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Perilla leaf oil and application thereof

A technology of perilla leaf oil and perilla aldehyde, applied in the field of medicine, can solve the problems of unreliable uniform standard of perilla leaf oil, complex component distribution, etc., and achieve the effects of low toxicity and good effect.

Inactive Publication Date: 2018-03-30
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In order to solve the above-mentioned problem that perilla leaf oil has a wide range of drug sources, complex distribution of components, and no unified standard for reliable, safe and effective perilla leaf oil, an object of the present invention is to provide a safe and effective medicinal product Perilla Leaf Oil

Method used

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  • Perilla leaf oil and application thereof
  • Perilla leaf oil and application thereof
  • Perilla leaf oil and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1: the preparation method of perilla leaf oil

[0049] 1) Weighing: Weigh 10kg perilla leaves and set aside;

[0050] 2) Distillation: Put the perilla leaves into the cleaned extraction tank, distill with water steam, keep the steam pressure at 0.1MPa, start timing from the drop of oil, distill for 3-5 hours, and the temperature is 100-120°C;

[0051] 3) Oil collection: after the steam is condensed, the distillate is collected, the dregs are discarded, and the distillate is allowed to stand for 20 minutes to obtain a water layer, a volatile oil layer, and an emulsified layer. The volatile oil layer is separated, and the water layer is discarded. Put it into a separatory funnel and continue to stand; the emulsified layer was left to stand for 12 hours, the water layer was discarded, and the volatile oil layers were combined to obtain perilla leaf oil (yield: 0.5%).

experiment example 1

[0052] Experimental Example 1: Content Detection

[0053] According to the method of embodiment 1, perilla leaf of Hunan Hanshou County, Hunan Taoyuan County, Hunan Dingcheng, Jiangsu Lianyungang, Chaozhou, Henan Nanyang, Guangxi Yulin, Anguo Shifo Town, Chongqing Fuling, Shandong Yantai and other places Carry out processing, extract and prepare the perilla leaf oil that obtains and detect, and specific detection method is:

[0054] 1. Preparation of the test solution: Take about 0.1g of perilla leaf oil, weigh it accurately, put it in a 10ml measuring bottle, add n-hexane to dilute to the mark, shake well, filter, and take the filtrate to get final product.

[0055] 2. Preparation of reference substance solution: Take an appropriate amount of perillaldehyde reference substance, weigh it accurately, add n-hexane to make a solution containing 4mg of perillaldehyde per 1ml, and obtain it.

[0056] 3. GC / MS analysis method:

[0057] Chromatographic conditions: chromatographic c...

experiment example 2

[0068] Experimental example 2: detection of moisture

[0069] 1. The detection method is Karl Fischer non-aqueous titration method, and the determination procedure is as follows:

[0070] (1) Calibration: Calibrate with 20 microliters of purified water by weight loss method, repeat the measurement three times, and only when the RSD of the calibration content of the three times is not greater than 1.0%, can the sample be measured.

[0071] (2) Sample measurement: take 0.1g sample for measurement, repeat the measurement three times for each sample, and when the content RSD of the three times is not more than 1.0%, record the average value of the three measurement values, which is the moisture content (%) of the sample.

[0072] 2. Test results: see Table 2-1, 2-2, 2-3

[0073] Table 2-1: Effect of secondary steam distillation time on total volatile oil yield

[0074]

[0075] Description: 1. Yield of volatile oil = weight of volatile oil / weight of perilla leaf for extractio...

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Abstract

The invention discloses a perilla leaf oil and an application thereof. The content of perillaldehyde in the perilla leaf oil is not less than 29%, the perilla leaf oil can be used in a compound traditional Chinese medicine as an active component to enhance the small intestine peristalsis promotion, fever relief, inflammation prevention and antibiosis effects, and the perilla leaf oil also can be used in Huoxiangzhengqi series varieties as a raw material, especially in Huoxiangzhengqi dripping pills, and also can be used as an active component to prepare a medicinal preparation together with apharmaceutically acceptable carrier.

Description

technical field [0001] The invention relates to the composition and application of perilla leaf oil, especially the application of perilla leaf oil with perillaldehyde as the main component, belonging to the field of medicine. Background technique [0002] Perilla leaves are the dry leaves (or twigs) of Perilla frutescens (L.) Britt., a plant of the Labiatae family. It is recorded in the previous editions of "Chinese Pharmacopoeia", and it is also included in the 15th and 16th editions of "Chinese Pharmacopoeia". Japanese Pharmacopoeia. In previous editions of the "Chinese Pharmacopoeia", for the determination of the content of perilla leaves, it is only stated that it is determined according to the determination method of volatile oil, kept at a slight boil for 2.5 hours, and the volatile oil content should not be less than 0.40%, and there is no active ingredient in perilla leaf oil. In the Japanese Pharmacopoeia, it is clear that the content of the active ingredient peri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/535A61K31/015A61K31/11A61K31/341A61P31/04A61P29/00A61P1/00A61K127/00
CPCA61K31/015A61K31/11A61K31/341A61K36/535A61K2236/331A61K2236/39A61K2300/00
Inventor 章顺楠朱永宏白晓林张继仲李婷魏鹏李艳梅马晓慧蔡金勇肖传学
Owner TIANJIN TASLY PHARMA CO LTD
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