Biomimetic mineralization material in a polyanion modified fiber, preparation method and application

Abstract

The invention discloses a polyanion modified fiber endobiomimetically mineralized material, a preparation method and application, and particularly relates to a construction method for cross-linking ahigh-molecular-weight polyanion electrolyte on the surface of a collagen scaffold material to form modified collagen, the surface of which carries a functional functional-group, by utilizing a high-molecular-weight polyelectrolyte with an anionic property, such as polyaspartic acid, polyacrylic acid, polyglutamic acid and the like, to simulate the function that non-endocollagen of an organism induces biomineralization and further inducing fiber endobiomimetic mineralization. The method comprises the following steps of treating different types of collagen scaffolds subjected to polyanion surface modification in a calcium phosphate mineralizing solution, so as to obtain a biomimetically mineralized collagen scaffold material with a fiber endomineralization characteristic. According to the preparation method, the fiber endobiomimetic mineralization is induced through the surface modification effect of the high-molecular-weight polyanion electrolyte on the collagen scaffold material, and anovel biomimetically mineralized collagen scaffold material which is similar to a natural bone tissue structure and has excellent mechanical performance and biocompatibility is constructed.

Description

technical field [0001] The invention belongs to the field of bionic mineralization materials and tissue engineering scaffold materials, and relates to a bionic mineralization material in a polyanion modified fiber, a preparation method and an application. Background technique [0002] Trauma, infection, tumor, and congenital diseases often cause different types of bone defects. About 2.2 million patients around the world need bone graft repair every year. It is currently the most widely used tissue transplant in clinical practice besides blood transfusion. Autologous bone and allogeneic bone are still the main bone defect repair materials at present. However, their limited sources, immune rejection and other defects have led to the continuous exploration of bone regeneration repair materials. An ideal regenerative repair material should have exactly the same structure and function as the defect tissue. Therefore, one of the current research hotspots in the field of bone rege...

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Problems solved by technology

However, these polyelectrolytes have strong anionic characteristics, and in the free state, they have certain toxicity; at the same time, when applied in the mineralized liquid, they are quickly diluted by body fluids, and it is difficult to ensure the effective concentration of the local polyelectrolytes, resulting in the inability to induce The role of intrafiber mineralization

Therefore, the traditional biomimetic mineralization model inevitably has defects such as poor biocompatibility, easy to cause biological stimulation, and difficulty in in vivo application.

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