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Preparation method and application of Ganoderma applanatum extract

A technology of extract and tree tongue, which is applied in the field of health care products and traditional Chinese medicine, can solve the problems of high risk, easy to cause gastrointestinal and cardiovascular diseases, and patients can not use it, and achieve low cost, significant effect, and greatly improved side effects Effect

Active Publication Date: 2018-02-09
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs used to reduce the concentration of uric acid in the human body mainly include: allopurinol, uricosuric drugs and diuretic drugs, including benzbromarone, uricase, PEG-modified uricase, etc. Metabolic organs have strong side effects so that patients with liver disease and kidney disease cannot use them, and these drugs are prone to gastrointestinal and cardiovascular diseases
This makes gout patients with high blood pressure, congestive heart failure, gastritis, ulcers, or renal insufficiency taking these drugs often at higher risk

Method used

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  • Preparation method and application of Ganoderma applanatum extract
  • Preparation method and application of Ganoderma applanatum extract
  • Preparation method and application of Ganoderma applanatum extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of Ethanol Extract from Tongue

[0050] Take 100 g of the fruiting body of Ligula ligata, crush it with a pulverizer, add it to an Erlenmeyer flask, and add 2L of ethanol, extract the mixture in a water bath at 65°C for 3 hours, and then filter it with a 400-mesh filter. The extraction experiment was repeated three times, and the obtained filtrates were combined, then concentrated to 25 mL by vacuum distillation, and freeze-dried to obtain 3.78 g of Ag.

Embodiment 2

[0052] Preparation of water extract of tongue tongue

[0053] In a water bath at 85°C, use 2L of water as a solvent to extract the residue of the tree tongue after alcohol extraction for 3 hours, and then filter under reduced pressure to separate the filter residue and filtrate. The extraction experiment was repeated three times. Dry to obtain 8.53 g of water extract (GAW), with a yield of 8.53%.

Embodiment 3

[0055] Determination of Triterpenes in the Extract of Tongue

[0056]Adopt HPLC method to measure total triterpene content, wherein (A) acetonitrile-(B) 0.03% phosphoric acid aqueous solution gradient elution, flow velocity is 1mL / min, detection wavelength is 252nm, column temperature is 29 ℃, records above-mentioned ethanol The content of triterpenes in the extract is 1097μg / g.

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Abstract

The invention discloses a preparation method of Ganoderma applanatum extract. According to the method, Ganoderma applanatum is extracted with ethanol, water or an ethanol and water mixed solvent takenas a solvent, the problem of organic solvent pollution or residues is solved, and the method is safe and environmentally friendly. The Ganoderma applanatum extract prepared with the method has a remarkable uric acid reducing action, has few side effects and can be used for preparing a drug for relieving gout symptoms, and a new direction is provided for improving the conventional phenomenon of more side effects of the gout treating drugs.

Description

technical field [0001] The invention relates to a preparation method of a tree tongue extract and a new application of the tree tongue extract in reducing uric acid, belonging to the fields of health care products and traditional Chinese medicines. Background technique [0002] Gout seriously plagues human life. Epidemiological studies in New Zealand, the United States and China have shown that gout is becoming more and more common, with an incidence rate of about 2% and increasing. Among them, the incidence rate is highest in people aged 65 and over, and the incidence rate of men is twice as high as that of women. Gout is the result of the development of hyperuricemia. It is because the concentration of uric acid in the body is higher than the dissolving capacity of the blood (>360μmol / L), resulting in the deposition of sodium urate crystals in soft tissues and joints. These deposited crystals cause repeated inflammation of soft tissues, joints and bone tissues severe p...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61P19/06
CPCA61K36/074A61K2236/33A61K2236/331A61K2236/39
Inventor 雍天乔谢意珍梁丹灵焦春伟
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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