Soft capsule with different disintegrating modes and preparation method thereof

Abstract

The invention relates to the field of medicine, and provides a soft capsule with different disintegrating modes. The soft capsule comprises a wall material and a content. The wall material is made ofsodium alginate which is formed through crosslinking of polyvalent metal ions in different degrees, the purpose that the soft capsule is disintegrated in different positions of human body alimentary canal can be achieved by controlling shifting of the polyvalent metal ions, adjusting the crosslinking degree of sodium alginate and adding aerogenic components into the wall material. The invention further provides a preparation method of the soft capsule with different disintegrating modes. The soft capsule provided by the invention can achieve oral disintegrating, gastric disintegrating, small intestinal disintegrating, colon disintegrating and external force smashing and disintegrating, can be suitable for the requirements for content disintegrating of different groups under different states and with different demands. In addition, a series of methods for preparing the soft capsule capable of achieving different disintegrating modes are simple and practicable, and suitable for large-scale production, and the cost is low.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a soft capsule with different disintegration modes and a preparation method thereof. Background technique [0002] Soft capsule is a commonly used dosage form in the pharmaceutical industry. It is welcomed by users because of its advantages of convenient use, convenient carrying, quantitative use, and high bioavailability. However, the rubber skin of soft capsules is generally composed of materials such as gelatin or starch. These materials are all hot-melt materials, that is to say, these materials control the process of rubber forming and digestive tract release according to the temperature. Therefore, this type of soft capsule is generally used for instant dissolution. The surface of the soft capsule is re-wrapped with enteric-coated materials or chemical cross-linking agents harmful to the human body are used. On the one hand, this type of soft capsule has a single functio...

AI Technical Summary

Problems solved by technology

[0004] The inventor once provided a method for making alginate soft capsules, see Chinese Patent: A Preparation Method for Alginate Soft Capsules (Application Number: CN200910027900.4, Publication Number: CN101564667A), and Chinese Patent: A Package Preparation method of alginate soft capsules with suspension of functional substances (application number: CN201110347884.4, publication number: CN102379859A), the alginate soft capsules produced by the above method are all enteric-coated soft capsules, and, due to The ionic strength in the channel shows great individual differences, and the same individual also shows great differences in different states. Therefore, the enteric properties of alginate soft capsules made by the above method also show great individual differences, even Individual users experience that the soft capsules are directly excreted from the body after taking them without any disintegration process