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Chitosan/calcium alginate needleless electrospinning nanofiber membrane for medical dressings and preparation method thereof

A nanofiber, chitosan technology, applied in the chemical characteristics of fibers, textiles and papermaking, conjugated rayon, etc., can solve the problem of low use efficiency, achieve high processing efficiency, improve performance, and good hemostatic effect. Effect

Active Publication Date: 2019-01-25
DALIAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this method, the use of chitosan as a coagulation bath is not efficient, therefore, it is necessary to develop a new chitosan / calcium alginate needle-free nanofiber membrane and its preparation method

Method used

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  • Chitosan/calcium alginate needleless electrospinning nanofiber membrane for medical dressings and preparation method thereof
  • Chitosan/calcium alginate needleless electrospinning nanofiber membrane for medical dressings and preparation method thereof
  • Chitosan/calcium alginate needleless electrospinning nanofiber membrane for medical dressings and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037]Sodium alginate was directly dissolved in deionized water to make a 1wt% solution, and stirred at 80°C until the solution was transparent; chitosan was directly dissolved in 50wt% acetic acid solution in water, and made into a 1.5wt% solution at room temperature Stir at low temperature until the solution is transparent; dissolve PEO in deionized water to prepare an 8wt% solution, and stir at room temperature until the solution is transparent; mix the aqueous solution of sodium alginate and the aqueous solution of PEO at a volume ratio of 2:8, and stir for 10 hours to obtain Uniform sodium alginate / PEO solution; mix chitosan acid solution and PEO aqueous solution at a volume ratio of 5:5, and stir for 10 hours to obtain a uniform chitosan / PEO solution; mix chitosan / PEO solution with alginic acid Sodium / PEO solution was placed in needle-free electrospinning ( figure 1 As shown) the left and right sides of the solution box (at this time, the volume ratio of the three soluti...

Embodiment 2

[0040] Sodium alginate is directly dissolved in deionized water, prepared into a 1.5wt% solution, stirred at 80°C until the solution is transparent; chitosan is directly dissolved in 50wt% acetic acid solution, prepared into a 2wt% solution, in Stir at room temperature until the solution is transparent; dissolve PVP in deionized water to prepare a 10wt% solution, and stir at room temperature until the solution is transparent; mix sodium alginate aqueous solution and PVP aqueous solution at a volume ratio of 5:5, and stir for 10 hours. Obtain a uniform sodium alginate / PVP solution; mix chitosan acid solution and PVP aqueous solution at a volume ratio of 3:7, and stir for 10 hours to obtain a uniform chitosan / PVP solution; mix chitosan / PVP solution with seaweed NaCl / PVP solutions were placed in needle-free electrospinning ( figure 1 As shown) the left and right sides of the solution box (at this time, the volume ratio of the three solutions of sodium alginate aqueous solution, c...

Embodiment 3

[0042] Sodium alginate was directly dissolved in deionized water to make a 2wt% solution, and stirred at 80°C until the solution was transparent; chitosan was directly dissolved in 50wt% acetic acid solution to make a 1.5wt% solution at room temperature Stir under low pressure until the solution is transparent; dissolve PEO in deionized water to prepare an 8wt% solution, stir at room temperature until the solution is transparent; mix the aqueous solution of sodium alginate and the aqueous solution of PEO at a volume ratio of 1:9, and stir for 10 hours to obtain Uniform sodium alginate / PEO solution; mix chitosan acid solution and PEO aqueous solution at a volume ratio of 1:9, and stir for 10 hours to obtain a uniform chitosan / PEO solution; mix chitosan / PEO solution with alginic acid The sodium / PEO solution was placed on the left and right sides of the needle-free electrospinning solution box (at this time, the volume ratio of the three solutions of sodium alginate aqueous soluti...

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Abstract

The invention relates to a chitosan / calcium alginate needleless electrospinning nanofiber membrane for medical dressings and a preparation method thereof, and belongs to the field of natural biological polymer materials. According to the method, chitosan and a PEO (or PVP) solution and a sodium alginate solution and a PEO (or PVP) solution are placed on the two sides of an electrospinning solutionbox respectively, the two kinds of the solutions are gathered at spinnerets, polyelectrolyte self-crosslinking of the sodium alginate and the chitosan is allowed to be conducted in the volatilizationprocess of an electrospinning solvent to obtain a polyelectrolyte electrospinning nanofiber composite membrane composed of the self-crosslinking chitosan / sodium alginate, crosslinking is conducted onthe nano composite membrane by adopting a calcium chloride crosslinking method, so that calcium alginate is generated by the replacement of the sodium alginate and divalent calcium ions, and therefore the calcium alginate-chitosan composite nanofiber membrane is obtained. By means of the method, the mechanical performance and using performance of the material are improved through electrostatic force and calcium chloride crosslinking synergistic reaction, and the biological compatibility of the chitosan and the calcium alginate is fully achieved.

Description

technical field [0001] The invention belongs to the technical field of natural biopolymer materials, and relates to a calcium alginate / chitosan nanoscale medical dressing and a preparation method thereof. Background technique [0002] Due to its very high volume-to-surface ratio, nanofibers have high utilization value in the fields of tissue engineering, drug release, and medical dressings. Electrospinning technology is a simple and effective method to prepare nanofibers. The dressing absorbs the wound surface exudate and adheres to the wound surface at the same time, causing damage to the new tissue when it is removed, which brings great pain to the patient. The medical dressing made of nanofiber film is conducive to the evaporation of wound exudate, oxygen permeation, and the growth and regeneration of wound tissue, thereby accelerating wound healing. In recent years, nanofiber nonwoven fabrics It has become more and more widely used in medical dressings. [0003] Chito...

Claims

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Application Information

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IPC IPC(8): D04H1/4382D04H1/728D01F8/18
CPCD01F8/18D04H1/4382D04H1/728
Inventor 王迎雷红娜丁照轩
Owner DALIAN POLYTECHNIC UNIVERSITY
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