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Antipyretics ibuprofen for children prepared by pressurized shock coating method for rapidly adjusting release velocity

A rapid adjustment and release speed technology, applied in the direction of antipyretics, drug combinations, inorganic non-active ingredients, etc., can solve problems such as no relevant research

Inactive Publication Date: 2018-01-30
锡山区东港全宝机械经营部
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no relevant research on the ropivacaine sustained-release drug delivery system using MBG as the carrier.

Method used

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  • Antipyretics ibuprofen for children prepared by pressurized shock coating method for rapidly adjusting release velocity

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0017] Step 1: Preparation of SiO2 colloidal crystal template

[0018] Preparation of monodisperse SiO2 microspheres: Monodisperse SiO2 microsphere suspensions were prepared by an alkaline hydrolysis process of ethyl orthosilicate (TEOS) using Stöber's method. Weigh 251.2 g of absolute ethanol, 118.25 g of deionized water and 34 g of NH3·H2O into a conical flask, mix well under magnetic stirring, add 27.7 g of TEOS, and continue magnetic stirring for 3 h to obtain a suspension of SiO2 particles liquid.

[0019] Preparation of SiO2 colloidal crystal template: firstly, the suspension of SiO2 particles prepared above is removed by rotary evaporation to remove excess solvent, then placed in a flat-bottomed container, and centrifuged to remove excess solvent to form a large disordered SiO2 colloid crystal template, and then sintered at a high temperature of 1000 ° C to obtain a SiO2 colloidal crystal template.

[0020] Step 2: Preparation of Inverse Colloidal Carbon Template

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Abstract

The invention relates to antipyretics ibuprofen for children prepared by a pressurized shock coating method for rapidly adjusting release velocity. The antipyretics ibuprofen for children prepared bythe pressurized shock coating method for rapidly adjusting the release velocity is characterized in that in a process of preparing a nanoparticle, MBGs and drug-loaded MBGs powder are dispersed evenlyand are tiled on a flat and smooth surface with sufficient surface strength, and then another flat and smooth round surface with sufficient hardness and enclosure circle around, and another flat andsmooth round surface with sufficient hardness are pressed on the MBGs and drug-loaded MBGs powder for prepressurization, two circular planar areas are equal, and an upper surface are embedded in an lower surface of the enclosure circle; then shaking is conducted, while shaking, the pressure is increased to a required pressure for pressurization, and then a PEG and PLA-PEG chloroform solution is dropwise dripped around the MBGs and drug-loaded MBGs powder for humidifying, and ventilation is maintained at room temperature until chloroform is completely volatilized.

Description

technical field [0001] The invention relates to children's antipyretic ibuprofen, which is produced by a pressurized vibration wrapping method and whose release speed is quickly adjusted. Background technique [0002] Ibuprofen is the only antipyretic drug for children jointly recommended by the World Health Organization and the US FDA, and is recognized as the first choice anti-inflammatory drug for children. Ibuprofen has anti-inflammatory, analgesic and antipyretic effects. It is slightly less effective than acetylsalicylic acid and phenylbutazone in the treatment of rheumatism and rheumatoid arthritis. [0003] Indicated for the treatment of mild to moderate migraine episodes, migraine prevention, chronic episodic hemigraine, exertion and menstrual headaches, rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylosis Inflammation and neuritis etc. [0004] Small-sized monodisperse drug-loaded mesoporous bioactive glass microspheres (MBGMs) / ethy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/10A61K47/34A61K31/192A61P29/00
Inventor 王全宝
Owner 锡山区东港全宝机械经营部
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