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Graphite oxide nano silver terbinafine antifungal sustained-release thermosensitive hydrogel, and preparation method and application of hydrogel

A technology of terbinafine and nano-silver, which is applied in the direction of antifungal agents, pharmaceutical formulations, inorganic active ingredients, etc., can solve the problems of short duration of drug effect, easy recurrence, and not easy to persist for a long time, so as to enhance the bactericidal effect time, prolonged release and action time, enhanced antifungal effect

Active Publication Date: 2018-06-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, there are still many shortcomings in the existing treatment methods, mainly in: 1. Due to the common drug resistance of antifungal drugs, fungal infections are difficult to cure and easy to relapse; 2. The duration of drug effect is short; 3. Common dosage forms Inconvenient to use: the cream is inconvenient to apply; the spray is fluid and not easy to stay in the affected area for a long time

Method used

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  • Graphite oxide nano silver terbinafine antifungal sustained-release thermosensitive hydrogel, and preparation method and application of hydrogel
  • Graphite oxide nano silver terbinafine antifungal sustained-release thermosensitive hydrogel, and preparation method and application of hydrogel

Examples

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Embodiment 1

[0071] (1) Take 0.2g of micron-sized single-layer graphene oxide and disperse it in 100ml of deionized water, then place it in an ultrasonic pulverizer under ice bath conditions, and ultrasonically crack it for 1h to obtain a nanometer monolayer with a mass concentration of 0.2mg / ml Graphene oxide aqueous solution;

[0072] Add 105 mg of silver nitrate to 5 ml of deionized water, and then dropwise add ammonia water with a concentration of 3% until the precipitate disappears to obtain a silver ammonia solution;

[0073] Take 100ml of nano single-layer graphene oxide aqueous solution and the above-prepared silver ammonia solution and stir and mix at 50°C for 30min, then add 1g of glucose aqueous solution, and react at 90°C for 1h;

[0074] The reaction product system was placed in a centrifuge, and centrifuged for 20 minutes at a speed of 12000r / min, the supernatant was discarded, and the resulting precipitate was recovered, which was nano-silver oxide graphene oxide, denoted as...

Embodiment 2

[0080] (1) Take 0.4g micron-sized single-layer graphene oxide and disperse it in 100ml deionized water, then place it in an ultrasonic pulverizer under ice bath conditions, and ultrasonically crack it for 1h to obtain a nanometer monolayer with a mass concentration of 0.4mg / ml Graphene oxide aqueous solution;

[0081] Add 200 mg of silver nitrate to 5 ml of deionized water, and then dropwise add ammonia water with a concentration of 3% until the precipitate disappears to obtain a silver ammonia solution;

[0082] Take 100ml of nano single-layer graphene oxide aqueous solution and the above-prepared silver ammonia solution and stir and mix at 50°C for 30min, then add 3g of glucose aqueous solution, and react at 90°C for 1h;

[0083] The reaction product system was placed in a centrifuge, and centrifuged for 20 minutes at a speed of 12000r / min, the supernatant was discarded, and the resulting precipitate was recovered, which was nano-silver oxide graphene oxide, denoted as Ag-nG...

Embodiment 3

[0088] (1) Take 0.5g of micron-sized single-layer graphene oxide and disperse it in 100ml of deionized water, then place it in an ultrasonic pulverizer under ice bath conditions, and ultrasonically crack it for 1h to obtain a nanometer monolayer with a mass concentration of 0.5mg / ml Graphene oxide aqueous solution;

[0089] Add 50 mg of silver nitrate to 5 ml of deionized water, and then dropwise add ammonia water with a concentration of 3% until the precipitate disappears to obtain a silver ammonia solution;

[0090] Take 30ml of nano single-layer graphene oxide aqueous solution and the above-prepared silver ammonia solution and stir and mix at 50°C for 30min, then add 0.8g of glucose aqueous solution, and react at 90°C for 1h;

[0091] The reaction product system was placed in a centrifuge, and centrifuged for 20 minutes at a speed of 12000r / min, the supernatant was discarded, and the resulting precipitate was recovered, which was nano-silver oxide graphene oxide, denoted as...

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Abstract

The invention provides graphite oxide nano silver terbinafine antifungal sustained-release thermosensitive hydrogel, and a preparation method and an application of the hydrogel. The graphite oxide nano silver terbinafine antifungal sustained-release thermosensitive hydrogel takes graphite oxide as a drug sustained-release carrier, so that the drug release and action time is prolonged; at the sametime, loaded nano silver can continuously release silver ions to assist in improving an antifungal effect; due to a special sterilization mechanism of the silver ions, a drug resistance problem is notgenerated; the recurrence probability is low; similarly, poloxamer serves as an adjuvant; a drug can be in a liquid state at the room temperature; when the drug is applied to an affected site, the drug is changed into the hydrogel due to temperature rise; the administration is convenient; the contact time of the drug with the affected site can be prolonged; in addition, since the drug exists as anano ingredient, part of the drug can permeate into skin pores in a liquid form and is changed into the hydrogel due to an effect of the body temperature; and the fungicidal action time can be further prolonged.

Description

technical field [0001] The invention relates to the field of antifungal preparations, in particular to graphene oxide nano-silver terbinafine antifungal slow-release temperature-sensitive gel and its preparation method and application. Background technique [0002] Dermatophytes are fungi that can cause skin infections. These organisms reside in keratinous tissue and cause fungal infections, such as athlete's foot. Symptoms of fungal skin infections are characterized by lesions between the toes, which may extend to the feet The outer surface of the epidermis and the sole of the foot. The most common signs and symptoms of the infected area are redness, itching, and peeling, and the infection is contagious and may recur. [0003] At present, the conventional treatment method for skin infection is topical application of terbinafine, ketoconazole, miconazole, itraconazole and other antifungal creams, ointments, powders, solutions or sprays and other common dosage forms. Cover ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/10A61K31/137A61K47/04A61K33/38A61P17/00A61P31/10
CPCA61K9/06A61K31/137A61K33/38A61K47/02A61K47/10A61K2300/00
Inventor 滕士勇宋雪松李志文郭子龙李今硕杨文胜
Owner JILIN UNIV
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