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External application transdermal patch composition for treating gout

A technology for external application of drug patches and compositions, which is applied in the directions of drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of intolerance of patients, many adverse reactions, and large side effects, and achieves the promotion of drug absorption, no toxic side effects, and the use of simple method effect

Inactive Publication Date: 2018-04-20
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Small injuries, surgery, excessive drinking, excessive consumption of protein-rich foods, fatigue, emotional stress and various diseases can be induced. Western medicine often uses colchicine, indomethacin, and prednisone for patients with acute gouty arthritis. Etc., many adverse reactions, side effects, patients often can not tolerate, easy to relapse

Method used

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  • External application transdermal patch composition for treating gout
  • External application transdermal patch composition for treating gout
  • External application transdermal patch composition for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The raw materials in the external application plaster composition described in this embodiment are composed by weight: Atractylodes 10g, Phellodendron 10g, Barley 30g, Achyranthes bidentata 15g, Achyranthes bidentata 15g, Smilax 90g, Scutellaria 45g, Plantago 30g, Clematis 45g, Danshen 15g, Miltonia 30g, Lonicera 30g, Caulis 30g, Scorpion 30g, peach kernel 10g, safflower 10g, Polyporus 30g, Fangji 10g, Xijiancao 15g, Geranium 15g , Chuanshanlong 10g, Fried Dilong 15g, Polygala 10g, Chuanduan 20g, Sangjisheng 15g, Psoralen 30g, Anemarrhena 15g, Heishun tablets 45g, Duhuo 15g, Atractylodes macrocephala 15g, Wang Buliuxing 15g, Astragalus 30g, Guan Gui 6g, Asarum 9g.

[0015] The three flavors of Lonicerae vine, Caulis Caulis, and Teng Shi Teng described in this example are reasonable and strict in compatibility, can dredge the meridian and activate collaterals, dispel rheumatism and heat numbness, nourish blood and activate blood, clear away heat and detoxify, dispel wind...

Embodiment 2

[0024] In this example, the patch composition prepared in Example 1 was used, and it was found to be effective in gout patients in a center of integrated traditional Chinese and Western medicine, and gradually expanded to sub-healthy people for clinical treatment of boils. The invented drug was applied to acupuncture points, every three days One treatment, 7 times as a course of treatment, after a course of treatment, re-evaluate physical fitness, curative effect judging criteria, adopt comprehensive curative effect evaluation, refer to the "Guiding Principles for Clinical Research of New Chinese Medicines" issued by the Ministry of Health, the specific curative effect judging criteria are:

[0025] Healed: the total score of joint pain, tenderness, acute redness and swelling, and limited activity decreased by 100%; or the conversion score of physical fitness assessment was less than 30 points, and the conversion score of peace and quality was ≥80 points;

[0026] Significantly...

example 1

[0035] Case 1, Shan, male, 53 years old, gout, symptoms: the patient likes to drink alcohol, eats seafood, the first toe of the left and right feet is red, swollen, hot, painful, the ankle joints are red and swollen everywhere, the wrist joints of both hands are swollen, and the pain is abnormal, Refusal to press, Western medicine diagnosis of gout, similar medical history in the past, self-administration of colchicine, allopurine and other drugs, fat tongue, pale white, thick and greasy fur, floating pulse, large closing inch, body temperature 38 degrees, irritability, insomnia, Naco, sticky and greasy stools, yellow and red urine, sore waist and knees, obvious coldness in the waist and knee joints;

[0036] Dialectical: Spleen and Kidney Yang Deficiency Deficiency Yang Floating Phlegm Dampness Stasis Blocking Meridians

[0037] Therapeutic Principles: Invigorating the Spleen, Warming the Kidney, Resolving Phlegm, Dispelling Dampness, Activating Blood and Removing Blood Stasi...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and relates to an external application transdermal patch for treating gout by taking traditional Chinese herbal medicinesas raw materials. The raw materials include rhizoma atractylodis, platycladus orientalis, pearl barley, medicinal cyathula root, achyranthes root, rhizoma smilacis glabrae, yam rhizome, plantain herb,radix clematidis, salvia miltiorrhiza, caulis spatholobi, honeysuckle stem, kadsura pepper stem, Chinese starjasmine stem, peach kernel, safflower, grifola, fourstamen stephania root and the like. The preparation method comprises the following steps: processing the various selected traditional Chinese medicines, refining into medicine powder with the granularity of 80-100 meshes, mixing with a heating body to prepare the external application transdermal patch, and applying the patch to corresponding meridian points, wherein the heating body contains ferric chloride, iron powder and hydrochloric acid. When the external application patch is applied, the composition in the external application patch performs self-heating when meeting air, the contained volatile compounds continuously penetrate out of the patch, 'medicine spray' with temperature and humidity of 45-60 DEG C is formed in major acupuncture points and adjunct acupuncture points, and the medicine spray directly reaches the acupuncture points under the action of heating power and rapidly infiltrates into main and collateral channels so as to promote drug absorption. Moreover, the external application transdermal patch is reasonable and strict in compatibility of medicines, does not have any toxic or side effect, and has the effects of invigorating the spleen and strengthening body resistance, dispelling wind and eliminating dampness and activating meridians to stop pain, and the application environment is friendly.

Description

Technical field: [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to an externally applied medical patch for treating gout with Chinese herbal medicine as raw material, in particular to a drug combination externally applied medical patch for treating gout with Chinese herbal medicine as raw material and its preparation process and application method. Background technique: [0002] In recent years, with the improvement of people's living standards, the number of purines and other ingredients in the diet has increased, and the prevalence of gout patients has also increased year by year, especially in the southeast coast, where they like to eat high-purine foods such as seafood and beer. The prevalence of epidemiological surveys has exceeded 0.3%, and it is the second largest metabolic disease in humans after diabetes. Gout is more common in men, and the big toe is the most common affected area, with 50% to 70% of the initial onset...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/8994A61K9/70A61K47/02A61K47/04A61P19/06A61K35/62
CPCA61K9/0004A61K9/0009A61K9/7023A61K35/62A61K36/07A61K36/185A61K36/21A61K36/232A61K36/24A61K36/268A61K36/28A61K36/284A61K36/286A61K36/355A61K36/36A61K36/481A61K36/486A61K36/487A61K36/537A61K36/54A61K36/59A61K36/67A61K36/68A61K36/69A61K36/714A61K36/716A61K36/736A61K36/756A61K36/8945A61K36/896A61K36/8964A61K36/8994A61K36/90A61K47/02A61K2300/00
Inventor 倪同上黄彩娜胡瑞鹏王宏韬葛科立刘天蔚郭云良
Owner QINGDAO UNIV
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