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High-strength natural high-molecular hydrogel film and preparation method thereof

A natural polymer and hydrogel technology, applied in medical science, prosthesis, surgery, etc., can solve problems such as mechanical strength gap, achieve good biocompatibility, excellent mechanical properties, and a wide range of controllable effects

Active Publication Date: 2018-05-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compared with biofilms (such as dura mater) in the human body, there is still a large gap in mechanical strength.

Method used

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  • High-strength natural high-molecular hydrogel film and preparation method thereof
  • High-strength natural high-molecular hydrogel film and preparation method thereof
  • High-strength natural high-molecular hydrogel film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Dissolve 0.04g kappa-type carrageenan in 1wt% dilute acetic acid solution, and make up to 100mL; dissolve 0.36g of chitosan whose deacetylation degree is 85% in 1wt% dilute acetic acid solution, and make up to 100mL 100mL; add 0.4mg / mL carrageenan solution and 3.6mg / mL chitosan solution dropwise to 50mL of 1wt% dilute acetic acid respectively, and stir vigorously at the same time to obtain a translucent uniform solution; After removing the air bubbles, the above mixed solution was transferred to a petri dish with a diameter of 150mm, and at the same time, the solvent was evaporated at a constant temperature at 70°C, and finally a dry film was obtained; the obtained dry film was soaked in a large amount of deionized water to reach an equilibrium state , the carrageenan / chitosan hydrogel film is obtained, wherein the mass ratio of carrageenan / chitosan is w r =1:9.

Embodiment 2

[0041] Dissolve 0.08g kappa-type carrageenan in 1wt% dilute acetic acid solution, and set the volume to 100mL, mix well and let stand; and set the volume to 100mL, mix well and let it stand; add dropwise the carrageenan solution of 0.8mg / mL and the chitosan solution of 3.2mg / mL respectively to the 1wt% dilute acetic acid filled with 50mL, and at the same time Stir vigorously to obtain a uniform translucent mixed solution; remove the air bubbles from the above mixed solution, transfer it to a petri dish with a diameter of 150mm, and evaporate the solvent at a constant temperature at 70°C, and finally obtain a dry film; the obtained The dry state film is soaked in a large amount of deionized water, when reaching equilibrium state, promptly obtains carrageenan / chitosan hydrogel film, wherein the mass ratio of carrageenan / chitosan is w r =2:8.

Embodiment 3

[0043] Dissolve 0.12g kappa-type carrageenan in 1wt% dilute acetic acid solution, and make up to 100mL; dissolve 0.28g of chitosan whose deacetylation degree is 85% in 1wt% dilute acetic acid solution, and make up to 100mL 100mL; add dropwise respectively the carrageenan solution of 1.2mg / mL and the chitosan solution of 2.8mg / mL to the container containing 50mL of 1wt% dilute acetic acid, and stir vigorously at the same time to obtain a whitish mixed solution; After removing the air bubbles, the above mixed solution was transferred to a petri dish with a diameter of 150mm, and at the same time, the solvent was evaporated at a constant temperature at 70°C, and finally a dry film was obtained; the obtained dry film was soaked in a large amount of deionized water to reach an equilibrium state The time to obtain the carrageenan / chitosan hydrogel film, wherein the mass ratio of carrageenan / chitosan is w r =3:7, the SEM picture is as follows figure 1 As shown, it can be seen from t...

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Abstract

The invention discloses a high-strength natural high-molecular hydrogel film which is prepared from carrageenan and chitosan through ionic bond bonding and hydrogen bond bonding; maximal breaking stress of the hydrogel film is not smaller than 6.7 MPa, and maximal elongation is not smaller than 120%. The invention further discloses a preparation method for the high-strength natural high-molecularhydrogel film, and the preparation method comprises the following steps: uniformly mixing a dilute acetic acid solution of carrageenan and chitosan at room temperature to obtain a white mixed solutionsystem; transferring the mixed solution into a flat-bottom container, and performing vacuum drying at a temperature of 70-90 DEG C, thereby obtaining a dry-state film; soaking the dry-state film intodeionized water to reach swelling balance, thereby obtaining a carrageenan / chitosan hydrogel film. The high-strength natural high-molecular hydrogel film prepared is transparent, is uniform, is goodin toughness, is strong in cell adhesion resistance, and can be applied to the medical field as a biological diaphragm material.

Description

technical field [0001] The invention belongs to the field of biopolymers, and in particular relates to a high-strength natural polymer hydrogel film and a preparation method thereof. Background technique [0002] There are a large number of biological films distributed around human organs and tissues, such as dura mater, periosteum and fascia, etc. In addition to their biological functions, these films usually have excellent mechanical properties. For example, the breaking strength of dura mater is 4-6MPa, and the breaking strain It is about 110%; in the field of biomaterials, it is an important and practical topic to develop alternative materials with mechanical properties matching the human body's own membranes to repair the damage of its own tissues. [0003] At present, the substitute materials of dura mater in surgical operation are mainly bovine pericardium and autologous membrane. However, bovine pericardium is opaque, and chemical reagents will be used in the proces...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/50A61L27/52A61L31/04A61L31/14
CPCA61L27/26A61L27/50A61L27/52A61L31/041A61L31/14A61L31/145C08L5/00C08L5/08
Inventor 吴子良虞海超郑强
Owner ZHEJIANG UNIV
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