Antibacterial peptide KK26 and application thereof

Abstract

The invention discloses antibacterial peptide KK26 in the biologically technical field, and an amino acid sequence of the antibacterial peptide KK26 is Lys-Lys-Lys-Ile-Ala-Arg-Tyr-Leu-Asn-Tys-Gly-Ala-Ile-Val-Thr-Arg-Ile-Val-Leu-Pro-Trp-Val-Arg-Lys-Val-Arg. The antibacterial peptide is straight-chain polypeptide, contains 26 amino acid residues and has a molecular weight of 3141.4 Da and an isoelectric point of 12.13. The antibacterial peptide KK26 is low in hemolysis of red blood cells and wide in antibacterial spectrum and has an efficient antibacterial effect on gram-positive bacteria, gram-negative bacteria and some fungi. Therefore, the antibacterial peptide KK26 can be better applied to the preparation of an anti-infective bacterium or / and a fungal disease drug and an antibiotic replacement drug. Moreover, the antibacterial peptide KK26 disclosed by the invention can be applied to the anticorrosion of food, health products, cosmetics, feed and the like.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to an antibacterial peptide KK26 and its application. Background technique [0002] Antimicrobial peptides (AMPs) are a class of small-molecule active peptides that are encoded by genes and synthesized by ribosomes when organisms defend against the invasion of external pathogens. They are important components of the innate defense system in organisms. As a kind of biologically active small molecules, AMPs generally have anti-bacteria, fungi, viruses, protozoa and other activities. In addition, AMPs can also be used as drug delivery carriers, antitumor agents, immune modulators, and signaling molecules. [0003] As an important class of clinical drugs, antibiotics have saved countless lives since they were applied. However, in recent years, due to the increasingly serious problems of drug abuse, drug residues and bacterial resistance, more and more countries have begun to seek alternat...

AI Technical Summary

Problems solved by technology

Quite a few natural antimicrobial peptides have low antibacterial activity, poor stability, high toxicity, or cause hemolysis of eukaryotic cells; in addition, some antimicrobial peptides have poor inhibitory effect on drug-resistant bacteria and cannot meet the requirements of practical applications ; and artificial antimicrobial peptides obtained by modifying natural antimicrobial peptides or newly synthesizing them can improve some or even all of the above shortcomings to a large extent to meet different application requirements

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