique [0002] Cancer is currently one of the main causes of harm to human health and death. Overcoming cancer has always been one of the research topics that the medical and scientific communities have devoted their energy and resources to. Chemotherapy, as one of the most commonly used means of cancer treatment, has a huge clinical demand, but it is difficult to obtain the desired effect. The main reason is that traditional chemotherapy has high toxicity and side effects, low bioavailability and lack of specific recognition ability. Drug delivery system (Drug delivery system, DDS) can overcome the above shortcomings of chemotherapy, so it has been the focus of research in the medical and academic circles. [0003] Using nanorobots that can flow between blood and particles to carry ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/40A61K47/36A61K31/704A61P35/00
Inventor 张海洋任文兵鄢顺才何霄盛磊刘静
Owner YUNAN JINGCHUANG LIQUID METAL THERMAL CONTROL TECH RES & DEV CO LTD
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