Compound dexamethasone acetate cream and preparation method thereof
A technology of dexamethasone acetate and cream, applied in the directions of ointment delivery, pharmaceutical formulation, emulsion delivery, etc., can solve problems such as low absorption rate, influence stability of drug effect, waste of raw materials, etc., and achieve easy operation and cream properties. Stable, simple process effect
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[0049] According to one aspect of the present invention, a kind of preparation method of compound dexamethasone acetate cream, described method comprises the following steps:
[0050] (a) Fully dissolve the water-based auxiliary material in water to prepare the water phase, and keep it warm at 70-75°C for use; meanwhile, fully mix the oil-based auxiliary material at 70-75°C to prepare Prepare the oil phase and keep it warm at 70-75°C for later use;
[0051] (b), dimethyl sulfoxide is divided into two parts on average, the first part of dimethyl sulfoxide dissolves dexamethasone acetate and 2.6-di-tert-butyl p-cresol, and the second part of dimethyl sulfoxide dissolves camphor and menthol;
[0052] (c) Fully mix the water-based auxiliary materials and oil-based auxiliary materials prepared in step (a) at a temperature of 70-75°C, and add dexamethasone acetate and 2.6-di-tert-butyl Stir and homogenize the first part of dimethyl sulfoxide of p-cresol, then cool down to 40-45°C ...
Embodiment 1
[0063] A compound dexamethasone acetate cream, in parts by weight, said compound dexamethasone acetate cream is mainly made of the following components: 0.05 parts of dexamethasone acetate, 15 parts of water-based auxiliary materials, 10 parts of oil-based auxiliary materials 1 part, 1 part of dimethyl sulfoxide, 0.1 part of 2.6-di-tert-butyl-p-cresol, 1 part of camphor, 1 part of menthol and 155 parts of water;
[0064] The water-based auxiliary material comprises edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer; the mass ratio of the above-mentioned edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer is ,0.01:0.1:15:0.5:0.3;
[0065] The oil-based excipients include stearic acid, pinpinga, stearyl alcohol and cetyl alcohol; the mass ratio of the stearic acid, pinpinga, stearyl alcohol and cetyl alcohol is 5:1:1:1.
[0066] The preparation method of above-mentioned compound dexamethasone acetate cream comprises the fol...
Embodiment 2
[0071] A compound dexamethasone acetate cream, in parts by weight, said compound dexamethasone acetate cream is mainly made of the following components: 0.3 parts of dexamethasone acetate, 20 parts of water-based auxiliary materials, 18 parts of oil-based auxiliary materials 3 parts of dimethyl sulfoxide, 0.5 parts of 2.6-di-tert-butyl-p-cresol, 5 parts of camphor, 5 parts of menthol and 170 parts of water;
[0072] The water-based auxiliary material comprises edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer; the mass ratio of the above-mentioned edetate disodium, ethylparaben, propylene glycol, triethanolamine and carbomer is ,0.03:0.3:16:0.8:0.6;
[0073] The oil-based excipients include stearic acid, pinpinga, stearyl alcohol and cetyl alcohol; the mass ratio of the stearic acid, pinpinga, stearyl alcohol and cetyl alcohol is 7:3:3:3;
[0074] The preparation method of the compound dexamethasone acetate cream of this embodiment is the same as ...
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