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Preparation method and application of boron-doped black zirconium dioxide nanoparticle

A technology of zirconium dioxide and nano-zirconium dioxide is applied in the field of preparation of boron-doped black zirconium dioxide nanoparticles, which can solve the problems of lack of tumor targeting, limited application of nano-materials, and high cost of nano-materials, and achieves good The effect of photothermal conversion efficiency, cheap and easily available raw materials, and good photostability

Active Publication Date: 2018-05-29
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional photothermal and photodynamic reagents are mainly gold nanomaterials and carbon nanomaterials, etc. These nanomaterials are expensive, complicated to prepare, poor in biocompatibility, and do not have tumor targeting, which greatly limits the above-mentioned Application of nanomaterials in the field of phototherapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A preparation method of boron-doped black zirconia nanoparticles, comprising the steps of:

[0025] (1) Weigh 1 g nanometer zirconia and 0.2 g sodium borohydride, grind them evenly for later use;

[0026] (2) Put uniformly ground nano zirconium dioxide and sodium borohydride into an alumina crucible, and burn in a tube furnace at 650°C for 2 hours;

[0027] (3) The fired solid was washed 3 times with distilled water and 3 times with ethanol, centrifuged at 5000 r / min, and dried in vacuum for 12 hours to obtain a black solid;

[0028] (4) The obtained black solid was ultrasonically dispersed in absolute ethanol, 200 µL of 3-aminopropyltriethoxysilane was added, 1 g of hyaluronic acid was added, and stirred for 24 hours;

[0029] (5) Dialyze the stirred solution for 3 days with a dialysis bag with a molecular weight cut-off of 10,000 Da;

[0030] (6) The solution after dialysis is freeze-dried to obtain the final product black zirconia nanoparticles.

Embodiment 2

[0032] A preparation method of boron-doped black zirconia nanoparticles, comprising the steps of:

[0033] (1) Weigh 1 g nanometer zirconia and 0.2 g sodium borohydride, grind them evenly for later use;

[0034] (2) Put uniformly ground nano zirconium dioxide and sodium borohydride into an alumina crucible, and burn in a tube furnace at 650°C for 4 hours;

[0035] (3) The fired solid was washed 3 times with distilled water and 3 times with ethanol, centrifuged at 5000 r / min, and dried in vacuum for 12 hours to obtain a black solid;

[0036] (4) The obtained black solid was ultrasonically dispersed in absolute ethanol, 200 µL of 3-aminopropyltriethoxysilane was added, 1 g of hyaluronic acid was added, and stirred for 24 hours;

[0037] (5) Dialyze the stirred solution for 3 days with a dialysis bag with a molecular weight cut-off of 10,000 Da;

[0038] (6) The solution after dialysis is freeze-dried to obtain the final product black zirconia nanoparticles.

Embodiment 3

[0040] (1) Weigh 1 g nanometer zirconia and 0.2 g sodium borohydride, grind them evenly for later use;

[0041] (2) Put uniformly ground nano zirconium dioxide and sodium borohydride into an alumina crucible, and burn in a tube furnace at 650°C for 6 hours;

[0042] (3) The fired solid was washed 3 times with distilled water and 3 times with ethanol, centrifuged at 5000 r / min, and dried in vacuum for 12 hours to obtain a black solid;

[0043] (4) The obtained black solid was ultrasonically dispersed in absolute ethanol, 200 µL of 3-aminopropyltriethoxysilane was added, 1 g of hyaluronic acid was added, and stirred for 24 hours;

[0044] (5) Dialyze the stirred solution for 3 days with a dialysis bag with a molecular weight cut-off of 10,000 Da;

[0045] (6) The solution after dialysis is freeze-dried to obtain the final product black zirconia nanoparticles.

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Abstract

The invention discloses a preparation method and application of a boron-doped black zirconium dioxide nanoparticle. The preparation method is characterized in that nanometer zirconium and sodium borohydride are taken as raw materials, 3-aminopropyltriethoxysilane and hyaluronic acid are adopted for modification to prepare the black zirconium dioxide nanoparticle, and the prepared black zirconium dioxide nanoparticle can enter a tumor cell to take the effect of photothermal and photodynamic therapy. The raw materials required for preparation are low in price and easily accessible. The preparation method is simple. The obtained product has favorable biocompatibility and water solubility, has strong absorption in ultraviolet, visible-light and near-infrared regions and favorable photothermalconversion efficiency, and can produce active oxygen under a light radiation condition so as to be used for photothermal and photodynamic therapy. The prepared boron-doped black zirconium dioxide nanoparticle has a wide application prospect in photothermal and photodynamic therapy.

Description

technical field [0001] The invention relates to the preparation and application of nanoparticles, in particular to a preparation method and application of boron-doped black zirconia nanoparticles. Background technique [0002] Zirconium dioxide is the main oxide of zirconium, which has been widely used in structural ceramics, sensors, solar cells, heat insulation materials, catalysts and other fields due to its excellent physical and chemical properties in the past few decades. However, its wide band gap determines that they can only absorb ultraviolet light, which accounts for less than 5% of natural light. Therefore, it is particularly important to improve the photocatalytic activity by doping to enhance the light absorption performance of zirconia. [0003] Photothermal therapy (Photothermal therapy, PTT) is a treatment method that converts light energy into heat energy through photothermal conversion reagents to ablate tumor tissue. Photodynamic therapy (PDT) is a new c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/02A61P35/00
CPCA61K9/5115A61K41/0052A61K41/0057A61K2300/00
Inventor 沈星灿丁兆扬蒋邦平郭晓路
Owner GUANGXI NORMAL UNIV
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