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Magnetic calcium phosphate-based bone cement and preparation method thereof

A calcium phosphate and bone cement technology, applied in the field of medical orthopedic materials, can solve the problems of increasing growth factors, reducing the quality of life, increasing the mortality rate of bone tumors, etc. Effect

Inactive Publication Date: 2018-05-29
AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In secondary bone tumors, tumor cells release cytokines to activate osteoclasts, resulting in osteolysis, and the release of growth factors from the bone matrix increases, resulting in pathological fractures, hypercalcemia, pain, and spinal cord compression. disease, which greatly reduces the quality of life of patients and increases the mortality rate of bone tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Fe 3 o 4 Preparation: take 10mmolFe 2 (SO 4 ) 3 and 10 mmol FeSO 4 ·7H 2 O was dissolved in distilled water, then 40g of egg white liquid was added, stirred and reacted at 62°C for 30h, dried under reduced pressure, ground, and transferred to a muffle furnace at 500°C for 6h, then taken out and cooled with ice-water mixture, and distilled water and Wash each with absolute ethanol twice, and dry to obtain Fe 3 o 4 nanospheres.

[0026]Preparation of tetrapod zinc oxide: Take 5g of zinc powder and add it to a hydrogen peroxide solution with a concentration of 15wt%, stir for 30 minutes, then put it into an ultrasonic generator and sonicate for 1 hour, so that the zinc powder can fully contact and react with hydrogen peroxide, and let it stand for 15 hours. Filtrate, dry, and then add it to a tube furnace with a preheating temperature of 850°C for calcination for 5 minutes, and then perform plasma treatment for 15 minutes under the conditions of argon flow rate of ...

Embodiment 2

[0031] Fe 3 o 4 The preparation is with embodiment one.

[0032] Preparation of tetrapod-shaped zinc oxide: Take 5g of zinc powder and add it to a hydrogen peroxide solution with a concentration of 15wt% and stir for 30 minutes, then put it into an ultrasonic generator and ultrasonicate for 1 hour, so that the zinc powder can fully contact and react with hydrogen peroxide, and let it stand for 20 hours. Filtrate, dry, and then add it to a tube furnace with a preheating temperature of 950°C for calcination for 5 minutes, and then perform plasma treatment for 15 minutes under the conditions of argon flow rate of 120 sccm, pressure of 8 Pa, and power of 100 W to obtain tetrapod zinc oxide.

[0033] Preparation of β-tricalcium phosphate: Add calcium hydrogen phosphate dihydrate and 50 mmol calcium carbonate with a molar ratio of 75 mmol into a nylon ball mill jar, then add 10 mL of absolute ethanol, and then add zirconia grinding balls, in a multi-dimensional swinging nano ball m...

Embodiment 3

[0037] Fe 3 o 4 The preparation is with embodiment one.

[0038] Preparation of tetrapod zinc oxide: Take 5g of zinc powder and add it to a hydrogen peroxide solution with a concentration of 15wt%, stir for 30 minutes, then put it into an ultrasonic generator and sonicate for 1 hour, so that the zinc powder can fully contact and react with hydrogen peroxide, and let it stand for 15 hours. Filtrate, dry, and then put into a tube furnace with a preheating temperature of 900°C for calcination for 5 minutes, and then perform plasma treatment for 15 minutes under the conditions of argon flow rate of 120 sccm, pressure of 8 Pa, and power of 100 W to obtain tetrapod zinc oxide.

[0039] The preparation of β-tricalcium phosphate is the same as in Example two.

[0040] Preparation of magnetic composite powder: take 0.5gFe 3 o 4 Add 300mL of deionized water for ultrasonic dispersion for 30min, add 7mL of zinc acetate solution with a concentration of 0.1mol / L dropwise and stir for 30...

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Abstract

The invention relates to the technical field of a medical bone material, in particular to magnetic calcium phosphate-based bone cement and a preparation method thereof. The magnetic calcium phosphate-based bone cement is prepared from a solid phase mixed material and a liquid phase through mixing according to a solid-liquid ratio of 2.9 to 3.3g / mL; the solid phase mixed material is prepared from beta-tertiary calcium phosphate, calcium biphosphate and magnetic composite powder according to the mass ratio of (1.3 to 1.6):1:(0.2 to 0.3); the magnetic composite powder is a compound mainly prepared from ferroferric oxide, zinc oxide and carbon nanometer tubes. The liquid phase is citric acid solution added with glutin; the concentration of the citric acid solution is 0.2 to 0.4mol / L. The egg white pore-forming porous ferroferric oxide nanometer balls are used; the biocompatibility is improved; zinc oxide and carbon nanometer tubes coat the outside of the ferroferric oxide; on one hand, thefibrocyte multiplication, the bone growth and the bone mineralization can be promoted; on the other hand, a higher magnetic saturation value is realized; necessary conditions are provided for magnetic hyperthermia effect.

Description

technical field [0001] The invention relates to the technical field of medical orthopedic materials, in particular to a magnetic calcium phosphate-based bone cement and a preparation method thereof. Background technique [0002] Bone is the supporting structure of the human body and plays an important role in maintaining human health. At the same time, bone is also a common metastasis site of malignant tumors. In secondary bone tumors, tumor cells release cytokines to activate osteoclasts, resulting in osteolysis, and the release of growth factors from the bone matrix increases, resulting in pathological fractures, hypercalcemia, pain, and spinal cord compression. disease, which greatly reduces the quality of life of patients and increases the mortality of bone tumors. [0003] Magnetic induction thermotherapy mainly implants magnetic particles into the tumor area and exposes it to an alternating magnetic field, and the magnetic particles generate hysteresis loss to heat up...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/02A61L24/00A61K41/00A61P35/00
CPCA61K41/0052A61L24/001A61L24/0036A61L24/02A61L24/104
Inventor 徐海涛
Owner AFFILIATED YONGCHUAN HOSPITAL OF CHONGQING MEDICAL UNIV
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