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Edrophonium chloride injection and preparation method thereof

A technology of efenonium chloride and injection, which is applied in the field of medicine, can solve problems such as weak electrical properties, and achieve the effects of high tensile strength, improved filtration efficiency, and increased specific surface area

Active Publication Date: 2018-06-15
GUANGDONG JIABO PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microporous filter membrane prepared by this method has weak electrical properties

Method used

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  • Edrophonium chloride injection and preparation method thereof
  • Edrophonium chloride injection and preparation method thereof
  • Edrophonium chloride injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1, the preparation method of nano-titanium dioxide-calcium alginate charged microporous membrane

[0029] Including the following steps:

[0030] Use a polysulfone filter membrane with a pore size of 0.22 μm as a carrier, immerse it in concentrated sulfuric acid for 1.5 hours, then rinse it with deionized water, immerse it in nano-titanium dioxide-calcium alginate sol for 15 minutes, rinse it with deionized water, and use it after drying. Calcium chloride aqueous solution with a mass fraction of 2.5% was used as a cross-linking agent, and the cross-linking time was 30 minutes. The charged microporous filter membrane of nano titanium dioxide-calcium alginate is obtained.

[0031] Among them, the nano-titanium dioxide-calcium alginate sol is prepared according to the following steps: take 100mL butyl titanate and dissolve it in 100mL absolute ethanol at room temperature to form a solution A; add another 50mL absolute ethanol to 300mL deionized water, and then ...

Embodiment 2

[0032] Embodiment 2, a kind of efenonium chloride injection

[0033] The efenonium chloride injection is composed of the following components: efenonium chloride 10g, anhydrous sodium sulfite 2.0g, water for injection added to 1000mL, and the pH is adjusted to 5.0 with a pH regulator.

[0034] The preparation method of this injection comprises the steps:

[0035] S1. Add water for injection of 60% of the prescription amount into the liquid preparation container, then add anhydrous sodium sulfite and stir until dissolved, add a pH regulator to adjust the pH value to 5.0, and obtain the mixed solution I;

[0036] S2. Add ephenonium chloride to the solution obtained in S1, stir until dissolved, filter, add water for injection to 1000ml, and stir evenly to obtain mixed solution II;

[0037]S3. The mixed liquid II is filtered through the nano-titanium dioxide-calcium alginate charged microporous membrane prepared in Example 1, and a pH regulator is added to adjust the pH value to ...

Embodiment 3

[0040] Embodiment 3, a kind of efenonium chloride injection

[0041] The efenonium chloride injection is composed of the following components: efenonium chloride 10g, anhydrous sodium sulfite 2g, water for injection added to 1000ml, and the pH is adjusted to 6.0 with a pH regulator.

[0042] The preparation method of this injection comprises the steps:

[0043] S1. Add 90% of the prescribed amount of water for injection into the liquid preparation container, then add anhydrous sodium sulfite and stir until dissolved, add a pH regulator to adjust the pH value to 6.0, and obtain the mixed solution I;

[0044] S2. Add ephenonium chloride to the solution obtained in S1, stir until dissolved, filter, add water for injection to 1000ml, and stir evenly to obtain mixed solution II;

[0045] S3. The mixed solution II is filtered through the nano-titanium dioxide-calcium alginate charged microporous membrane prepared in Example 1, and a pH regulator is added to adjust the pH value to 6...

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Abstract

The invention discloses edrophonium chloride injection and a preparation method thereof. The edrophonium chloride injection per 1000ml comprises the following components: 8-12g of edrophonium chloride, 1-4g of anhydrous sodium sulfite, and the balance of injection water; the pH of the injection is adjusted to be 4.0-7.0 through a pH conditioning agent, wherein the pH conditioning agent is a mixture consisting of citric acid and sodium citrate based on the weight ratio ranging from 1:2 to 1:5. The preparation method of the injection comprises the following steps: a) preparing an anhydrous sodium sulfite solution; adjusting the pH; adding edrophonium chloride; stirring until the solution is dissolved; b) filtering through a nano titanium dioxide-calcium alginate charged microporous membraneuntil the solution is clear; adjusting the pH; c) charging nitrogen and filling; sterilizing; detecting leakage; inspecting with light; packing. The edrophonium chloride injection prepared according to the formula and the method has the advantages that the step of filtering is eliminated, and is resistant to oxidization, resistant to bacteria, resistant to corrosion, free from degrading, and highin storage stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an efenonium chloride injection and a preparation method thereof. technical background [0002] Efenonium chloride, also known as Tengxilong, Aijufen, Ethyldimethylamine Chloride, Aifenol, is a quaternary ammonium reversible anticholinesterase drug, and its effect is the same as that of neostigmine. The cholinemimetic drug efenonium chloride is a classic short-acting cholinesterase inhibitor, which is clinically used as a diagnostic agent for myasthenia gravis and as an antagonist of skeletal muscle relaxants. The effect is rapid, the duration is short, and the side effects are small. Efenonium chloride is widely used at home and abroad, and its raw materials and injections have been included in the pharmacopoeias of the United States, Britain, Japan and other countries. In 1996, it was included in the "National Essential Drugs List" in my country. [0003] Ephenon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/14A61K47/02A61P21/04A61P21/00B01D67/00B01D61/14B01D69/02B01D71/82
CPCA61K9/0019A61K9/08A61K31/14A61K47/02B01D61/147B01D67/0006B01D69/02B01D71/82B01D2325/24
Inventor 曾少群彭创业李庆蔡文坚岳峰
Owner GUANGDONG JIABO PHARM CO LTD
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